gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Smg-8 homolog, nonsense mediated mRNA decay factor

SMG-8
Top mentioned proteins: LIP, SMG, caspase-3, UPF1, STEP
Papers on SMG-8
A network of SMG-8, SMG-9 and SMG-1 C-terminal insertion domain regulates UPF1 substrate recruitment and phosphorylation.
New
Schaffitzel et al., Grenoble, France. In Nucleic Acids Res, Oct 2015
Phosphorylation of the essential NMD effector UPF1 by the phosphoinositide-3-kinase-like kinase (PIKK) SMG-1 is a key step in NMD and occurs when SMG-1, its two regulatory factors SMG-8 and SMG-9, and UPF1 form a complex at a terminating ribosome.
Inhibition of SMG-8, a subunit of SMG-1 kinase, ameliorates nonsense-mediated mRNA decay-exacerbated mutant phenotypes without cytotoxicity.
Ohno et al., Minamata, Japan. In Proc Natl Acad Sci U S A, 2013
Of the 15 NMD factors tested, knockdown of SMG-8 produced the best effect for restoring defective mRNA and protein levels without affecting cell growth, cell-cycle progression, or endoplasmic reticulum stress.
Genetic characterization of smg-8 mutants reveals no role in C. elegans nonsense mediated decay.
Mango et al., Cambridge, United States. In Plos One, 2011
In mammals, SMG-8 has been implicated in the NMD pathway, in part by its association with SMG-1 kinase.
Role of a tyrosine phosphorylation of SMG-9 in binding of SMG-9 to IQGAP and the NMD complex.
Konishi et al., Shōbara, Japan. In Biochem Biophys Res Commun, 2011
SMG-9 is a component of the NMD complex, a heterotetramer that also includes SMG-1 and SMG-8 in the complex.
The nonsense-mediated mRNA decay SMG-1 kinase is regulated by large-scale conformational changes controlled by SMG-8.
GeneRIF
Llorca et al., Madrid, Spain. In Genes Dev, 2011
large-scale conformational changes induced by SMG-8 after SMG-9-mediated recruitment tune SMG-1 kinase activity to modulate nonsense-mediated mRNA decay
Characterization of SMG-9, an essential component of the nonsense-mediated mRNA decay SMG1C complex.
Llorca et al., Madrid, Spain. In Nucleic Acids Res, 2011
SMG-9 is part of a protein kinase complex, SMG1C, which consists of the SMG-1 kinase, SMG-8 and SMG-9.
SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay.
Ohno et al., Yokohama, Japan. In Genes Dev, 2009
We identified SMG-8 and SMG-9 as novel subunits of the SMG-1 complex.
share on facebooktweetadd +1mail to friends