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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

PSO2 Pso2p

SNM1, PSO2
DNA interstrand cross-links prevent strand separation, thereby physically blocking transcription, replication, and segregation of DNA. DCLRE1A is one of several evolutionarily conserved genes involved in repair of interstrand cross-links (Dronkert et al., 2000 [PubMed 10848582]).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: Artemis, CAN, REV3, ACID, PSO
Papers on SNM1
Unravelling the role of SNM1 in the DNA repair system of Trypanosoma brucei.
New
Wilkinson et al., Auckland, New Zealand. In Mol Microbiol, May 2015
In yeast and humans, an enzyme that plays a key role in repairing such damage are the PSO2/SNM1 nucleases.
Sak1 kinase interacts with Pso2 nuclease in response to DNA damage induced by interstrand crosslink-inducing agents in Saccharomyces cerevisiae.
Henriques et al., Porto Alegre, Brazil. In J Photochem Photobiol B, 2014
By isolating putative binding partners through the two-hybrid system (THS) we further extended the characterization of the specific interstrand cross-link (ICL) repair gene PSO2 of Saccharomyces cerevisiae.
A decision support system to determine optimal ventilator settings.
Yarman et al., ─░stanbul, Turkey. In Bmc Med Inform Decis Mak, 2013
The diagnosed disease, core body temperature, pulse, arterial systolic pressure, diastolic blood pressure, PEEP, PSO2, pH, pCO2, bicarbonate data as well as the frequency, tidal volume, FiO2, and pressure support / volume support values suitable for use in the ventilator device have been recommended to the physicians with an accuracy of 98,44%.
Characterization of the human SNM1A and SNM1B/Apollo DNA repair exonucleases.
GeneRIF
McHugh et al., Oxford, United Kingdom. In J Biol Chem, 2012
differences in the substrate selectivities of SNM1A and SNM1B are likely to be relevant to their in vivo roles
Pso2 (SNM1) is a DNA structure-specific endonuclease.
Junop et al., Hamilton, Canada. In Nucleic Acids Res, 2012
Pso2 (SNM1A in mammals) belongs to a small group of proteins thought to function predominantly during interstrand crosslink (ICL) repair.
Artemis interacts with the Cul4A-DDB1DDB2 ubiquitin E3 ligase and regulates degradation of the CDK inhibitor p27.
Legerski et al., Houston, United States. In Cell Cycle, 2012
Artemis, a member of the SNM1 gene family, is a multifunctional phospho-protein that has been shown to have important roles in V(D)J recombination, DNA double strand break repair, and stress-induced cell-cycle checkpoint regulation.
Components of a Fanconi-like pathway control Pso2-independent DNA interstrand crosslink repair in yeast.
McHugh et al., Oxford, United Kingdom. In Plos Genet, 2011
Here, we reveal a key role for Mph1 in ICL repair when the Pso2 exonuclease is inactivated.
Human SNM1A and XPF-ERCC1 collaborate to initiate DNA interstrand cross-link repair.
GeneRIF
McHugh et al., Oxford, United Kingdom. In Genes Dev, 2011
collaboration between hSNM1A and XPF-ERCC1 is necessary to initiate interstrand cross-link repair in replicating human cells
RAD18-dependent recruitment of SNM1A to DNA repair complexes by a ubiquitin-binding zinc finger.
GeneRIF
D'Andrea et al., Boston, United States. In J Biol Chem, 2010
RAD18-dependent recruitment of SNM1A to DNA repair complexes by a ubiquitin-binding zinc finger
The multifunctional SNM1 gene family: not just nucleases.
Review
Legerski et al., Houston, United States. In Future Oncol, 2010
The archetypical member of the SNM1 gene family was discovered 30 years ago in the budding yeast Saccharomyces cerevisiae.
SNM1A acts downstream of ATM to promote the G1 cell cycle checkpoint.
GeneRIF
Legerski et al., Houston, United States. In Biochem Biophys Res Commun, 2009
These findings suggest that SNM1A acts with ATM to promote the G1 cell cycle checkpoint.
Mammalian SNM1 is required for genome stability.
GeneRIF
Moses et al., Portland, United States. In Mol Genet Metab, 2008
hSNM1 appears to represent a second pathway for genome stability
The eukaryotic Pso2/Snm1/Artemis proteins and their function as genomic and cellular caretakers.
Review
Henriques et al., Porto Alegre, Brazil. In Braz J Med Biol Res, 2005
The molecular function of Pso2p in DNA repair is unknown, but yeast and mammalian cell line mutants for PSO2 show the same cellular responses as strains with defects in NHEJ, e.g., sensitivity to ICLs and apoptosis.
Role of PSO genes in repair of DNA damage of Saccharomyces cerevisiae.
Review
Henriques et al., Porto Alegre, Brazil. In Mutat Res, 2003
Of the seven DNA repair genes involved in induced mutagenesis three PSO loci [PSO1/REV3, PSO8/RAD6, PSO9/MEC3] were allelic to already known repair genes, whereas three, PSO2/SNM1, PSO3/RNR4, and PSO4/PRP19 represent new genes involved in DNA repair and nucleic acid metabolism in S. cerevisiae.
The pso mutants of Saccharomyces cerevisiae comprise two groups: one deficient in DNA repair and another with altered mutagen metabolism.
Review
Henriques et al., Frankfurt am Main, Germany. In Mutat Res, 2001
Four of these PSO loci were found allelic to already known repair genes, whereas two, PSO2 and PSO4, represent new genes involved in DNA repair and in repair/pre-mRNA processing in S. cerevisiae.
A candidate prostate cancer susceptibility gene at chromosome 17p.
Impact
Cannon-Albright et al., Salt Lake City, United States. In Nat Genet, 2001
The gene product bears amino acid sequence similarity to two better understood protein families, namely the PSO2 (SNM1) DNA interstrand crosslink repair proteins and the 73-kD subunit of mRNA 3' end cleavage and polyadenylation specificity factor (CPSF73).
Role of PSO genes in the repair of photoinduced interstrand cross-links and photooxidative damage in the DNA of the yeast Saccharomyces cerevisiae.
Review
Brendel et al., Porto Alegre, Brazil. In J Photochem Photobiol B, 1997
Recent progress in elucidating the molecular structure of the PSSO genes PSO2 to PSO7 is presented.
Mutant Gene snm2-1 (ts), conferring thermoconditional mutagen sensitivity in Saccharomyces cerevisiae, is allelic with RAD5.
Brendel et al., Frankfurt am Main, Germany. In Curr Genet, 1982
Of two mutant genes (snm1-2 (ts) and snm2-1 (ts)) conferring thermoconditional mutagen sensitivity in Saccharomyces cerevisiae one (snm2-1 (ts)) is shown to be centromere-linked.
Interactions among genes controlling sensitivity to radiation (RAD) and to alkylation by nitrogen mustard (SNM) in yeast.
Brendel et al., Frankfurt am Main, Germany. In Curr Genet, 1982
From the observed epistatic or synergistic interactions of the combinations of mutant alleles we could derive the relation of the SNM1 and SNM2 genes to the postulated repair pathways.
Isolation and characterization of yeast mutants with thermoconditional sensitivity to the bifunctional alkylating agent nitrogen mustard.
Brendel et al., Frankfurt am Main, Germany. In Curr Genet, 1981
Mutant allele snm1-2 (ts) showed mainly ts-sensitivity to HN2, whereas mutant allele snm2-1 (ts) conferred ts-sensitivity to HN2, half mustard (HN1) and UV.
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