The protein encoded by this gene is a member of the polo family of serine/threonine protein kinases that have a role in normal cell division. This gene is most abundantly expressed in testis, spleen and fetal tissues, and its expression is inducible by serum, suggesting that it may also play an important role in cells undergoing rapid cell division. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011] (from
Kim et al., Seoul, South Korea. In Ann Oncol, Jan 2016
We suspected that these events were associated with Epstein-Barr virus (EBV) reactivation because of the rapidly elevated EBV DNA titers in blood from these patients.An in vitro study with the ENKTL cell line SNK-6 cells also showed that histone deacetylase inhibitors including romidepsin increased the copy number of EBV DNA in a dose-dependent manner.
Molloy et al., Australia. In Int J Radiat Oncol Biol Phys, Jan 2016
The expression of putative microRNA target biomarkers-TOP2A, POLQ, RAD54L, SKP2, PLK2, and RAG1-were correlated with standard clinicopathologic variables using 2-sided nonparametric tests, and to local/distant relapse and survival using Kaplan-Meier and Cox regression analysis.
Reddy et al., New York City, United States. In Bioorg Med Chem, Jan 2016
PLK2 (SNK), which is highly homologous to PLK1, has been shown to play a critical role in centriole duplication and is also believed to play a regulatory role in the survival pathway by physically stabilizing the TSC1/2 complex in tumor cells under hypoxic conditions.
Sheng et al., Cambridge, United States. In Science, 2003
induction in hippocampal neurons eliminated SPAR protein, depleted PSD-95 and Bassoon clusters & caused loss of mature dendritic spines; results implicate SNK as a mediator of activity-dependent change in the molecular composition & morphology of synapses