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Small nuclear ribonucleoprotein polypeptide G

SMG, Smaug
Sterile alpha motifs (SAMs) in proteins such as SAMD4A are part of an RNA-binding domain that functions as a posttranscriptional regulator by binding to an RNA sequence motif known as the Smaug recognition element, which was named after the Drosophila Smaug protein (Baez and Boccaccio, 2005 [PubMed 16221671]).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, V1a, ACID, AGE
Papers on SMG
Connexin 43 Is Necessary for Salivary Gland Branching Morphogenesis and FGF10-induced ERK1/2 Phosphorylation.
Fukumoto et al., Fukuoka, Japan. In J Biol Chem, Feb 2016
In ex vivo organ cultures of SMGs, addition of the gap junctional inhibitors 18α-glycyrrhetinic acid (18α-GA) and oleamide inhibited SMG branching morphogenesis, suggesting that gap junctional communication contributes to salivary gland development.
Bimodal bilingualism as multisensory training?: Evidence for improved audiovisual speech perception after sign language exposure.
Newman et al., United States. In Brain Res, Jan 2016
Results indicated increased activation in the supramarginal gyrus (SMG) after sign language exposure, which suggests concomitant increased phonological processing of speech.
Heterogeneous and nonlinear development of human posterior parietal cortex function.
Menon et al., Stanford, United States. In Neuroimage, Jan 2016
Here we challenge this limited view, and investigate spatially heterogeneous and nonlinear neurodevelopmental profiles between childhood, adolescence, and young adulthood, focusing on three cytoarchitectonically distinct posterior parietal cortex (PPC) regions implicated in numerical problem solving: intraparietal sulcus (IPS), angular gyrus (AG), and supramarginal gyrus (SMG).
Contribution of dysregulated serum magnesium to mortality in hemodialysis patients with secondary hyperparathyroidism: a 3-year cohort study.
Fukuhara et al., Fukushima, Japan. In Clin Kidney J, Dec 2015
Baseline serum magnesium (sMg) values were categorized into quintiles (≤2.3, >2.3-2.5, >2.5-2.7,
PIKKs--the solenoid nest where partners and kinases meet.
Williams et al., Cambridge, United Kingdom. In Curr Opin Struct Biol, 2014
The recent structure of a truncated mTOR in a complex with mLST8 has provided a basic framework for understanding all of the phosphoinositide 3-kinase (PI3K)-related kinases (PIKKs): mTOR, ATM, ATR, SMG-1, TRRAP and DNA-PK.
Regulation of the Target of Rapamycin and Other Phosphatidylinositol 3-Kinase-Related Kinases by Membrane Targeting.
Dames et al., Garching bei München, Germany. In Membranes (basel), 2014
In humans six family members are known to date, namely mammalian/mechanistic target of rapamycin (mTOR), ataxia-telangiectasia mutated (ATM), ataxia- and Rad3-related (ATR), DNA-dependent protein kinase catalytic subunit (DNA-PKcs), suppressor of morphogenesis in genitalia-1 (SMG-1), and transformation/transcription domain-associated protein (TRRAP).
The Right Supramarginal Gyrus Is Important for Proprioception in Healthy and Stroke-Affected Participants: A Functional MRI Study.
Carey et al., Melbourne, Australia. In Front Neurol, 2014
We found proprioception-related brain activation in high-order sensorimotor cortices in healthy participants especially in the supramarginal gyrus (SMG LWP z = 4.51, RWP z = 4.24) and the dorsal premotor cortex (PMd LWP z = 4.10, RWP z = 3.93).
Synaptic control of local translation: the plot thickens with new characters.
Boccaccio et al., Buenos Aires, Argentina. In Cell Mol Life Sci, 2014
The mRNA repressors Smaug, Nanos, and Pumilio define a novel pathway for local translational control that affects dendritic branching and spines in both flies and mammals.
Role of SMG-1-mediated Upf1 phosphorylation in mammalian nonsense-mediated mRNA decay.
Yamashita, Yokohama, Japan. In Genes Cells, 2013
SMG-1, a member of the PIKK (phosphoinositide 3-kinase-related kinase) family, plays a critical role in the mRNA quality control system known as nonsense-mediated mRNA decay (NMD).
Less is more: strategies to remove marker genes from transgenic plants.
Stewart et al., Knoxville, United States. In Bmc Biotechnol, 2012
Their use also prevents the re-use of the same SMG when a second transformation scheme is needed to be performed on the transgenic host.
Smaug1 mRNA-silencing foci respond to NMDA and modulate synapse formation.
Boccaccio et al., Buenos Aires, Argentina. In J Cell Biol, 2012
The Smaug1 is expressed during synaptogenesis, and Smaug1 knockdown affected the number and size of synapses, and also provoked an impaired response to repetitive depolarizing stimuli, as indicated by a reduced induction of Arc/Arg3.1.
Structure of the spliceosomal U4 snRNP core domain and its implication for snRNP biogenesis.
Li et al., Cambridge, United Kingdom. In Nature, 2011
Four of the five major components of the spliceosome, U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), contain seven Sm proteins (SmB/B', SmD1, SmD2, SmD3, SmE, SmF and SmG) in common.
Smaug assembles an ATP-dependent stable complex repressing nanos mRNA translation at multiple levels.
Wahle et al., Halle, Germany. In Embo J, 2011
This paper reports that the Smaug recognition elements in the 3' UTR of nanos (nos) mRNA govern the time- and ATP-dependent assembly of an exceedingly stable repressed ribonucleoprotein particle (RNP) in embryo extract.
Maternal mRNA deadenylation and decay by the piRNA pathway in the early Drosophila embryo.
Simonelig et al., Montpellier, France. In Nature, 2010
In Drosophila, maternal mRNA degradation depends on the RNA-binding protein Smaug and the deadenylase CCR4, as well as the zygotic expression of a microRNA cluster.
Myocardin-dependent activation of the CArG box-rich smooth muscle gamma-actin gene: preferential utilization of a single CArG element through functional association with the NKX3.1 homeodomain protein.
Miano et al., Rochester, United States. In J Biol Chem, 2009
MYOCD can discriminate among several juxtaposed CArG elements, presumably through its novel partnership with NKX3.1, to optimally transactivate the human ACTG2 promoter
An essential role for the RNA-binding protein Smaug during the Drosophila maternal-to-zygotic transition.
Theurkauf et al., Worcester, United States. In Development, 2009
Smaug accumulation thus coordinates progression through the maternal-to-zygotic transition
The zinc-finger protein Zelda is a key activator of the early zygotic genome in Drosophila.
Rushlow et al., East New York, United States. In Nature, 2008
The recent findings that microRNAs and Smaug mediate maternal transcript degradation have shed new light on this aspect of the problem.
Drosophila maternal Hsp83 mRNA destabilization is directed by multiple SMAUG recognition elements in the open reading frame.
Lipshitz et al., Toronto, Canada. In Mol Cell Biol, 2008
Data show that Smaug can recruit the CCR4-NOT deadenylase to trigger Hsp83 mRNA degradation despite the fact that it is being translated.
The multiple lives of NMD factors: balancing roles in gene and genome regulation.
Maquat et al., Rochester, United States. In Nat Rev Genet, 2008
Recent studies have clarified that UPF and SMG proteins, which were originally discovered to function in NMD, also have roles in other pathways, including specialized pathways of mRNA decay, DNA synthesis and cell-cycle progression, and the maintenance of telomeres.
Telomeric repeat containing RNA and RNA surveillance factors at mammalian chromosome ends.
Lingner et al., China. In Science, 2007
We also show that suppressors with morphogenetic defects in genitalia (SMG) proteins, which are effectors of nonsense-mediated messenger RNA decay, are enriched at telomeres in vivo, negatively regulate TERRA association with chromatin, and protect chromosome ends from telomere loss.
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