Melatonin, bone regulation and the ubiquitin-proteasome connection: A review.
Winnipeg, Canada. In Life Sci, Jan 2016
The ubiquitin ligases that are reported to be of major significance in regulating these pathways are the ubiquitin SCF(B-TrCP) ligase (which regulates activation of NF-κB via degradation of IkBα in osteoclasts, and regulates bone transcription factors via degradation of β-catenin), the Keap-Cul3-Rbx1 ligase (which regulates degradation of IkB kinase, Nrf2, and the antiapoptotic factor Bcl-2), and Smurf1.
Genomic profiling of invasive melanoma cell lines by array comparative genomic hybridization.
Debrecen, Hungary. In Melanoma Res, Jan 2016
Invasive primary cell lines showed high frequencies of CNAs, including the loss of 7q and gain of 12q chromosomal regions targeting PTPN12, ADAM22, FZD1, TFPI2, GNG11, COL1A2, SMURF1, VGF, RELN and GLIPR1 genes.
Smurf1 zaps the talin head.
In Nat Cell Biol, 2009
New results show that the talin head liberated from talin by calpain II cleavage has a key role in these events, and that its levels are tightly regulated by Smurf1-mediated ubiquitylation counteracted by Cdk5-mediated phosphorylation.