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SMAD family member 7

The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010] (from NCBI)
Top mentioned proteins: Smad2, Smad3, TGF-beta, V1a, CAN
Papers using Smad7 antibodies
Anti-inflammatory properties of phenolic compounds and crude extract from Porphyra dentata
Chiang Hsiu-Mei et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 2009
... (Thr 180/Tyr 182)-R, p-JNK (Thr 183/Tyr 185), p-ERK 1/2 (Thr 202/Tyr 204), Smad 3 (38Q), and Smad 7 (H-79) were purchased from Santa Cruz Biotechnology, Inc ...
GADD34–PP1c recruited by Smad7 dephosphorylates TGFβ type I receptor
Cao Xu et al., In The Journal of Cell Biology, 1998
... A full-length wild-type Smad7 coding sequence was cloned into pGBKT7 (CLONTECH Laboratories, Inc.) to generate ...
Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles
O'Rahilly Steve, In PLoS Biology, 1996
... Plasmid TRE-Smad7 was constructed by inserting a 3.0-kb EcoRI-BamHI PCR clone of human Smad7 (hSmad7) [ 21] downstream of TRE, which consists of seven copies of the tet operator and a minimal CMV promoter (Clontech Laboratories, Palo Alto, California, ...
Papers on Smad7
Are SMAD7 rs4939827 and CHI3L1 rs4950928 polymorphisms associated with colorectal cancer in Egyptian patients?
Kamal et al., Cairo, Egypt. In Tumour Biol, Feb 2016
The SMAD7 gene encodes an intracellular protein, which inhibits the transforming growth factor beta (TGF-β) signaling pathway, thereby having a key role in the control of neoplastic processes in various organs.
Therapeutic innovations in inflammatory bowel diseases.
Vermeire et al., Leuven, Belgium. In Clin Pharmacol Ther, Jan 2016
In this review, we highlight the emerging new classes of IBD therapeutics under clinical evaluation and their method of action, including JAK inhibitors, anti-SMAD7 oligonucleotides, and cell-based therapies.
Antagonism of the met5-enkephalin-opioid growth factor receptor-signaling axis promotes MSC to differentiate into osteoblasts.
Margulies et al., In J Orthop Res, Jan 2016
Importantly, SMAD1 and SMAD8/9 expression increased after a pulse dose of naloxone while SMAD1, SMAD7 and ID1 were increased in the OGFR deficient MSC.
Aberrant TGFβ Signalling Contributes to Altered Trophoblast Differentiation in Preeclampsia.
Caniggia et al., Toronto, Canada. In Endocrinology, Jan 2016
Here, we show that TGFβ receptor-regulated SMAD2 was activated (Ser(465/467) phosphorylation) in syncytiotrophoblast and proliferating extravillous trophoblast cells of first trimester placenta, while inhibitory SMAD7 located primarily to cytotrophoblast cells.
Bone Morphogenetic Protein-6 (BMP-6) Stimulates the Antrum Formation by the Regulation of its Signalling Pathway in Caprine Pre-antral Follicles Cultured In Vitro.
Figueiredo et al., Fortaleza, Brazil. In Reprod Domest Anim, Jan 2016
Thus, this study investigated the effect of bone morphogenetic protein (BMP-6) and recombinant follicle-stimulating hormone (rFSH) alone or in combination on the in vitro culture (IVC) of isolated caprine secondary follicles (Experiment 1) and the mRNA levels for BMP receptors/Smad signalling pathway (BMPR1A, BMPR2, SMAD1, SMAD4, SMAD5, SMAD6, SMAD7 and SMAD8) in vivo and in vitro using BMP-6 (Experiment 2).
The human RNA surveillance factor UPF1 regulates tumorigenesis by targeting Smad7 in hepatocellular carcinoma.
Liu et al., Wuhan, China. In J Exp Clin Cancer Res, Dec 2015
The relationship between UPF1 and SMAD7 was also investigated by western blotting and immunofluorescence.
Progress in corneal wound healing.
Saghizadeh et al., Los Angeles, United States. In Prog Retin Eye Res, Nov 2015
Successful surgical ways of replacing the diseased endothelium have been clinically tested, and new approaches to accelerate endothelial healing and suppress endothelial-mesenchymal transformation have been proposed including Rho kinase (ROCK) inhibitor eye drops and gene therapy to activate TGF-β inhibitor SMAD7.
Next-Generation Therapeutics for IBD.
D'Haens et al., Amsterdam, Netherlands. In Curr Gastroenterol Rep, Jun 2015
Other therapeuticals that might find their way to the market the coming years include the anti-mucosal vascular addressin cell adhesion molecule (MAdCAM) PF-00547659, small molecules (including laquinimod and the CCR9 antagonist Vercirnon), as well as an orally active SMAD7 antisense oligonucleotide that showed clinical benefit in Crohn's disease patients.
Mongersen, an oral SMAD7 antisense oligonucleotide, and Crohn's disease.
Pallone et al., Palermo, Italy. In N Engl J Med, Apr 2015
BACKGROUND: Crohn's disease-related inflammation is characterized by reduced activity of the immunosuppressive cytokine transforming growth factor β1 (TGF-β1) due to high levels of SMAD7, an inhibitor of TGF-β1 signaling.
Analysis of differentially expressed genes based on microarray data of glioma.
Zhou et al., Nanjing, China. In Int J Clin Exp Med, 2014
In addition, the transcription factor analysis showed these DEGs were regulated by the binding sites of transcription factors GLI2, SP1, SMAD7, SMAD3, RELA, STAT5B, CTNNB1, STAT5A, TFAP2A and SP3.
New tricks for an old fox: impact of TGFβ on the DNA damage response and genomic stability.
Cucinotta et al., New York City, United States. In Sci Signal, 2014
Recent studies have shown that SMAD2 and SMAD7 participate in the DDR in a manner dependent on ATM or TGFβ receptor type I, respectively, in human fibroblasts and epithelial cells.
Granulosa cell function and oocyte competence: Super-follicles, super-moms and super-stimulation in cattle.
Singh et al., Saskatoon, Canada. In Anim Reprod Sci, 2014
The highest rates of blastocyst development in vitro were obtained when FSH support was discontinued for 44 to 68h and granulosa cell SMAD7 mRNA was predictive of this period.
USP4 is regulated by AKT phosphorylation and directly deubiquitylates TGF-β type I receptor.
ten Dijke et al., Leiden, Netherlands. In Nat Cell Biol, 2012
TβRI is targeted for ubiquitylation-mediated degradation by the SMAD7-SMURF2 complex.
APC and Smad7 link TGFβ type I receptors to the microtubule system to promote cell migration.
Landström et al., Uppsala, Sweden. In Mol Biol Cell, 2012
The Smad7-APC complex links the TGFbeta type I receptor to the microtubule system to regulate directed cellular extension and migratory responses evoked by TGFbeta.
Smad7 is a transforming growth factor-beta-inducible mediator of apoptosis in granulosa cells.
McGee et al., Richmond, United States. In Fertil Steril, 2012
Smad7 mediates apoptosis induced by TGF-beta in mouse granulosa cells, suggesting that dysregulation of Smad7 could impair folliculogenesis.
Loss of angiotensin-converting enzyme 2 enhances TGF-β/Smad-mediated renal fibrosis and NF-κB-driven renal inflammation in a mouse model of obstructive nephropathy.
Lan et al., Hong Kong, Hong Kong. In Lab Invest, 2012
Loss of renal Smad7 is an underlying mechanism required for the promotion of TGF-b/Smad-mediated renal fibrosis and NF-kappaB-driven renal inflammation in the unilateral ureteral obstructive (UUO) nephropathy.
USP15 stabilizes TGF-β receptor I and promotes oncogenesis through the activation of TGF-β signaling in glioblastoma.
Seoane et al., Barcelona, Spain. In Nat Med, 2012
USP15 binds to the SMAD7-SMAD specific E3 ubiquitin protein ligase 2 (SMURF2) complex and deubiquitinates and stabilizes type I TGF-β receptor (TβR-I), leading to an enhanced TGF-β signal.
A common SMAD7 variant is associated with risk of colorectal cancer: evidence from a case-control study and a meta-analysis.
Miao et al., Wuhan, China. In Plos One, 2011
Results from our case-control study and the meta-analysis collectively confirmed the significant association of the SMAD7 variant rs4939827 with increased risk of colorectal cancer
[Dynamic expression of TGF-beta1/Smad protein in CCl4-induced liver fibrosis and its significance in rats].
Xu et al., Hangzhou, China. In Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi, 2011
The upregulation of TGF-beta1, Smad2/3 and Smad7 in liver tissue is involved in the progression of hepatic fibrosis.
A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk.
Houlston et al., United Kingdom. In Nat Genet, 2007
Single nucleotide polymorphism in SMAD7 is associated with colorectal cancer
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