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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

SMC5 Smc5p

Smc5, Spr18
Top mentioned proteins: MUC4, RAD18, Smt3, SMC1, Nse1
Papers on Smc5
Global Reprogramming of Host SUMOylation during Influenza Virus Infection.
New
Hale et al., Glasgow, United Kingdom. In Cell Rep, Dec 2015
Depletion screening identified ten virus-induced SUMO targets as potential antiviral factors, including C18orf25 and the SMC5/6 and PAF1 complexes.
NSMCE2 suppresses cancer and aging in mice independently of its SUMO ligase activity.
New
Fernandez-Capetillo et al., Madrid, Spain. In Embo J, Dec 2015
The SMC5/6 complex is the least understood of SMC complexes.
Integrated genomic and transcriptomic analysis of human brain metastases identifies alterations of potential clinical significance.
New
Lakhani et al., Australia. In J Pathol, Nov 2015
(a) Identification of novel candidates with possible roles in BM development, including the significantly mutated genes DSC2, ST7, PIK3R1 and SMC5, and the DNA repair, ERBB-HER signalling, axon guidance and protein kinase-A signalling pathways.
Chromatin association of the SMC5/6 complex is dependent on binding of its NSE3 subunit to DNA.
New
Palecek et al., Brno, Czech Republic. In Nucleic Acids Res, Nov 2015
UNASSIGNED: SMC5/6 is a highly conserved protein complex related to cohesin and condensin, which are the key components of higher-order chromatin structures.
Repair of DNA Damage Induced by the Cytidine Analog Zebularine Requires ATR and ATM in Arabidopsis.
New
Pecinka et al., Köln, Germany. In Plant Cell, Jun 2015
The repair requires a functional STRUCTURAL MAINTENANCE OF CHROMOSOMES5 (SMC5)-SMC6 complex and is accomplished predominantly by synthesis-dependent strand-annealing homologous recombination.
DNA repair. Proteomics reveals dynamic assembly of repair complexes during bypass of DNA cross-links.
New
Impact
Mann et al., Martinsried, Germany. In Science, Jun 2015
Among numerous prospective DNA repair factors, we identified SLF1 and SLF2, which form a complex with RAD18 and together define a pathway that suppresses genome instability by recruiting the SMC5/6 cohesion complex to DNA lesions.
The melanoma-associated antigen 1 (MAGEA1) protein stimulates the E3 ubiquitin-ligase activity of TRIM31 within a TRIM31-MAGEA1-NSE4 complex.
Palecek et al., Brno, Czech Republic. In Cell Cycle, 2014
NSE3, together with its partner proteins NSE1 and NSE4 form a tight subcomplex of the structural maintenance of chromosomes SMC5-6 complex.
AtMMS21 regulates DNA damage response and homologous recombination repair in Arabidopsis.
Yang et al., Guangzhou, China. In Dna Repair (amst), 2014
Here we demonstrated the molecular function of AtMMS21, a component of SMC5/6 complex, in plant DNA damage response.
Hypomorphism in human NSMCE2 linked to primordial dwarfism and insulin resistance.
Semple et al., In J Clin Invest, 2014
Two the three known SMC complexes, cohesin and condensin, are important for sister chromatid cohesion and condensation, respectively; however, the function of the third complex, SMC5-6, which includes the E3 SUMO-ligase NSMCE2 (also widely known as MMS21) is less clear.
The SMC5/6 complex is involved in crucial processes during human spermatogenesis.
Hamer et al., Amsterdam, Netherlands. In Biol Reprod, 2014
Chromatin structure and function are in large part determined by the structural maintenance of chromosomes (SMC) protein complexes, of which SMC5/6 recently has been shown to be involved in both spermatogonial differentiation and meiosis during mouse spermatogenesis.
DNA-binding properties of Smc6, a core component of the Smc5-6 DNA repair complex.
GeneRIF
D'Amours et al., Montréal, Canada. In Biochem Biophys Res Commun, 2012
Smc6 contributes to DNA repair in vivo by targeting the Smc5-6 complex to single-stranded DNA substrates created during the processes of homologous recombination and/or DNA replication.
Nse1-dependent recruitment of Smc5/6 to lesion-containing loci contributes to the repair defects of mutant complexes.
GeneRIF
O'Connell et al., New York City, United States. In Mol Biol Cell, 2011
Smc5 is a required for homologous recombination in S. pombe.
The Nse2/Mms21 SUMO ligase of the Smc5/6 complex in the maintenance of genome stability.
GeneRIF
Morrison et al., Galway, Ireland. In Febs Lett, 2011
Studies indicate that Nse1 may function as a ubiquitin ligase, and is targeted to chromatin through its interaction with the Smc5/6 complex.
A touching moment for Smc5/6: from ssDNA binding to repair.
GeneRIF
Smolka et al., Ithaca, United States. In Cell Cycle, 2011
Smc5/Smc6 complex binds single-stranded DNA and participates in DNA replication and repair.
Interactions between the Nse3 and Nse4 components of the SMC5-6 complex identify evolutionarily conserved interactions between MAGE and EID Families.
GeneRIF
Palecek et al., Brighton, United Kingdom. In Plos One, 2010
In an examination of the evolutionary conservation of the Nse3-Nse4 interactions, we find that several MAGE proteins can interact with at least one of the NSE4/EID proteins.
The Yin and Yang of the MMS21-SMC5/6 SUMO ligase complex in homologous recombination.
Review
Potts, Dallas, United States. In Dna Repair (amst), 2009
MMS21/NSE2 is part of the SMC5/6 complex, which has been shown to facilitate DSB repair, collapsed replication fork restart, and telomere elongation by HR.
The unnamed complex: what do we know about Smc5-Smc6?
Review
Aragón et al., London, United Kingdom. In Chromosome Res, 2008
The structural maintenance of chromosome (SMC) proteins constitute the cores of three protein complexes involved in chromosome metabolism; cohesin, condensin and the Smc5-Smc6 complex.
Anaphase onset before complete DNA replication with intact checkpoint responses.
Impact
Aragón et al., London, United Kingdom. In Science, 2007
Here, we show that in yeast smc5-smc6 mutants, which are related to cohesin and condensin, replication is delayed, most significantly at natural replication-impeding loci like the ribosomal DNA gene cluster.
Dynamic molecular linkers of the genome: the first decade of SMC proteins.
Review
Hirano et al., Madrid, Spain. In Genes Dev, 2005
Another complex containing SMC5 and SMC6 is implicated in DNA repair and checkpoint responses.
SMC5 and SMC6 genes are required for the segregation of repetitive chromosome regions.
Impact
GeneRIF
Aragón et al., London, United Kingdom. In Nat Cell Biol, 2005
The lethality of SMC5 mutations is suppressed by the rad52 mutation.
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