A role for the mitogen-activated protein kinase kinase kinase 1 in epithelial wound healing.
In PLoS ONE, 2005
... as antibodies for phospho-c-Jun (Ser-63, 73), phospho-ATF2 (Thr-69, 71), phospho-p65 (Ser-536), phospho-SMAD2 (Ser-465, 467) and phospho-SMAD3 (Ser-423, 425), were purchased from Cell Signaling Technology (Danvers, MA); Antibodies ... TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivomore suppliers
In The American Journal of Pathology, 2004
... TAK1 (4505; Cell Signaling, Danvers, MA), phospho-TAK1 (4536; Cell Signaling), SMAD3 (ab29379; Abcam, Cambridge, UK), phospho-SMAD3 (ab52903; ...
Expression of TGF-beta Superfamily Growth Factors, their Receptors, the Associated SMADs and Antagonists in Five Isolated Size-matched Populations of Preantral Follicles from Normal Human Ovaries.
Copenhagen, Denmark. In Mol Hum Reprod, 22 Dec 2013
Selected proteins/genes were analysed by immunocytochemistry and quantitative RT-PCR.TGF-β superfamily genes with overall highest mRNA expressions levels included growth differentiation factors 9 (GDF9), bone morphogenic protein-15 (BMP15), BMP6, BMP-receptor-2 (BMPR2), anti-Müllerian hormone receptor 2 (AMHR2), TGFβR3, inhibin-α (INHA), and intracellular SMAD3 and SMAD4.
Mycophenolic Acid Inhibits Migration and Invasion of Gastric Cancer Cells via Multiple Molecular Pathways.
Guangzhou, China. In Plos One, Dec 2012
Our results indicate that MPA modulates gastric cancer cell migration through down-regulation of a large number of genes (PRKCA, DOCK1, INF2, HSPA5, LRP8 and PDGFRA) and proteins (PRKCA, AKT, SRC, CD147 and MMP1) with promigratory functions as well as up-regulation of a number of genes with antimigratory functions (ATF3, SMAD3, CITED2 and CEAMCAM1).
Loss-of-function mutations in TGFB2 cause a syndromic presentation of thoracic aortic aneurysm.
Baltimore, United States. In Nat Genet, Aug 2012
Loeys-Dietz syndrome (LDS) associates with a tissue signature for high transforming growth factor (TGF)-β signaling but is often caused by heterozygous mutations in genes encoding positive effectors of TGF-β signaling, including either subunit of the TGF-β receptor or SMAD3, thereby engendering controversy regarding the mechanism of disease.
Genetics of thoracic aortic aneurysms.
Paris, France. In Curr Atheroscler Rep, Jun 2012
Beyond Marfan syndrome, usually related to mutation in FBN1, mutations have been reported in TGFBR1, TGFBR2, ACTA2, MYH11, and SMAD3.
Genetics of osteoarthritis.
More papers using
Newcastle upon Tyne, United Kingdom. In Curr Opin Rheumatol, 2011
If one relaxes slightly, other signals emerge, such as DIO2, SMAD3 and ASPN.
Transforming growth factor-beta-induced inhibition of myogenesis is mediated through Smad pathway and is modulated by microtubule dynamic stability
In The Journal of Cell Biology, 2003
... (clone 9E10), SRF, CTGF (Santa Cruz Biotechnology, Inc.), GAPDH (EMD), histones, α1-integrin, paxillin (Millipore), PAI-1, Smad3 (Abcam), FAK, zonula occludens-1, phospho-FAK ...