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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

MAD homolog 5

Smad5
The protein encoded by this gene is involved in the TGF-beta signaling pathway that results in an inhibition of the proliferation of hematopoietic progenitor cells. The encoded protein is activated by BMP type 1 receptor kinase. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Oct 2011] (from NCBI)
Top mentioned proteins: Smad1, Smad4, Smad2, miR, BMPR1A
Papers on Smad5
Bone Morphogenic Protein 4-Smad-Induced Upregulation of Platelet-Derived Growth Factor AA Impairs Endothelial Function.
New
Huang et al., Hong Kong, Hong Kong. In Arterioscler Thromb Vasc Biol, Feb 2016
SMAD4-shRNA lentivirus, SMAD1-shRNA, and SMAD5 shRNA adenovirus were used for knockdown in human endothelial cells.
BMP Sustains Embryonic Stem Cell Self-Renewal through Distinct Functions of Different Krüppel-like Factors.
New
Miyazono et al., Uppsala, Sweden. In Stem Cell Reports, Feb 2016
SMAD1 and SMAD5, which transduce BMP signals, recognize enhancer regions together with KLF4 and KLF5 in naive mESCs.
Activin B induces noncanonical SMAD1/5/8 signaling via BMP type I receptors in hepatocytes: evidence for a role in hepcidin induction by inflammation in male mice.
New
Babitt et al., Reggio nell'Emilia, Italy. In Endocrinology, Feb 2016
Activin B stimulates hepcidin via classical Activin type II receptors ACVR2A and ACVR2B, noncanonical BMP type I receptors ALK2 and ALK3, and SMAD5.
A functional variant in miR-155 regulation region contributes to lung cancer risk and survival.
New
Hu et al., Nanjing, China. In Oncotarget, Jan 2016
Furthermore, using functional assays and The Cancer Genome Atlas (TCGA) Lung Adenocarcinoma (LUAD) dataset, we found that rs767649 variant allele could increase the transcriptional activity of miR-155, which in turn facilitated tumor growth and metastasis by inhibiting HBP1, TJP1, SMAD5 and PRKAR1A expression.
Bone Morphogenetic Protein-6 (BMP-6) Stimulates the Antrum Formation by the Regulation of its Signalling Pathway in Caprine Pre-antral Follicles Cultured In Vitro.
New
Figueiredo et al., Fortaleza, Brazil. In Reprod Domest Anim, Jan 2016
Thus, this study investigated the effect of bone morphogenetic protein (BMP-6) and recombinant follicle-stimulating hormone (rFSH) alone or in combination on the in vitro culture (IVC) of isolated caprine secondary follicles (Experiment 1) and the mRNA levels for BMP receptors/Smad signalling pathway (BMPR1A, BMPR2, SMAD1, SMAD4, SMAD5, SMAD6, SMAD7 and SMAD8) in vivo and in vitro using BMP-6 (Experiment 2).
Zinc affects miR-548n, SMAD4, SMAD5 expression in HepG2 hepatocyte and HEp-2 lung cell lines.
New
Tripp et al., Athens, United States. In Biometals, Dec 2015
The purpose of this study was to determine the effects of Zn concentration in cell culture on the expression of miR-548n, SMAD4 and SMAD5 in hepatocyte (HepG2) and lung epithelium (HEp-2) cell lines.
Identification and characterization of miRNAs in the ovaries of a highly prolific sheep breed.
New
Li et al., Beijing, China. In Anim Genet, Dec 2015
Among the target genes, intracellular transducers (SMAD1, SMAD4, SMAD5 and SMAD9) and bone morphogenetic protein (BMP) receptors (BMPR1B and BMPR2) were involved in the transforming growth factor β (TGFβ) signaling pathway in the reproductive axis, and the most significant GO terms were intracellular part (GO:0044424), binding (GO:0005488) and biological_process (GO:0008150) for cellular component, molecular function and biological process respectively.
Heterozygous Mutations in BMP6 Pro-peptide Lead to Inappropriate Hepcidin Synthesis and Moderate Iron Overload in Humans.
New
Tchernitchko et al., Paris, France. In Gastroenterology, Dec 2015
In cell lines, the mutated residues in the BMP6 propeptide resulted in defective secretion of BMP6; reduced signaling via SMAD1, SMAD5, and SMAD8; and loss of hepcidin production.
miR-135b suppresses tumorigenesis in glioblastoma stem-like cells impairing proliferation, migration and self-renewal.
New
Ricci-Vitiani et al., Roma, Italy. In Oncotarget, Dec 2015
We identified ADAM12 and confirmed SMAD5 and GSK3β as miR-135b targets and potential mediators of its effects.
miR-23a and miR-27a promote human granulosa cell apoptosis by targeting SMAD5.
New
Yang et al., Beijing, China. In Biol Reprod, Oct 2015
Based on the results of a luciferase-reporter assay and quantitative RT-PCR and Western blotting analyses, we found that SMAD5 is a target gene of both miR-23a and miR-27a.
Overexpression of the BMP4/SMAD signaling pathway in skull base chordomas is associated with poor prognosis.
Li et al., Beijing, China. In Int J Clin Exp Pathol, 2014
To explore the role of the canonical BMP4/SMAD signaling pathway in the pathogenesis of chordoma, we investigated, in 40 skull base chordomas, the expression of three major components of the signaling axis: BMP4, phospho-SMAD5 and SMAD4.
Antisense Oligonucleotide-Mediated Transcript Knockdown in Zebrafish.
Schier et al., Coralville, United States. In Plos One, 2014
ASO-mediated transcript knockdown reproduced the published loss-of-function phenotypes for oep, chordin, dnd, ctnnb2, bmp7a, alk8, smad2 and smad5 in a dosage-sensitive manner.
Recurrent somatic mutations in ACVR1 in pediatric midline high-grade astrocytoma.
Impact
Kieran et al., Montréal, Canada. In Nat Genet, 2014
Hyperactivation of the bone morphogenetic protein (BMP)-ACVR1 developmental pathway in mHGAs harboring ACVR1 mutations led to increased levels of phosphorylated SMAD1, SMAD5 and SMAD8 and upregulation of BMP downstream early-response genes in tumor cells.
Antagonism of Nodal signaling by BMP/Smad5 prevents ectopic primitive streak formation in the mouse amnion.
GeneRIF
Zwijsen et al., Leuven, Belgium. In Development, 2012
Data conclude that antagonism of Nodal signaling by BMP/Smad5 signaling prevents primitive streak formation in the amnion of normal mouse embryos.
Inhibition of mTORC1 kinase activates Smads 1 and 5 but not Smad8 in human prostate cancer cells, mediating cytostatic response to rapamycin.
GeneRIF
Danielpour et al., Cleveland, United States. In Mol Cancer Res, 2012
Data suggest that Smads 1, 5 and 8 as potential prognostic markers and therapeutic targets for mTOR inhibition therapy of prostate cancer.
Intra-axonal translation of SMAD1/5/8 mediates retrograde regulation of trigeminal ganglia subtype specification.
GeneRIF
Jaffrey et al., New York City, United States. In Neuron, 2012
SMAD1, 5, and 8 transcripts are localized to trigeminal ganglia axons and these mRNAs are selectively translated in response to BDNF.
Stalk cell phenotype depends on integration of Notch and Smad1/5 signaling cascades.
GeneRIF
Zwijsen et al., Leuven, Belgium. In Dev Cell, 2012
The findings provide in vivo evidence for a regulatory loop between BMP/TGFbeta-Smad1/5 and Notch/dll4 signaling that orchestrates tip- versus stalk-cell selection and vessel plasticity in angiogenesis.
Smad1/Smad5 signaling in limb ectoderm functions redundantly and is required for interdigital programmed cell death.
GeneRIF
Kwan et al., Hong Kong, Hong Kong. In Dev Biol, 2012
Data show that the Smad1/Smad5 double mutants exhibited syndactyly due to a reduction in interdigital PCD and an increase in interdigital cell proliferation.
BMP type I receptor inhibition reduces heterotopic [corrected] ossification.
Impact
Bloch et al., In Nat Med, 2008
6), inhibits activation of the BMP signaling effectors SMAD1, SMAD5 and SMAD8 in tissues expressing caALK2 induced by adenovirus specifying Cre (Ad.Cre).
Bone morphogenetic protein-7 (BMP7) in chronic kidney disease.
Review
Hirschberg et al., Torrance, United States. In Front Biosci, 2007
These antifibrogenic activities result from inhibition of the nuclear translocation of TGFbeta-activated smad3 by smad6 downstream of BMP7-activated smad5.
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