Quantitative profiling of the activity of protein lysine methyltransferase SMYD2 using SILAC-based proteomics.
United States. In Mol Cell Proteomics, Feb 2016
UNASSIGNED: The significance of non-histone lysine methylation in cell biology and human disease is an emerging area of research exploration, and the development of small molecule inhibitors that selectively and potently target enzymes that catalyze the addition of methyl-groups to lysine residues, such as the protein lysine mono-methyltransferase SMYD2, is an active area of drug discovery.
p53 is regulated by the lysine demethylase LSD1.
Philadelphia, United States. In Nature, 2007
We find that, in vitro, LSD1 removes both monomethylation (K370me1) and dimethylation (K370me2) at K370, a previously identified Smyd2-dependent monomethylation site.