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Small nuclear ribonucleoprotein polypeptide B

SNRPB2
The protein encoded by this gene associates with stem loop IV of U2 small nuclear ribonucleoprotein (U2 snRNP) in the presence of snRNP-A'. The encoded protein may play a role in pre-mRNA splicing. Autoantibodies from patients with systemic lupus erythematosus frequently recognize epitopes on the encoded protein. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
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Top mentioned proteins: TID1, Histone, HAD, NF-kappaB, Phosphogluconate Dehydrogenase
Papers on SNRPB2
A circulating antibody panel for pretransplant prediction of FSGS recurrence after kidney transplantation.
Sarwal et al., Paris, France. In Sci Transl Med, 2014
A panel of seven Abs (CD40, PTPRO, CGB5, FAS, P2RY11, SNRPB2, and APOL2) could predict posttransplant FSGS recurrence with 92% accuracy.
Drug screening for ALS using patient-specific induced pluripotent stem cells.
Inoue et al., Kyoto, Japan. In Sci Transl Med, 2012
The ALS motor neurons were characterized by increased mutant TDP-43 protein in a detergent-insoluble form bound to a spliceosomal factor SNRPB2.
Oxidized LDL immune complexes and oxidized LDL differentially affect the expression of genes involved with inflammation and survival in human U937 monocytic cells.
Lopes-Virella et al., Charleston, United States. In Atherosclerosis, 2009
oxLDL-IC uniquely affected the expression of genes involved with pro-survival (RAD54B, RUFY3, SNRPB2, and ZBTB24).
Molecular signature of MT1-MMP: transactivation of the downstream universal gene network in cancer.
Strongin et al., Los Angeles, United States. In Cancer Res, 2008
These genes included regulators of energy metabolism (NNT), trafficking and membrane fusion (SLCO2A1 and ANXA7), signaling and transcription (NR3C1, JAG1, PI3K delta, and CK2 alpha), chromatin rearrangement (SMARCA1), cell division (STK38/NDR1), apoptosis (DAPK1), and mRNA splicing (SNRPB2).
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