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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 21 May 2016.

SMT3 Smt3p

Smt3, SUMO, Smt3p, Pmt3
Top mentioned proteins: Ubiquitin, CAN, DAPI, SUMO-2, Ubc9
Papers using Smt3 antibodies
Evidence for heme-mediated redox regulation of human cystathionine beta-synthase activity.
Supplier
Cobine Paul, In PLoS ONE, 1997
... Aos1/ Uba2, Ubc9, SUMO-1 and SUMO-1 rabbit monoclonal antibody were purchased with the SUMOlink kit from Active Motif, Carlsbad, CA ...
Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation
Supplier
Malumbres Marcos et al., In Frontiers in Oncology, 1997
... SUMOylation of recombinant Aurora-A protein was tested using Active Motif SUMO link (Active Motif, #40120) and following manufacturer’s ...
SUMO-2/3 regulates topoisomerase II in mitosis
Supplier
Dasso Mary et al., In The Journal of Cell Biology, 1986
... The processed and full-length forms of SUMO-2 and -3 were cloned into pGEX4T-1, fused at their NH2 termini to an EGFP fragment that was excised from a pEGFP C-1 plasmid (CLONTECH Laboratories, Inc.) ...
Papers on Smt3
Sumoylation coordinates the repression of inflammatory and anti-viral gene-expression programs during innate sensing.
New
Impact
Dejean et al., Paris, France. In Nat Immunol, Feb 2016
Mechanistically, the small ubiquitin-like modifier SUMO operated from a distal enhancer of the gene encoding interferon-β (Ifnb1) to silence both basal and stimulus-induced activity of the Ifnb1 promoter.
Putative role of SUMOylation in controlling the activity of deubiquitinating enzymes in cancer.
New
Massoumi et al., Lund, Sweden. In Future Oncol, Feb 2016
SUMOylations consist of the conjugation of the small peptide SUMO to protein substrates which is very similar to ubiquitination in the mechanistic and machinery required.
S. cerevisiae Mre11 recruits conjugated SUMO moieties to facilitate the assembly and function of the Mre11-Rad50-Xrs2 complex.
New
Wang et al., Taipei, Taiwan. In Nucleic Acids Res, Feb 2016
However, the molecular mechanism of this SUMO-mediated response is not completely known.
Roles for SUMO in pre-mRNA processing.
Review
New
Parvin et al., Columbus, United States. In Wiley Interdiscip Rev Rna, Jan 2016
When the small ubiquitin-like modifier (SUMO)-1 protein is localized on the genome, it is found on proteins bound to the promoters of the most highly active genes and on proteins bound to the DNA-encoding exons.
Nutritional conditions regulate transcriptional activity of SF-1 by controlling sumoylation and ubiquitination.
New
Elmquist et al., Dallas, United States. In Sci Rep, Dec 2015
Under normal conditions, the transcriptional activity of hypothalamic SF-1 was activated by SUMO, but this was attenuated during starvation.
SUMOylation-Mediated Regulation of Cell Cycle Progression and Cancer.
Review
New
Vertegaal et al., Leiden, Netherlands. In Trends Biochem Sci, Dec 2015
Protein conjugation with Small ubiquitin-like modifier (SUMOylation) has critical roles during cell cycle progression.
Crystal structure and SUMO binding of Slx1-Slx4 complex.
New
Qian et al., Hong Kong, Hong Kong. In Sci Rep, Dec 2015
Furthermore, we found the C-terminal tail of S. pombe Slx1 contains a SUMO-interacting motif and can recognize Pmt3 (S. pombe SUMO), suggesting that Slx1-Slx4 complex could be recruited by SUMOylated protein targets to take part in replication associated DNA repair processes.
Divergent signaling via SUMO modification: Potential for CFTR modulation.
Review
New
Frizzell et al., Pittsburgh, United States. In Am J Physiol Cell Physiol, Dec 2015
A new pathway that contributes to mutant CFTR degradation is mediated by the small heat shock protein, Hsp27, which cooperates with Ubc9, the E2 enzyme for SUMOylation, to selectively conjugate mutant CFTR with SUMO-2/3.
TCR-induced sumoylation of the kinase PKC-θ controls T cell synapse organization and T cell activation.
New
Impact
Li et al., Guangzhou, China. In Nat Immunol, Nov 2015
We identified the SUMO E3 ligase PIASxβ as a ligase for PKC-θ.
Heterochromatic breaks move to the nuclear periphery to continue recombinational repair.
New
Impact
Chiolo et al., Los Angeles, United States. In Nat Cell Biol, Nov 2015
Both the initial block to HR progression inside the heterochromatin domain, and the targeting of repair sites to the nuclear periphery, rely on SUMO and SUMO E3 ligases.
[Research Progress in the Core Proteins of the Classical Swine Fever Virus].
Review
New
Zhang et al., In Bing Du Xue Bao, Sep 2015
In this review, we combine study of this protein with its disorders, structural/functional characteristics, as well as its interactions with the non-structural proteins NS3, NS5B and host proteins such as SUMO-1, UBC9, OS9 and IQGAP1.
[Effects of SUMO specific protease 1 on hPXR-mediated P-gp gene expression].
New
Chen et al., In Yao Xue Xue Bao, Sep 2015
The study aimed to investigate the effects of small ubiquitin-related modifier (SUMO) specific protease 1 (SENP1) on human PXR-mediated MDR1 transcriptional activity and mRNA expression.
Neuronal SUMOylation: mechanisms, physiology, and roles in neuronal dysfunction.
Review
Impact
Wilkinson et al., Bristol, United Kingdom. In Physiol Rev, 2014
Hundreds of different proteins are SUMO substrates, and dysfunction of protein SUMOylation is implicated in a many different diseases.
Weighing up the possibilities: Controlling translation by ubiquitylation and sumoylation.
Review
Morley et al., Brighton, United Kingdom. In Translation (austin), 2014
Both of these events can be regulated by post-translational modification by ubiquitin or Ubls (ubiquitin-like modifiers) such as SUMO or ISG15.
Sumoylation pathway is required to maintain the basal breast cancer subtype.
Impact
Weigel et al., Iowa City, United States. In Cancer Cell, 2014
Disruption of the sumoylation pathway by knockdown of sumoylation enzymes, mutation of the SUMO-target lysine of TFAP2A, or treatment with sumoylation inhibitors induced a basal-to-luminal transition, which was dependent on TFAP2A.
Drosophila Smt3 negatively regulates JNK signaling through sequestering Hipk in the nucleus.
GeneRIF
Jiao et al., Beijing, China. In Development, 2011
although knockdown of the homeodomain-interacting protein kinase (Hipk) suppresses Smt3 depletion-induced activation of JNK, Hipk overexpression synergistically enhances this type of JNK activation
Ubiquitin-proteasome genes as targets for modulation of cisplatin sensitivity in fission yeast.
GeneRIF
Perego et al., Milano, Italy. In Bmc Genomics, 2010
Data show that pmt3 mutants exhibiting hypersensitivity to cisplatin.
Role of the Zn(2+) motif of E1 in SUMO adenylation.
GeneRIF
Chen et al., Duarte, United States. In J Biol Chem, 2010
the Zn(2+) motif of E1 has a role in SUMO adenylation
Cdk1 and SUMO regulate Swe1 stability.
GeneRIF
Brandeis et al., Jerusalem, Israel. In Plos One, 2009
Cdk1 and SUMO (Smt3) regulate Swe1 stability
Genetic and proteomic evidence for roles of Drosophila SUMO in cell cycle control, Ras signaling, and early pattern formation.
GeneRIF
Courey et al., Los Angeles, United States. In Plos One, 2008
SUMO coordinates multiple regulatory processes during oogenesis and early embryogenesis
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