SUMO-2/3 regulates topoisomerase II in mitosis
In The Journal of Cell Biology, 1986
... The processed and full-length forms of SUMO-2 and -3 were cloned into pGEX4T-1, fused at their NH2 termini to an EGFP fragment that was excised from a pEGFP C-1 plasmid (CLONTECH Laboratories, Inc.) ...
Engineering pre-SUMO4 as efficient substrate of SENP2.
Riverside, United States. In Protein Eng Des Sel, Apr 2014
SENP (Sentrin/SUMO-specific protease), a family of SUMO-specific proteases, is responsible for the processing of pre-SUMO and removal of SUMO from conjugated substrates.
E3 ubiquitin ligases in regulating stress fiber, lamellipodium, and focal adhesion dynamics.
Lexington, United States. In Cell Adh Migr, Jan 2014
HACE1, XIAP, and Skp1-Cul1-F-box bind to Rac1 and cause its ubiquitination and degradation, thus suppressing lamellipodium protrusions, while PIAS3, a SUMO ligase, activates Rac1 to promote lamellipodium dynamics.
Dynamic regulation of steroid hormone receptor transcriptional activity by reversible SUMOylation.
Minneapolis, United States. In Vitam Horm, 2012
Many factors may influence SR promoter selectivity, including chromatin structure, cofactor availability, and posttranslational modifications to SRs and/or their numerous coregulators; this review focuses on the impact that covalent attachment of small ubiquitin-like modifier (SUMO) moieties to SRs (i.e., SUMOylation) have on the transcriptional regulation of SR target genes.