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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Sorting nexin 1

SNX1, sorting nexin 1
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This endosomal protein regulates the cell-surface expression of epidermal growth factor receptor. This protein also has a role in sorting protease-activated receptor-1 from early endosomes to lysosomes. This protein may form oligomeric complexes with family members. This gene results in three transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: SNX2, VPS35, V1a, CAN, Vps29
Papers on SNX1
Down-regulation of SNX1 predicts poor prognosis and contributes to drug resistance in colorectal cancer.
New
Huang et al., Wuxi, China. In Tumour Biol, Jan 2016
UNASSIGNED: As a potential tumor suppressor, the detailed clinical application value of sorting nexin 1 (SNX1) has not been elucidated in colorectal cancer (CRC).
Retromer: Structure, function, and roles in mammalian disease.
Review
New
Kim et al., Springfield, United States. In Eur J Cell Biol, Nov 2015
These five proteins (Vps5, Vps17, Vps26, Vps29, and Vps35 in yeast and SNX1/2, SNX5/6, Vps26, Vps29, and Vps35 in mammalian cells) act as a coat for vesicles budding off of the endosome, as well as perform cargo sorting at the endosome.
Phosphatidylinositol 3-Phosphate 5-Kinase, FAB1/PIKfyve Kinase Mediates Endosome Maturation to Establish Endosome-Cortical Microtubule Interaction in Arabidopsis.
New
Sato et al., Kyoto, Japan. In Plant Physiol, Nov 2015
We found that FAB1 predominantly localizes on the Sorting Nexin1 (SNX1)-residing late endosomes, and a loss of FAB1 function causes the release of late endosomal proteins, Ara7, and SNX1 from the endosome membrane, indicating that FAB1, or its product PtdIns(3,5)P2, mediates the maturation process of the late endosomes.
Overexpression of FAB1A-GFP recruits SNX2b on the endosome membrane in snx1-1 mutant in Arabidopsis.
New
Sato et al., Kyoto, Japan. In Plant Signal Behav, Nov 2015
Recently, we reported that FAB1 predominantly localizes on the SNX1-residing late endosomes and a loss-of FAB1 function causes the release of late endosomal effector proteins, ARA7/RABF2b and SORTING NEXIN 1 from the endosome membrane, indicating that FAB1 or its product PI(3,5)P2 mediates the maturation process of the late endosomes.
Glargine Promotes Human Colorectal Cancer Cell Proliferation via Upregulation of miR-95.
New
Wu et al., Nanning, China. In Horm Metab Res, Oct 2015
The expression of microRNA-95 (miR-95) and sorting nexin 1 (SNX1) protein was also determined by real-time PCR and Western blotting, respectively.
Receptor-mediated Endocytosis 8 Utilizes an N-terminal Phosphoinositide-binding Motif to Regulate Endosomal Clathrin Dynamics.
New
Vacratsis et al., Windsor, Canada. In J Biol Chem, Sep 2015
Interestingly, RME-8 endosomal association is also regulated by the PI(3)P-binding protein SNX1, a member of the retromer complex.
Gene expression in hepatocellular carcinoma: pilot study of potential transarterial chemoembolization response biomarkers.
New
Casadaban et al., Chicago, United States. In J Vasc Interv Radiol, May 2015
fold) pretreatment chemotherapy-sensitivity and mitosis (ATF4, BAX, CCNE1, KIF11, NFX1, PPP3CA, SNX1, TOP2A, and TOP2B) gene mRNA expression compared with tumors with PR, in addition to lower CXCL10 levels (0.48-fold), and had significantly (P < .05)
Abnormal Expression of miR-21 and miR-95 in Cancer Stem-Like Cells is Associated with Radioresistance of Lung Cancer.
New
Chen et al., Changsha, China. In Cancer Invest, May 2015
The anti-miRNAs significantly reduced miR-21 and miR-95 levels, increased PTEN, SNX1, and SGPP1 protein expression, but reduced Akt Ser(473) and Thr(308) phosphorylation.
Autoantibody Profiling of Glioma Serum Samples to Identify Biomarkers Using Human Proteome Arrays.
Srivastava et al., Mumbai, India. In Sci Rep, 2014
Proteins namely, SNX1, EYA1, PQBP1 and IGHG1 showed dysregulation across various grades.
SNX-BAR-mediated endosome tubulation is co-ordinated with endosome maturation.
GeneRIF
Cullen et al., Bristol, United Kingdom. In Traffic, 2012
SNX4, but not SNX1 and SNX8, is associated with the Rab11-recycling endosomes and that a high frequency of SNX4-mediated tubule formation is observed as endosomes undergo Rab4-to-Rab11 transition.
Mapping the interactions between a RUN domain from DENND5/Rab6IP1 and sorting nexin 1.
GeneRIF
Khan et al., Dublin, Ireland. In Plos One, 2011
A RUN Domain from DENND5/Rab6IP1 binds sorting Nexin 1 and is involved in the trafficking of vesicles at the level of Golgi.
A SNX3-dependent retromer pathway mediates retrograde transport of the Wnt sorting receptor Wntless and is required for Wnt secretion.
Impact
Korswagen et al., Utrecht, Netherlands. In Nat Cell Biol, 2011
Here, we report that Wls recycling is mediated through a retromer pathway that is independent of the retromer sorting nexins SNX1-SNX2 and SNX5-SNX6.
MicroRNA-95 promotes cell proliferation and targets sorting Nexin 1 in human colorectal carcinoma.
GeneRIF
Du et al., Shanghai, China. In Cancer Res, 2011
Results demonstrate that miR-95 increases proliferation by directly targeting SNX1, defining miR-95 as a new oncogenic miRNA in CRC.
A novel, retromer-independent role for sorting nexins 1 and 2 in RhoG-dependent membrane remodeling.
GeneRIF
Ngsee et al., Ottawa, Canada. In Traffic, 2010
SNX1 and SNX2 interact with Kalirin-7. Overexpression of SNX1 or SNX2 and Kalirin-7 partially redistributes both SNXs to the plasma membrane, and results in RhoG-dependent lamellipodia formation.
Regulation of P2Y1 receptor traffic by sorting Nexin 1 is retromer independent.
GeneRIF
Mundell et al., Bristol, United Kingdom. In Traffic, 2010
These data describe a novel function of SNX1 in the regulation of P2Y(1) receptor recycling and suggest that SNX1 plays multiple roles in endocytic trafficking of G-protein coupled receptors.
Retromer.
Review
Hurley et al., Bethesda, United States. In Curr Opin Cell Biol, 2008
The mammalian retromer complex comprises a sorting nexin dimer composed of a still undefined combination of SNX1, SNX2, SNX5 and SNX6, and a cargo-recognition trimer composed of Vps26, Vps29 and Vps35.
Retromer: multipurpose sorting and specialization in polarized transport.
Review
Verg├ęs, Valencia, Spain. In Int Rev Cell Mol Biol, 2007
A dimer of two sorting nexins-typically, SNX1 and/or SNX2-deforms the membrane and thus cooperates with retromer to ensure cargo sorting.
Functional architecture of the retromer cargo-recognition complex.
Impact
Hurley et al., Bethesda, United States. In Nature, 2007
Human retromer consists of two smaller complexes: the cargo recognition VPS26-VPS29-VPS35 heterotrimer and a membrane-targeting heterodimer or homodimer of SNX1 and/or SNX2 (ref.
AtSNX1 defines an endosome for auxin-carrier trafficking in Arabidopsis.
Impact
GeneRIF
Gaude et al., Lyon, France. In Nature, 2006
Arabidopsis thaliana SORTING NEXIN 1 (AtSNX1) is involved in the auxin pathway and that PIN2, but not PIN1 or AUX1, is transported through AtSNX1-containing endosomes [AtSNX1]
Enhanced degradation of EGF receptors by a sorting nexin, SNX1.
Impact
Gill et al., San Diego, United States. In Science, 1996
A protein, sorting nexin-1 (SNX1), was identified in a human cell line that bound to a region of the epidermal growth factor receptor (EGFR) containing the lysosomal targeting code.
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