The recognition of membrane-bound PtdIns3P by PX domains.
Brisbane, Australia. In Proteins, 2014
In this work, molecular dynamic simulations have been used to explore the structure and dynamics of the p40(phox) -PX domain and the SNX17-PX domain and their interaction with membrane-bound PtdIns3P.
Sorting nexin 17 regulates ApoER2 recycling and reelin signaling.
Santiago, Chile. In Plos One, 2013
A previous yeast two-hybrid screen showed that ApoER2 is a binding partner of sorting nexin 17 (SNX17) - a cytosolic adaptor protein that regulates the trafficking of several membrane proteins in the endosomal pathway, including LRP1, P-selectin and integrins.
Cell adhesion: a FERM grasp of the tail sorts out integrins.
New Haven, United States. In Curr Biol, 2012
As well as modulating integrin activation, a conserved NPxY motif in integrin cytoplasmic tails that binds the FERM-domain-containing proteins kindlin and sorting nexin 17 plays pivotal roles in integrin recycling and degradation.