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BTG3 associated nuclear protein

SMAR1, BANP
This gene encodes a protein that binds to matrix attachment regions. The protein forms a complex with p53 and negatively regulates p53 transcription, and functions as a tumor suppressor and cell cycle regulator. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010] (from NCBI)
Top mentioned proteins: p53, CAN, V1a, CYP3A4, Histone
Papers on SMAR1
Nuclear matrix protein SMAR1 control regulatory T-cell fate during inflammatory bowel disease (IBD).
New
Chattopadhyay et al., In Mucosal Immunol, Nov 2015
We show that SMAR1, a known transcription factor and tumor suppressor, is directly involved in maintaining Treg cell fate decision.
Nuclear matrix binding protein SMAR1 regulates T-cell differentiation and allergic airway disease.
New
Chattopadhyay et al., Pune, India. In Mucosal Immunol, Nov 2015
Here we report an essential role of the matrix attachment region (MAR)-binding protein SMAR1 in regulating immune response during allergic airway disease.
BEND3 mediates transcriptional repression and heterochromatin organization.
New
Prasanth et al., Urbana, United States. In Transcription, Nov 2015
We have recently demonstrated that BEND3 (BANP, E5R and Nac1 domain) protein represses rDNA transcription by stabilizing a NoRC component.
Regulation of T cell lineage commitment by SMAR1 during inflammatory & autoimmune diseases.
New
Chattopadhyay et al., Pune, India. In Indian J Med Res, Oct 2015
This study was aimed to understand the role of matrix associated region (MAR) binding protein SMAR1 (scaffold/matrix attachment region binding protein 1) in T cell differentiation during inflammatory and autoimmune condition using SMAR1 transgenic mice as model.
MAR binding protein SMAR1 favors IL-10 mediated regulatory T cell function in acute colitis.
New
Chattopadhyay et al., Pune, India. In Biochem Biophys Res Commun, Sep 2015
Here we have shown that a known nuclear matrix binding protein SMAR1 is selectively expressed more in colonic Treg cells and is required for their ability to accumulate at inflammatory site and to sustain high levels of Foxp3 and IL-10 expression during acute colitis.
BEND3 represses rDNA transcription by stabilizing a NoRC component via USP21 deubiquitinase.
New
Prasanth et al., Urbana, United States. In Proc Natl Acad Sci U S A, Aug 2015
We demonstrate in mammalian cells that BANP, E5R, and Nac1 (BEN) domain 3 (BEND3), a quadruple BEN domain-containing protein, localizes in nucleoli and binds to ribosomal RNA gene promoters to help repress rRNA genes.
Reversible induction of translational isoforms of p53 in glucose deprivation.
New
Das et al., Bengaluru, India. In Cell Death Differ, Jul 2015
Surprisingly, we found scaffold/matrix attachment region-binding protein 1 (SMAR1), a predominantly nuclear protein is abundant in the cytoplasm under glucose deprivation.
Nuclear matrix-associated protein SMAR1 regulates alternative splicing via HDAC6-mediated deacetylation of Sam68.
New
Chattopadhyay et al., Pune, India. In Proc Natl Acad Sci U S A, Jul 2015
locus in breast cancer cells, wherein the human homolog of SMAR1 (BANP) has been mapped, enhances Sam68 acetylation and CD44 variant exon inclusion.
Evaluating the Association between Keratoconus and Reported Genetic Loci in a Han Chinese Population.
New
Wang et al., Qingdao, China. In Ophthalmic Genet, Jun 2015
SNPs rs4954218 (Near RAB3GAP1 (5')), rs4894535 (FNDC3B), rs2956540 (LOX), rs3735520 (Near HGF (5')), rs1324183 (MPDZ-NF1B), rs1536482 (RXRA-COL5A1), rs7044529 (COL5A1), rs2721051 (Near FOXO1 (3')), rs9938149 (BANP-ZNF469) and rs6050307 (VSX1) were assessed for their association with KC.
Common and distinct DNA-binding and regulatory activities of the BEN-solo transcription factor family.
Lai et al., New York City, United States. In Genes Dev, 2015
Recently, the BEN (BANP, E5R, and NAC1) domain was recognized as a new class of conserved DNA-binding domain.
Differential Ratios of Omega Fatty Acids (AA/EPA+DHA) Modulate Growth, Lipid Peroxidation and Expression of Tumor Regulatory MARBPs in Breast Cancer Cell Lines MCF7 and MDA-MB-231.
Kaul-Ghanekar et al., Pune, India. In Plos One, 2014
Interestingly, compared to higher n6/n3 FA ratios, lower ratios increased the expression of tumor suppressor MARBP, SMAR1 and decreased the expression of tumor activator Cux/CDP in both breast cancer and non-cancerous, MCF10A cells.
Overexpression of SMAR1 Enhances Radiosensitivity in Human Breast Cancer Cell Line MCF7 via Activation of p53 Signaling Pathway.
Pan et al., Bengbu, China. In Oncol Res, 2014
This study sought to investigate the effect of overexpression of SMAR1 (scaffold/matrix-associated region-binding protein 1) on cell radiosensitivity in breast cancer, as well as elucidate its regulatory mechanism.
SMAR1 coordinates HDAC6-induced deacetylation of Ku70 and dictates cell fate upon irradiation.
Chattopadhyay et al., Pune, India. In Cell Death Dis, 2013
Here, we demonstrate that nuclear matrix-associated protein scaffold/matrix-associated region-binding protein 1 (SMAR1) is a novel interacting partner of Ku70 and coordinates with HDAC6 to maintain Ku70 in a deacetylated state.
Identification of novel T cell factor 4 (TCF-4) binding sites on the HIV long terminal repeat which associate with TCF-4, β-catenin, and SMAR1 to repress HIV transcription.
GeneRIF
Al-Harthi et al., Chicago, United States. In J Virol, 2012
TCF-4, beta-catenin, and SMAR1 tether at the -143-nucleotide site on the HIV LTR to inhibit HIV promoter activity.
Chromatin remodelling protein SMAR1 inhibits p53 dependent transactivation by regulating acetyl transferase p300.
GeneRIF
Chattopadhyay et al., Pune, India. In Int J Biochem Cell Biol, 2012
Results indicate that SMAR1 is an important player in p300-p53 regulated DNA damage signalling pathway and can exert its effect on apoptosis in a transcription independent manner.
Gene regulation by SMAR1: Role in cellular homeostasis and cancer.
Review
GeneRIF
Chattopadhyay et al., Pune, India. In Biochim Biophys Acta, 2011
multiple roles of nuclear matrix associated protein SMAR1 in regulating various cellular target genes involved in cell growth, apoptosis and tumorigenesis.(REVIEW)
Identification and validation of novel C/EBPbeta-regulated genes in preadipocyte proliferation.
GeneRIF
Huang et al., Shanghai, China. In Chin Med J (engl), 2010
C/EBPbeta may regulate preadipocyte proliferation through activation of banp and trim35.
Heat-shock protein 70 binds to a novel sequence in 5' UTR of tumor suppressor SMAR1 and regulates its mRNA stability upon Prostaglandin A2 treatment.
GeneRIF
Chattopadhyay et al., Pune, India. In Febs Lett, 2010
report Prostaglandin A2 (PGA2) induced binding of HSP70 to a novel site on phi1 SMAR1 5' UTR which stabilizes the wild type transcript and leads to subsequent increase in SMAR1 protein levels.
Receptor sites for atrial natriuretic factors in brain and associated structures: an overview.
Review
Quirion, Québec, Canada. In Cell Mol Neurobiol, 1989
These brain ANF sites possibly are of the B-ANP subtype.
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