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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

SMAD specific E3 ubiquitin protein ligase 2

Smurf2
Top mentioned proteins: Ubiquitin, Smad7, Smad2, Smad3, CAN
Papers using Smurf2 antibodies
Age-related changes in the osteogenic differentiation potential of mouse bone marrow stromal cells.
Supplier
Shi Songtao, In PLoS ONE, 2007
... antibody (#ab22552) from Abcam Inc.; Runx2 (#130-3) monoclonal antibody from MBL International; Smurf1 (#AP2104a) and Smurf2 (#AP2105a) antibodies from Abgent Inc.; ERK1/2 (#9102) and ...
Papers on Smurf2
miR-15b promotes epithelial-mesenchymal transition by inhibiting SMURF2 in pancreatic cancer.
New
Lv et al., Beijing, China. In Int J Oncol, Sep 2015
We report here that silencing SMURF2 (SMAD specific E3 ubiquitin protein ligase 2) promoted EMT in HPDE6c7 normal pancreas cells and overexpression of SMURF2 inhibited TGF-β-mediated EMT in the cells.
Ubiquitin in regulation of spindle apparatus and its positioning: implications in development and disease.
Review
New
Chakrabarti et al., Calcutta, India. In Biochem Cell Biol, Aug 2015
Some of the ubiquitin ligases regulating these proteins include PARK2, BRCA1/BARD1, MGRN1, SMURF2, and SIAH1; these play a pivotal role in the correct positioning of the spindle apparatus.
TRAF4-SMURF2-mediated DAZAP2 degradation is critical for IL-25 signaling and allergic airway inflammation.
New
Li et al., San Francisco, United States. In J Immunol, Apr 2015
Mechanistically, TRAF4 recruited the E3-ligase SMURF2, to degrade the IL-25R-inhibitory molecule DAZAP2.
USP15 regulates SMURF2 kinetics through C-lobe mediated deubiquitination.
Eichhorn et al., Singapore, Singapore. In Sci Rep, 2014
To limit TGF-β responses, TGF-β signaling is regulated through a negative feedback loop whereby the E3 ligase SMURF2 targets the TGF-β receptor (TβR) complex for ubiquitin-mediated degradation.
Smad7 inhibits AngII-mediated hypertensive nephropathy in a mouse model of hypertension.
Lan et al., Huizhou, China. In Clin Sci (lond), 2014
These preventive and therapeutic effects of SMAD7 on hypertensive kidney injury were associated with inhibition of AngII-induced up-regulation of SMURF2 (SMAD-specific E3 ubiquitin protein ligase 2) and Sp1 (specificity protein 1), blockade of TGFβ/Smad3-mediated renal fibrosis and suppression of NF-κB-driven renal inflammation.
Novel effects of rosiglitazone on SMAD2 and SMAD3 signaling in white adipose tissue of diabetic rats.
Wright et al., Guelph, Canada. In Obesity (silver Spring), 2014
ZDF ROSI exhibited decreased phosphorylation of SMAD2 and SMAD3 exclusively in scWAT, along with increases in inhibitory SMAD7 and the E3 ubiquitin ligase SMURF2.
KRAS protein stability is regulated through SMURF2: UBCH5 complex-mediated β-TrCP1 degradation.
Ray et al., Ann Arbor, United States. In Neoplasia, 2014
Here, we report the identification of Smad ubiquitination regulatory factor 2 (SMURF2) and UBCH5 as a critical E3:E2 complex maintaining KRAS protein stability.
Expression of mesenchymal stem cells-related genes and plasticity of aspirated follicular cells obtained from infertile women.
Virant-Klun et al., Ljubljana, Slovenia. In Biomed Res Int, 2013
Altogether the expression of 57 genes was detected in AFCs: 16 genes (OCT4, CD49f, CD106, CD146, CD45, CD54, IL10, IL1B, TNF, VEGF, VWF, HDAC1, MITF, RUNX2, PPARG, and PCAF) were upregulated and 20 genes (FGF2, CASP3, CD105, CD13, CD340, CD73, CD90, KDR, PDGFRB, BDNF, COL1A1, IL6, MMP2, NES, NUDT6, BMP6, SMURF2, BMP4, GDF5, and JAG1) were downregulated in AFCs when compared with BM-MSCs.
Functional networks of nucleocytoplasmic transport-related genes differentiate ischemic and dilated cardiomyopathies. A new therapeutic opportunity.
Rivera et al., Valencia, Spain. In Plos One, 2013
DDX3X, KPNA2, and PTK2B were related to ICM, while SMURF2, NUP153, IPO5, RANBP3, NOXA1, and RHOJ were involved in DCM pathogenesis.
Downregulation of Smurf2, a tumor-suppressive ubiquitin ligase, in triple-negative breast cancers: involvement of the RB-microRNA axis.
Kiyokawa et al., Chicago, United States. In Bmc Cancer, 2013
BACKGROUND: The HECT family ubiquitin ligase Smurf2 regulates cell polarity, migration, division, differentiation and death, by targeting diverse substrates that are critical for receptor signaling, cytoskeleton, chromatin remodeling and transcription.
TRAF4 promotes TGF-β receptor signaling and drives breast cancer metastasis.
Ten Dijke et al., Leiden, Netherlands. In Mol Cell, 2013
Upon TGF-β stimulation, TRAF4 is recruited to the active TGF-β receptor complex, where it antagonizes E3 ligase SMURF2 and facilitates the recruitment of deubiquitinase USP15 to the TGF-β type I receptor (TβRI).
Lysine-specific demethylase 1 (LSD1/KDM1A) contributes to colorectal tumorigenesis via activation of the Wnt/β-catenin pathway by down-regulating Dickkopf-1 (DKK1) [corrected].
Wang et al., Beijing, China. In Plos One, 2012
We then selected the 4 colorectal cancer-related genes ADM, DKK1, HAS3 and SMURF2 for quantitative real-time PCR verification.
Genome wide association and linkage analyses identified three loci-4q25, 17q23.2, and 10q11.21-associated with variation in leukocyte telomere length: the Long Life Family Study.
Mayeux et al., New York City, United States. In Front Genet, 2012
These two loci harbor a number of novel candidate genes with SNPs, and our gene-wise association analysis identified multiple genes, including DCAF7, POLG2, CEP95, and SMURF2 at 17q23.2; and RASGEF1A, HNRNPF, ANF487, CSTF2T, and PRKG1 at 10q11.21.
USP4 is regulated by AKT phosphorylation and directly deubiquitylates TGF-β type I receptor.
Impact
ten Dijke et al., Leiden, Netherlands. In Nat Cell Biol, 2012
TβRI is targeted for ubiquitylation-mediated degradation by the SMAD7-SMURF2 complex.
Smurf2 regulates the senescence response and suppresses tumorigenesis in mice.
GeneRIF
Zhang et al., Worcester, United States. In Cancer Res, 2012
Smurf2 deficiency increased the susceptibility of mice to spontaneous tumorigenesis, most notably B-cell lymphoma
Overexpression of Smad ubiquitin regulatory factor 2 suppresses transforming growth factor-β mediated liver fibrosis.
GeneRIF
Shen et al., Shanghai, China. In J Dig Dis, 2012
Smurf2 interacts with Smad7 to suppress TGF-beta-mediated liver fibrosis through the ubiquitin-dependent degradation of TbetaRI during the early period of liver fibrosis.
A variant of Smurf2 protects mice against colitis-associated colon cancer by inducing transforming growth factor β signaling.
GeneRIF
Neurath et al., Nürnberg, Germany. In Gastroenterology, 2012
T cell-specific DeltaE2Smurf2 degrades wild-type Smurf2 and controls intestinal tumor growth in mice by up-regulating TGF-beta receptor type II, reducing proliferation and production of proinflammatory cytokines.
Transcriptional induction of salt-inducible kinase 1 by transforming growth factor β leads to negative regulation of type I receptor signaling in cooperation with the Smurf2 ubiquitin ligase.
GeneRIF
Moustakas et al., Uppsala, Sweden. In J Biol Chem, 2012
TGFbeta induces expression of Smad7, Smurf2, and SIK1, the products of which physically and functionally interlink to control the activity of this pathway.
USP15 stabilizes TGF-β receptor I and promotes oncogenesis through the activation of TGF-β signaling in glioblastoma.
Impact
Seoane et al., Barcelona, Spain. In Nat Med, 2012
USP15 binds to the SMAD7-SMAD specific E3 ubiquitin protein ligase 2 (SMURF2) complex and deubiquitinates and stabilizes type I TGF-β receptor (TβR-I), leading to an enhanced TGF-β signal.
A tumor suppressor function of Smurf2 associated with controlling chromatin landscape and genome stability through RNF20.
Impact
GeneRIF
Zhang et al., Bethesda, United States. In Nat Med, 2012
tumor suppression function that maintains genomic stability by control of the epigenetic landscape of histone modifications through RNF20
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