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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

NUAK family, SNF1-like kinase, 2

SNARK, Snf1/AMP-activated protein kinase, NUAK2
Top mentioned proteins: AMPK, ARK5, LKB1, HAD, CAN
Papers on SNARK
The AMPK-related kinase SNARK regulates muscle mass and myocyte survival.
New
Goodyear et al., In J Clin Invest, Jan 2016
We found that expression of a member of the AMPK-related kinase family, the SNF1-AMPK-related kinase (SNARK, also known as NUAK2), increased with muscle cell differentiation.
NUAK2 Amplification Coupled with PTEN Deficiency Promotes Melanoma Development via CDK Activation.
New
Hearing et al., Tokyo, Japan. In Cancer Res, Aug 2015
The AMPK-related kinase NUAK2 has been implicated in melanoma growth and survival outcomes, but its therapeutic utility has yet to be confirmed.
Snf1/AMP-activated protein kinase activates Arf3p to promote invasive yeast growth via a non-canonical GEF domain.
Lee et al., Taipei, Taiwan. In Nat Commun, 2014
Active GTP-bound Arf GTPases promote eukaryotic cell membrane trafficking and cytoskeletal remodelling.
Violence and mental illness: what Lewis Carroll had to say.
Miller et al., United States. In Schizophr Res, 2014
One year later, Carroll began writing The Hunting of the Snark, a poem whose meaning has mystified Carroll enthusiasts.
Interplay between Polo kinase, LKB1-activated NUAK1 kinase, PP1βMYPT1 phosphatase complex and the SCFβTrCP E3 ubiquitin ligase.
Alessi et al., Dundee, United Kingdom. In Biochem J, 2014
NUAK1 (NUAK family SnF1-like kinase-1) and NUAK2 protein kinases are activated by the LKB1 tumour suppressor and have been implicated in regulating multiple processes such as cell survival, senescence, adhesion and polarity.
Characterization of WZ4003 and HTH-01-015 as selective inhibitors of the LKB1-tumour-suppressor-activated NUAK kinases.
Gray et al., Dundee, United Kingdom. In Biochem J, 2014
The related NUAK1 and NUAK2 are members of the AMPK (AMP-activated protein kinase) family of protein kinases that are activated by the LKB1 (liver kinase B1) tumour suppressor kinase.
Snf1 is a regulator of lipid accumulation in Yarrowia lipolytica.
Hong et al., Wilmington, United States. In Appl Environ Microbiol, 2013
This work presents a new role for Snf1/AMP-activated protein kinase (AMPK) pathways in lipid accumulation in this oleaginous yeast.
Analysis of NUAK1 and NUAK2 expression during early chick development reveals specific patterns in the developing head.
Thélu et al., Grenoble, France. In Int J Dev Biol, 2013
Several human diseases are associated with the NUAK1 and NUAK2 genes.
Meglumine exerts protective effects against features of metabolic syndrome and type II diabetes.
Prendergast et al., United States. In Plos One, 2013
Sorbitol can improve blood glucose uptake by liver and muscle in a manner associated with upregulation of the AMPK-related enzyme SNARK, but with undesirable gastrointestinal side effects not seen with meglumine.
The regulation and function of the NUAK family.
Review
Zhao et al., Taipei, Taiwan. In J Mol Endocrinol, 2013
Twelve AMPK-related kinases (ARKs; BRSK1, BRSK2, NUAK1, NUAK2, QIK, QSK, SIK, MARK1, MARK2, MARK3, MARK4, and MELK) have been identified recently.
NUAK2: an emerging acral melanoma oncogene.
Review
GeneRIF
Hearing et al., Bethesda, United States. In Oncotarget, 2011
Considers possible roles of NUAK2 in tumorigenesis in general and suggest that NUAK2 has pivotal roles in acral melanomagenesis.
AMP kinase-related kinase NUAK2 affects tumor growth, migration, and clinical outcome of human melanoma.
GeneRIF
Hearing et al., Bethesda, United States. In Proc Natl Acad Sci U S A, 2011
This study further supports the importance of NUAK2 in cancer development and tumor progression, while AMPK has antioncogenic properties.
An association between NUAK2 and MRIP reveals a novel mechanism for regulation of actin stress fibers.
GeneRIF
Mäkelä et al., Helsinki, Finland. In J Cell Sci, 2011
MLCP (myosin light chain phosphatase) activation is counteracted by a previously unrecognized association between MRIP (myosin phosphatase Rho-interacting protein) and the inducible kinase NUAK2
Sucrose nonfermenting AMPK-related kinase (SNARK) mediates contraction-stimulated glucose transport in mouse skeletal muscle.
GeneRIF
Goodyear et al., Boston, United States. In Proc Natl Acad Sci U S A, 2010
Data show that SNARK is activated by muscle contraction and is a unique mediator of contraction-stimulated glucose transport in skeletal muscle.
Regulation of skeletal muscle sucrose, non-fermenting 1/AMP-activated protein kinase-related kinase (SNARK) by metabolic stress and diabetes.
GeneRIF
Zierath et al., Stockholm, Sweden. In Diabetologia, 2009
Skeletal muscle SNARK expression is increased in human obesity, and in response to metabolic stressors, but not type 2 diabetes. Partial SNARK depletion failed to modify either glucose or lipid metabolism.
The regulation and function of mammalian AMPK-related kinases.
Review
Carling et al., London, United Kingdom. In Acta Physiol (oxf), 2009
Recently, 12 AMPK-related kinases (BRSK1, BRSK2, NUAK1, NUAK2, QIK, QSK, SIK, MARK1, MARK2, MARK3, MARK4 and MELK) were identified that are closely related by sequence homology to the catalytic domain of AMPK.
The evolution of comparative cognition: is the snark still a boojum?
Review
Shettleworth, Toronto, Canada. In Behav Processes, 2009
In "The Snark is a Boojum", Beach [Beach, F.A., 1950.
Cytometry in monoclonal B-cell lymphocytosis and chronic lymphocytic leukaemia--the Hunting of the Snark?
Review
Shapiro, Newton, United States. In Br J Haematol, 2007
Cytometry has become important in the detection and determination of risk of monoclonal B-cell lymphocytosis; methodology has changed, and will continue to change, as cytometric technology changes.
AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy.
Review
Impact
Hardie, Dundee, United Kingdom. In Nat Rev Mol Cell Biol, 2007
The SNF1/AMP-activated protein kinase (AMPK) family maintains the balance between ATP production and consumption in all eukaryotic cells.
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