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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Spermine oxidase

Smo, Smoothened, polyamine oxidase, spermine oxidase
The product of this gene is the polyamine oxidase. This enzyme potentially represents a new class of catabolic enzymes in the mammalian polyamine metabolic pathway capable of the efficient oxidation of polyamines. More than five transcript variants encoding four active isoenzymes have been identified for this gene, however, not all variants have been fully described. The characterized isoenzymes have distinctive biochemical characteristics and substrate specificities, suggesting the existence of additional levels of complexity in polyamine catabolism. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Gli, Shh, CAN, THP, V1a
Papers on Smo
I only have eye for ewe: the discovery of cyclopamine and development of Hedgehog pathway-targeting drugs.
New
Chen, Stanford, United States. In Nat Prod Rep, Feb 2016
The precise mechanism of cyclopamine action remained enigmatic for 30 years, until this steroid alkaloid was found to be the first specific inhibitor of Hedgehog (Hh) signalling and a direct antagonist of the transmembrane receptor Smoothened (SMO).
Targeting hedgehog signaling pathway in pediatric tumors: in vitro evaluation of SMO and GLI inhibitors.
New
Lanvers-Kaminsky et al., Berlin, Germany. In Cancer Chemother Pharmacol, Feb 2016
PURPOSE: The successful use of SMO inhibitors in tumors with activating mutations in hedgehog signaling raised interests in their exploitation against other malignancies.
Effects of Combined Treatment With Arsenic Trioxide and Itraconazole in Patients With Refractory Metastatic Basal Cell Carcinoma.
New
Colevas et al., Stanford, United States. In Jama Dermatol, Feb 2016
Importance: Tumor resistance is an emerging problem for Smoothened (SMO) inhibitor-treated metastatic basal cell carcinoma (BCC).
Hedgehog signaling pathway: a novel model and molecular mechanisms of signal transduction.
Review
New
Gorojankina, Gif-sur-Yvette, France. In Cell Mol Life Sci, Feb 2016
Here I review published data and present a novel model of vertebrate Hh signaling suggesting that Smoothened (Smo) functions as a G-protein-coupled receptor in cilia.
DYRK1B as therapeutic target in Hedgehog/GLI-dependent cancer cells with Smoothened inhibitor resistance.
New
Aberger et al., Salzburg, Austria. In Oncotarget, Feb 2016
Targeting oncogenic HH/GLI signaling with small molecule inhibitors of the essential pathway effector Smoothened (SMO) has shown remarkable therapeutic effects in patients with advanced and metastatic basal cell carcinoma.
Hedgehog Signaling Regulates the Ciliary Transport of Odorant Receptors in Drosophila.
New
Alenius et al., Linköping, Sweden. In Cell Rep, Feb 2016
Regulation relies on ciliary localization of the Hh signal transducer Smoothened (Smo).
Dopaminergic Neurons and Brain Reward Pathways: From Neurogenesis to Circuit Assembly.
Review
New
Huang et al., San Francisco, United States. In Am J Pathol, Jan 2016
This review provides a comprehensive discussion on how Wnt/β-catenin and sonic hedgehog-Smoothened signaling mechanisms control the specification and expansion of DA progenitors and the differentiation of DA neurons.
Oral therapy for nonmelanoma skin cancer in patients with advanced disease and large tumor burden: a review of the literature with focus on a new generation of targeted therapies.
Review
New
Cherpelis et al., Tampa, United States. In Int J Dermatol, Dec 2015
Oral Smoothened (Smo) inhibitors Vismodegib, Sonidegib, and Taladegib have shown to be effective in several trials.
Vismodegib Exerts Targeted Efficacy Against Recurrent Sonic Hedgehog-Subgroup Medulloblastoma: Results From Phase II Pediatric Brain Tumor Consortium Studies PBTC-025B and PBTC-032.
New
Impact
Gajjar et al., Memphis, United States. In J Clin Oncol, Sep 2015
PURPOSE: Two phase II studies assessed the efficacy of vismodegib, a sonic hedgehog (SHH) pathway inhibitor that binds smoothened (SMO), in pediatric and adult recurrent medulloblastoma (MB).
Genomic analysis of smoothened inhibitor resistance in basal cell carcinoma.
New
Impact
de Sauvage et al., San Francisco, United States. In Cancer Cell, Apr 2015
Smoothened (SMO) inhibitors are under clinical investigation for the treatment of several cancers.
Smoothened variants explain the majority of drug resistance in basal cell carcinoma.
New
Impact
Tang et al., Stanford, United States. In Cancer Cell, Apr 2015
Advanced basal cell carcinomas (BCCs) frequently acquire resistance to Smoothened (SMO) inhibitors through unknown mechanisms.
Vismodegib resistance in basal cell carcinoma: not a smooth fit.
New
Impact
Cotsarelis et al., Philadelphia, United States. In Cancer Cell, Apr 2015
In this issue of Cancer Cell, two complementary papers by Atwood and colleagues and Sharpe and colleagues show that basal cell carcinomas resistant to the Smoothened (SMO) inhibitor vismodegib frequently harbor SMO mutations that limit drug binding, with mutations at some sites also increasing basal SMO activity.
Aberrant GLI1 Activation in DNA Damage Response, Carcinogenesis and Chemoresistance.
Review
Athar et al., Mobile, United States. In Cancers (basel), 2014
The canonical hedgehog (HH) pathway is a multicomponent signaling cascade (HH, protein patched homolog 1 (PTCH1), smoothened (SMO)) that plays a pivotal role during embryonic development through activation of downstream effector molecules, namely glioma-associated oncogene homolog 1 (GLI1), GLI2 and GLI3.
Ameloblastoma: A Review of Recent Molecular Pathogenetic Discoveries.
Review
Betz et al., Ann Arbor, United States. In Biomark Cancer, 2014
Some degree of controversy exists regarding the role of mutations affecting the sonic hedgehog (SHH) pathway, specifically Smoothened (SMO), which have been postulated to serve as either an alternative pathogenetic mechanism or secondary mutations.
Epigenetic targeting of Hedgehog pathway transcriptional output through BET bromodomain inhibition.
Impact
Cho et al., Stanford, United States. In Nat Med, 2014
Hedgehog signaling drives oncogenesis in several cancers, and strategies targeting this pathway have been developed, most notably through inhibition of Smoothened (SMO).
Small molecule inhibitors of Smoothened ciliary localization and ciliogenesis.
GeneRIF
Reiter et al., San Francisco, United States. In Proc Natl Acad Sci U S A, 2012
different pools of Smo move into cilia through distinct mechanisms
Inhibition of hedgehog signalling prevents experimental fibrosis and induces regression of established fibrosis.
GeneRIF
Distler et al., Erlangen, Germany. In Ann Rheum Dis, 2012
Inhibition of hedgehog signalling exerted potent antifibrotic effects in preclinical models of SSc in both preventive and therapeutic settings.
The immunoexpression of Shh, Smo and Gli2 in Helicobacter pylori positive and negative gastric biopsies.
GeneRIF
Danilewicz et al., Łódź, Poland. In Pol J Pathol, 2012
The immunoexpression of Shh, Smo and Gli2 proteins was lower in Helicobacter pylori-positive group compared to Helicobacter pylori-negative group
USP8 promotes smoothened signaling by preventing its ubiquitination and changing its subcellular localization.
GeneRIF
Jia et al., Lexington, United States. In Plos Biol, 2012
USP8 is a positive regulator in Hh signaling by down-regulating Smo ubiquitination and thereby mediating Smo intracellular trafficking.
Hedgehog-regulated ubiquitination controls smoothened trafficking and cell surface expression in Drosophila.
GeneRIF
Jiang et al., Dallas, United States. In Plos Biol, 2012
Hh-induced phosphorylation promotes Smo cell surface accumulation by inhibiting its ubiquitination, which contributes to Hh pathway activation.
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