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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 25 Jan 2016.

SMT3 Smt3p

Smt3, SUMO, Smt3p, Pmt3
Top mentioned proteins: Ubiquitin, CAN, DAPI, SUMO-2, Ubc9
Papers using Smt3 antibodies
Evidence for heme-mediated redox regulation of human cystathionine beta-synthase activity.
Supplier
Cobine Paul, In PLoS ONE, 1997
... Aos1/ Uba2, Ubc9, SUMO-1 and SUMO-1 rabbit monoclonal antibody were purchased with the SUMOlink kit from Active Motif, Carlsbad, CA ...
Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation
Supplier
Malumbres Marcos et al., In Frontiers in Oncology, 1997
... SUMOylation of recombinant Aurora-A protein was tested using Active Motif SUMO link (Active Motif, #40120) and following manufacturer’s ...
SUMO-2/3 regulates topoisomerase II in mitosis
Supplier
Dasso Mary et al., In The Journal of Cell Biology, 1986
... The processed and full-length forms of SUMO-2 and -3 were cloned into pGEX4T-1, fused at their NH2 termini to an EGFP fragment that was excised from a pEGFP C-1 plasmid (CLONTECH Laboratories, Inc.) ...
Papers on Smt3
Putative role of SUMOylation in controlling the activity of deubiquitinating enzymes in cancer.
New
Massoumi et al., Lund, Sweden. In Future Oncol, 18 Feb 2016
SUMOylations consist of the conjugation of the small peptide SUMO to protein substrates which is very similar to ubiquitination in the mechanistic and machinery required.
Synthesis of a Bis-thio-acetone (BTA) Analogue of the Lysine Isopeptide Bond and its Application to Investigate the Effects of Ubiquitination and SUMOylation on α-Synuclein Aggregation and Toxicity.
New
Pratt et al., Los Angeles, United States. In Acs Chem Biol, 12 Feb 2016
Additionally, we apply this technique to the preparation of the aggregation prone protein α-synuclein bearing either ubiquitin or the small ubiquitin-like modifier (SUMO).
S. cerevisiae Mre11 recruits conjugated SUMO moieties to facilitate the assembly and function of the Mre11-Rad50-Xrs2 complex.
New
Wang et al., Taipei, Taiwan. In Nucleic Acids Res, 06 Feb 2016
However, the molecular mechanism of this SUMO-mediated response is not completely known.
Molecular Basis for Phosphorylation Dependent SUMO Recognition by the DNA Repair Protein RAP80.
New
Spyracopoulos et al., Canada. In J Biol Chem, 30 Jan 2016
UNASSIGNED: Recognition and repair of double stranded DNA breaks (DSB) involves the targeted recruitment of BRCA tumor suppressors to damage foci through binding of both ubiquitin (Ub) and the Ub-like modifier SUMO.
Glucocorticoid-induced tethered transrepression requires SUMOylation of GR and formation of a SUMO-SMRT/NCoR1-HDAC3 repressing complex.
New
Chambon et al., Illkirch-Graffenstaden, France. In Proc Natl Acad Sci U S A, 28 Jan 2016
UNASSIGNED: Upon binding of a glucocorticoid (GC), the GC receptor (GR) can exert one of three transcriptional regulatory functions.
Sumoylation coordinates the repression of inflammatory and anti-viral gene-expression programs during innate sensing.
New
Impact
Dejean et al., Paris, France. In Nat Immunol, 14 Jan 2016
Mechanistically, the small ubiquitin-like modifier SUMO operated from a distal enhancer of the gene encoding interferon-β (Ifnb1) to silence both basal and stimulus-induced activity of the Ifnb1 promoter.
Nutritional conditions regulate transcriptional activity of SF-1 by controlling sumoylation and ubiquitination.
New
Elmquist et al., Dallas, United States. In Sci Rep, 31 Dec 2015
Under normal conditions, the transcriptional activity of hypothalamic SF-1 was activated by SUMO, but this was attenuated during starvation.
Heterochromatic breaks move to the nuclear periphery to continue recombinational repair.
New
Impact
Chiolo et al., Los Angeles, United States. In Nat Cell Biol, Nov 2015
Both the initial block to HR progression inside the heterochromatin domain, and the targeting of repair sites to the nuclear periphery, rely on SUMO and SUMO E3 ligases.
TCR-induced sumoylation of the kinase PKC-θ controls T cell synapse organization and T cell activation.
New
Impact
Li et al., Guangzhou, China. In Nat Immunol, Nov 2015
We identified the SUMO E3 ligase PIASxβ as a ligase for PKC-θ.
[Effects of SUMO specific protease 1 on hPXR-mediated P-gp gene expression].
New
Chen et al., In Yao Xue Xue Bao, Sep 2015
The study aimed to investigate the effects of small ubiquitin-related modifier (SUMO) specific protease 1 (SENP1) on human PXR-mediated MDR1 transcriptional activity and mRNA expression.
[Research Progress in the Core Proteins of the Classical Swine Fever Virus].
New
Zhang et al., In Bing Du Xue Bao, Sep 2015
In this review, we combine study of this protein with its disorders, structural/functional characteristics, as well as its interactions with the non-structural proteins NS3, NS5B and host proteins such as SUMO-1, UBC9, OS9 and IQGAP1.
Evaluation of a SUMO E2 Conjugating Enzyme Involved in Resistance to Clavibacter michiganensis Subsp. michiganensis in Solanum peruvianum, Through a Tomato Mottle Virus VIGS Assay.
Alpuche-Solís et al., San Luis Potosí, Mexico. In Front Plant Sci, 2014
Previous research showed up-regulation of a SUMO E2 conjugating enzyme (SCEI) transcript in S. peruvianum compared to S. lycopersicum following infection with Cmm.
Neuronal SUMOylation: mechanisms, physiology, and roles in neuronal dysfunction.
Impact
Wilkinson et al., Bristol, United Kingdom. In Physiol Rev, 2014
Hundreds of different proteins are SUMO substrates, and dysfunction of protein SUMOylation is implicated in a many different diseases.
Weighing up the possibilities: Controlling translation by ubiquitylation and sumoylation.
Morley et al., Brighton, United Kingdom. In Translation (austin), 2014
Both of these events can be regulated by post-translational modification by ubiquitin or Ubls (ubiquitin-like modifiers) such as SUMO or ISG15.
Sumoylation pathway is required to maintain the basal breast cancer subtype.
Impact
Weigel et al., Iowa City, United States. In Cancer Cell, 2014
Disruption of the sumoylation pathway by knockdown of sumoylation enzymes, mutation of the SUMO-target lysine of TFAP2A, or treatment with sumoylation inhibitors induced a basal-to-luminal transition, which was dependent on TFAP2A.
Drosophila Smt3 negatively regulates JNK signaling through sequestering Hipk in the nucleus.
GeneRIF
Jiao et al., Beijing, China. In Development, 2011
although knockdown of the homeodomain-interacting protein kinase (Hipk) suppresses Smt3 depletion-induced activation of JNK, Hipk overexpression synergistically enhances this type of JNK activation
Ubiquitin-proteasome genes as targets for modulation of cisplatin sensitivity in fission yeast.
GeneRIF
Perego et al., Milano, Italy. In Bmc Genomics, 2010
Data show that pmt3 mutants exhibiting hypersensitivity to cisplatin.
Role of the Zn(2+) motif of E1 in SUMO adenylation.
GeneRIF
Chen et al., Duarte, United States. In J Biol Chem, 2010
the Zn(2+) motif of E1 has a role in SUMO adenylation
Cdk1 and SUMO regulate Swe1 stability.
GeneRIF
Brandeis et al., Jerusalem, Israel. In Plos One, 2009
Cdk1 and SUMO (Smt3) regulate Swe1 stability
Genetic and proteomic evidence for roles of Drosophila SUMO in cell cycle control, Ras signaling, and early pattern formation.
GeneRIF
Courey et al., Los Angeles, United States. In Plos One, 2008
SUMO coordinates multiple regulatory processes during oogenesis and early embryogenesis
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