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Acta2 smooth muscle alpha-actin

smooth muscle alpha-actin
contractile protein; required for extracellular matrix remodeling [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: alpha-actin, Actin, CAN, HAD, MUC4
Papers on smooth muscle alpha-actin
Tubular Compressed Collagen Scaffolds for Ureteral Tissue Engineering in a Flow Bioreactor System.
Frey et al., Lausanne, Switzerland. In Tissue Eng Part A, Sep 2015
This was confirmed by their gene expression of smooth muscle alpha-actin, smoothelin, collagen type I and III, elastin, laminin type 1 and 5, cytokeratin 8, and uroplakin 2. In addition, smooth muscle cell alignment predominantly perpendicular to the flow direction was observed, comparable to the cell orientation in native ureteral tissue.
Activation of Transcription Factor GAX and Concomitant Downregulation of IL-1β and ERK1/2 Modulate Vascular Smooth Muscle Cell Phenotype in 3D Fibrous Scaffolds.
Mequanint et al., London, Canada. In Tissue Eng Part A, Sep 2015
This study shows that 3D electrospun fibrous scaffolds regulate human coronary artery smooth muscle cells (HCASMCs) toward a more synthetic phenotype characterized by reduced contractile markers, such as smooth muscle alpha-actin and calponin.
Mutated myocilin and heterozygous Sod2 deficiency act synergistically in a mouse model of open-angle glaucoma.
Tomarev et al., Bethesda, United States. In Hum Mol Genet, Jul 2015
Accumulation of Y437H myocilin in the TM induced endoplasmic reticulum stress and led to a 45% loss of smooth muscle alpha-actin positive cells in the eye drainage structure of 10- to 12-month-old Tg-MYOC(Y437H/+)/Sod2(+/-) mice as compared with wild-type littermates.
Cellular and Extracellular Matrix Basis for Heterogeneity in Mitral Annular Contraction.
Grande-Allen et al., Houston, United States. In Cardiovasc Eng Technol, Jul 2015
RESULTS: Whereas SEPT contained more collagen I and III, LAT demonstrated more collagen and elastin turnover as shown by greater decorin, lysyl oxidase, and matrix metalloprotease (MMP)-13 and smooth muscle alpha-actin (SMaA).
Heterogeneity of Mitral Leaflet Matrix Composition and Turnover Correlates with Regional Leaflet Strain.
Grande-Allen et al., Stanford, United States. In Cardiovasc Eng Technol, Jun 2015
Collagens I and III in SEPT were greater than in LAT, although LAT showed greater collagen turnover (matrix metalloprotease (MMP)-13, lysyl oxidase) and cell activation (smooth muscle alpha-actin, SMaA, and non-muscle myosin, NMM).
Adaptation of a Cell-Based High Content Screening System for the In-Depth Analysis of Celiac Biopsy Tissue.
Dunne et al., Dublin, Ireland. In Methods Mol Biol, 2014
We adapted IN Cell Analyzer 1000's image acquisition and analysis software for the investigation of tissue transglutaminase (tTG) and smooth muscle alpha-actin (SM α-actin) staining in paraffin-embedded duodenal tissue sections from celiac patients and healthy controls.
Nuclear factor-κB mediates the phenotype switching of airway smooth muscle cells in a murine asthma model.
Fan et al., Shenzhen, China. In Int J Clin Exp Pathol, 2014
We found that chronic asthma increased the activation of NF-κB in the primary murine ASM cells with a concomitant marked decrease in the expression of contractile phenotypic marker protein including smooth muscle alpha-actin (α-SMA).
Cardiac development in zebrafish and human embryonic stem cells is inhibited by exposure to tobacco cigarettes and e-cigarettes.
Murry et al., Seattle, United States. In Plos One, 2014
Furthermore, tobacco cigarette-treated samples had delayed onset of beating and showed low levels and aberrant localization of N-cadherin, reduced myofilament content with significantly reduced sarcomere length, and increased expression of the immature cardiac marker smooth muscle alpha-actin.
[The phenotypic switching of vascular smooth muscle cells induced by cholesterol].
Qian et al., Shanghai, China. In Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, 2014
Real-time quantitative PCR and Western blotting were respectively applied to detect the mRNA expressions of smooth muscle alpha-actin (α-SMA), smooth muscle 22 alpha (SM22α) and the protein expressions of SM22α, monocyte chemotactic protein-1 induced protein (MCPIP).
Immunohistochemistry in diagnosis of extranasopharyngeal angiofibroma originating from nasal cavity: case presentation and review of the literature.
Zivić et al., In Acta Medica (hradec Kralove), 2012
The staining was positive for CD34, CD31, factor VIII, vimentin and smooth muscle alpha-actin, and negative for desmin.
Abolishing myofibroblast arrhythmogeneicity by pharmacological ablation of α-smooth muscle actin containing stress fibers.
Rohr et al., Bern, Switzerland. In Circ Res, 2011
The results suggest that alpha-SMA containing stress fibers contribute to myofibroblast arrhythmogeneicity. After ablation of this cytoskeletal component, cells lose their arrhythmic effects on cardiomyocytes.
Significance of α-SMA in myofibroblasts emerging in renal tubulointerstitial fibrosis.
Fujikura et al., Ōita, Japan. In Histol Histopathol, 2011
alpha-SMA expression in renal interstitial fibroblasts, i.e., myofibroblast transdifferentiation, accelerates the contraction of the tubulointerstitial fibrosis tissue via the Ca(2)+-dependent pathway
Leptin and acetaldehyde synergistically promotes αSMA expression in hepatic stellate cells by an interleukin 6-dependent mechanism.
Wang et al., Westmead, Australia. In Alcohol Clin Exp Res, 2011
Leptin potentiates acetaldehyde-induced hepatic stellate cell activation and transdifferentiation as evidenced by increased alpha-smooth muscle actin expression.
Effect of insulin-like growth factors on lung development in a nitrofen-induced CDH rat model.
Taguchi et al., Fukuoka, Japan. In Pediatr Surg Int, 2011
There was a significant increase in the expression of both TTF-1 and T1alpha mRNA in the IGF-2 group, in comparison to the control group after 48 h of culture.
[Role of connective tissue growth factor and α-smooth muscle actin in pulmonary fibrosis among acute paraquat poisoned rats].
Zhou et al., Shanghai, China. In Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi, 2010
CTGF and alpha-SMA could play an important role in the development of pulmonary fibrosis caused by paraquat poisoning.
Chronic pancreatitis: potential future interventions.
Andersson et al., Lund, Sweden. In Scand J Gastroenterol, 2010
During pancreatic injury or inflammation, quiescent stellate cells undergo a phenotypic transformation, characterized by smooth muscle alpha-actin expression and increased synthesis of extracellular matrix proteins.
F2-isoprostanes are not just markers of oxidative stress.
Gardi et al., Siena, Italy. In Free Radic Biol Med, 2008
When hepatic stellate cells from normal liver were cultured up to activation (expression of smooth muscle alpha-actin) and then treated with F(2)-IsoPs in the concentration range found in the in vivo studies (10(-9) to 10(-8) M), a striking increase in DNA synthesis, cell proliferation, and collagen synthesis was observed.
MCAT elements and the TEF-1 family of transcription factors in muscle development and disease.
Yoshida, Charlottesville, United States. In Arterioscler Thromb Vasc Biol, 2008
MCAT elements are located in the promoter-enhancer regions of cardiac, smooth, and skeletal muscle-specific genes including cardiac troponin T, beta-myosin heavy chain, smooth muscle alpha-actin, and skeletal alpha-actin, and play a key role in the regulation of these genes during muscle development and disease.
Mutations in smooth muscle alpha-actin (ACTA2) lead to thoracic aortic aneurysms and dissections.
Milewicz et al., Houston, United States. In Nat Genet, 2007
SMC contractile force requires cyclic interactions between SMC alpha-actin (encoded by ACTA2) and the beta-myosin heavy chain (encoded by MYH11).
Decreased expression of smooth muscle alpha-actin results in decreased contractile function of the mouse bladder.
Kropp et al., Oklahoma City, United States. In J Urol, 2004
PURPOSE: Smooth muscle alpha-actin (SMalphaA) is an important actin isoform for functional contractility in the mouse bladder.
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