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Small nuclear RNA activating complex, polypeptide 2, 45kDa

SNAP45, PTF delta
This gene encodes a subunit of the snRNA-activating protein complex which is associated with the TATA box-binding protein. The encoded protein is necessary for RNA polymerase II and III dependent small-nuclear RNA gene transcription. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009] (from NCBI)
Top mentioned proteins: PDEF, POLYMERASE, SNAP43, SNAP50, TBP
Papers on SNAP45
Replication stress induces 53BP1-containing OPT domains in G1 cells.
GeneRIF
Jackson et al., Cambridge, United Kingdom. In J Cell Biol, 2011
The findings invoke a model wherein incomplete DNA synthesis during S phase leads to a DNA damage response and formation of 53BP1-OPT domains in the subsequent G1.
Mitotic functions for SNAP45, a subunit of the small nuclear RNA-activating protein complex SNAPc.
GeneRIF
Hernandez et al., United States. In J Biol Chem, 2008
SNAP45 plays two roles in the cell, one as a subunit of the transcription factor SNAP(c) and another as a factor required for proper mitotic progression
Co-expression of multiple subunits enables recombinant SNAPC assembly and function for transcription by human RNA polymerases II and III.
Henry et al., East Lansing, United States. In Protein Expr Purif, 2006
SNAP(C) consists of five subunits: SNAP190, SNAP50, SNAP45, SNAP43, and SNAP19.
Redundant cooperative interactions for assembly of a human U6 transcription initiation complex.
Hernandez et al., New York City, United States. In Mol Cell Biol, 2002
The PSE is recognized by the snRNA-activating protein complex (SNAP(c)), which consists of five types of subunits, SNAP190, SNAP50, SNAP45, SNAP43, and SNAP19.
A map of protein-protein contacts within the small nuclear RNA-activating protein complex SNAPc.
Hernandez et al., United States. In J Biol Chem, 2001
This factor, the snRNA-activating protein complex or SNAP(c), binds to the PSE of both types of promoters and contains five types of subunits, SNAP190, SNAP50, SNAP45, SNAP43, and SNAP19.
SNAP19 mediates the assembly of a functional core promoter complex (SNAPc) shared by RNA polymerases II and III.
Hernandez et al., New York City, United States. In Genes Dev, 1998
Here we reconstitute SNAPc from five recombinant subunits, SNAP43, SNAP45, SNAP50, SNAP190, and a newly identified subunit, SNAP19.
The large subunit of basal transcription factor SNAPc is a Myb domain protein that interacts with Oct-1.
Hernandez et al., New York City, United States. In Mol Cell Biol, 1998
SNAPc consists of at least four stably associated subunits, SNAP43, SNAP45, SNAP50, and SNAP190.
Cloning and characterization of SNAP50, a subunit of the snRNA-activating protein complex SNAPc.
Hernandez et al., United States. In Embo J, 1997
cDNAs encoding the 43 and 45 kDa subunits, SNAP43 and SNAP45, have been isolated, but there is no evidence that either of these subunits contacts DNA.
Cloning and characterization of the beta subunit of human proximal sequence element-binding transcription factor and its involvement in transcription of small nuclear RNA genes by RNA polymerases II and III.
Roeder et al., New York City, United States. In Mol Cell Biol, 1996
Along with our previous demonstration of both physical interactions between PTF gamma/PTF delta and TBP and the involvement of TFIIIB90 in the transcription of class III snRNA genes, these results are consistent with the notion that a TBP-containing complex related to TFIIIB is required for the transcription of class III snRNA genes, and acts through weak interaction with the four-subunit PTF.
Cloning of two proximal sequence element-binding transcription factor subunits (gamma and delta) that are required for transcription of small nuclear RNA genes by RNA polymerases II and III and interact with the TATA-binding protein.
Roeder et al., New York City, United States. In Mol Cell Biol, 1996
We now report the isolation and expression of cDNAs encoding PTF gamma and PTF delta, as well as functional studies with cognate antibodies that recognize the native PTF complex in HeLa extracts.
A TBP-TAF complex required for transcription of human snRNA genes by RNA polymerase II and III.
Impact
Hernandez et al., New York City, United States. In Nature, 1995
In addition to TBP, SNAPc is composed of at least three TAFs, SNAP43, SNAP45 and SNAP50.
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