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Small nuclear ribonucleoprotein D2 polypeptide 16.5kDa

sMD-2, NRPD1a, SNRPD1
The protein encoded by this gene belongs to the small nuclear ribonucleoprotein core protein family. It is required for pre-mRNA splicing and small nuclear ribonucleoprotein biogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009] (from NCBI)
Top mentioned proteins: SmD1, MD-2, TLR4, POLYMERASE, CAN
Papers on sMD-2
Amniotic Fluid Soluble Myeloid Differentiation-2 (sMD-2) as Regulator of Intra-amniotic Inflammation in Infection-induced Preterm Birth.
New
Buhimschi et al., Columbus, United States. In Am J Reprod Immunol, Jun 2015
PROBLEM: TLR4 mediates host responses to pathogens through a mechanism that involves protein myeloid differentiation-2 (MD-2) and its soluble form sMD-2.
Transient down-regulation of the RNA silencing machinery increases efficiency of Agrobacterium-mediated transformation of Arabidopsis.
Kovalchuk et al., Lethbridge, Canada. In Plant Biotechnol J, 2014
Using mutants compromised in either the transcriptional or post-transcriptional gene-silencing pathways, two inhibitors of stable transformation were revealed-AGO2 and NRPD1a.
Fam118B, a newly identified component of Cajal bodies, is required for Cajal body formation, snRNP biogenesis and cell viability.
Chen et al., Guangzhou, China. In J Cell Sci, 2014
Overexpression of Fam118B changes the canonical morphology of Cajal bodies, whereas depletion of Fam118B disrupts the localization of components of Cajal bodies, including coilin, the survival of motor neuron protein (SMN) and the Sm protein D1 (SmD1, also known as SNRPD1).
The SMN Tudor SIM-like domain is key to SmD1 and coilin interactions and to Cajal body biogenesis.
Berciano et al., Santander, Spain. In J Cell Sci, 2014
The expression of SIM-like mutant constructs abolishes the interaction of SMN with the spliceosomal SmD1 (also known as SNRPD1), severely decreases SMN-coilin interaction and prevents CB assembly.
Radioiodination of an endotoxin·MD-2 complex generates a novel sensitive, high-affinity ligand for TLR4.
Gioannini et al., Iowa City, United States. In Innate Immun, 2013
Radioiodinated LOS·MD-2 generated a reagent with an estimated 1:1 molar ratio of [(125)I] to sMD-2 with 20-fold higher specific radioactivity and TLR4-activating properties comparable to metabolically-labeled LOS·MD-2.
Targeting the deregulated spliceosome core machinery in cancer cells triggers mTOR blockade and autophagy.
André et al., Paris, France. In Cancer Res, 2013
siRNA-mediated depletion of SmE (SNRPE) or SmD1 (SNRPD1) led to a marked reduction of cell viability in breast, lung, and melanoma cancer cell lines, whereas it had little effect on the survival of the nonmalignant MCF-10A breast epithelial cells.
Regulation of the S-locus receptor kinase and self-incompatibility in Arabidopsis thaliana.
Nasrallah et al., Ithaca, United States. In G3 (bethesda), 2013
This mutation disrupts NRPD1a, a gene that encodes a plant-specific nuclear RNA polymerase required for genomic methylation and production of some types of silencing RNAs.
QTL analysis of high thermotolerance with superior and downgraded parental yeast strains reveals new minor QTLs and converges on novel causative alleles involved in RNA processing.
Thevelein et al., Leuven, Belgium. In Plos Genet, 2012
We validated the two most-strongly linked new QTLs by identifying NCS2 and SMD2 as causative genes linked to the superior downgraded parent and we found an allele-specific epistatic interaction between PRP42 and SMD2.
Trypsin inhibits lipopolysaccharide signaling in macrophages via toll-like receptor 4 accessory molecules.
Sato et al., Yamaguchi, Japan. In Life Sci, 2012
To clarify the effect of trypsin on LPS receptors, we also investigated the expression of toll-like receptor 4 (TLR4), soluble MD-2 (sMD-2), membrane-bound MD-2 (mMD-2), soluble CD14 (sCD14), and membrane-bound CD14 (mCD14).
Time-lapse imaging of neuroblastoma cells to determine cell fate upon gene knockdown.
König et al., Heidelberg, Germany. In Plos One, 2011
We identified six genes (DLGAP5, DSCC1, SMO, SNRPD1, SSBP1, and UBE2C) with a vital role in mitosis and these are promising therapeutic targets for neuroblastoma.
SHH1, a homeodomain protein required for DNA methylation, as well as RDR2, RDM4, and chromatin remodeling factors, associate with RNA polymerase IV.
GeneRIF
Jacobsen et al., Los Angeles, United States. In Plos Genet, 2011
Data show that SHH1(AT1G15215), RDR2, CLASSY1, and RDM4 were co-purified with NRPD1(At1g63020), the largest subunit of Pol-IV.
Structure of the spliceosomal U4 snRNP core domain and its implication for snRNP biogenesis.
Impact
Li et al., Cambridge, United Kingdom. In Nature, 2011
Four of the five major components of the spliceosome, U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), contain seven Sm proteins (SmB/B', SmD1, SmD2, SmD3, SmE, SmF and SmG) in common.
Maternal control of Pol IV-dependent siRNAs in Arabidopsis endosperm.
GeneRIF
Mosher, Cambridge, United Kingdom. In New Phytol, 2010
Pol IV-dependent (p4-)siRNAs are initially expressed in the maternal gametophyte and uniparentally expressed from maternal chromosomes in developing endosperm.
Intergenic transcription by RNA polymerase II coordinates Pol IV and Pol V in siRNA-directed transcriptional gene silencing in Arabidopsis.
GeneRIF
Chen et al., Riverside, United States. In Genes Dev, 2010
Arabidopsis Pol II is indispensable for endogenous siRNA-mediated transcriptional gene silencing (TGS) at intergenic low-copy-number loci, despite the presence of two other polymerases-Pol IV and Pol V-that specialize in TGS through siRNAs
NRPD1a and NRPD1b are required to maintain post-transcriptional RNA silencing and RNA-directed DNA methylation in Arabidopsis.
GeneRIF
Jones et al., York, United Kingdom. In Plant J, 2008
Mutants defective for the NRPD1a and NRPD1b alternative largest subunits of polymerase IV were tested for their ability to undergo RNA silencing and mantenance of transcription and post-transcriptional silencing
Nuclear gene silencing directs reception of long-distance mRNA silencing in Arabidopsis.
GeneRIF
Carroll et al., Australia. In Proc Natl Acad Sci U S A, 2007
NRPD1a is required for reception of long-distance mRNA silencing.
Intra- and intercellular RNA interference in Arabidopsis thaliana requires components of the microRNA and heterochromatic silencing pathways.
Impact
Voinnet et al., Strasbourg, France. In Nat Genet, 2007
We found that SMD1 and SMD2, required for intercellular but not intracellular RNAi, are allelic to RDR2 and NRPD1a, respectively, previously implicated in siRNA-directed heterochromatin formation through the action of DCL3 and AGO4.
DICER-LIKE 4 is required for RNA interference and produces the 21-nucleotide small interfering RNA component of the plant cell-to-cell silencing signal.
Impact
Voinnet et al., Strasbourg, France. In Nat Genet, 2005
At least three SILENCING MOVEMENT DEFICIENT genes (SMD1, SMD2 and SMD3) are required for trafficking, the extent of which correlates with siRNA levels in the veins.
Atypical RNA polymerase subunits required for RNA-directed DNA methylation.
Impact
Matzke et al., Vienna, Austria. In Nat Genet, 2005
DRD3 is a functionally diversified homolog of NRPD1a or SDE4, identified in a separate screen for mutants defective in post-transcriptional gene silencing.
RNA polymerase IV directs silencing of endogenous DNA.
Impact
GeneRIF
Baulcombe et al., Norwich, United Kingdom. In Science, 2005
results show that RNA polymerase IV (Pol IV, subunits NRPD1a and NRPD2) silences certain transposons and repetitive DNA in a short interfering RNA pathway involving RNA-dependent RNA polymerase 2 and Dicer-like 3(DCL3) [NRPD1a]
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