A role for the mitogen-activated protein kinase kinase kinase 1 in epithelial wound healing.
In PLoS ONE, 2005
... as antibodies for phospho-c-Jun (Ser-63, 73), phospho-ATF2 (Thr-69, 71), phospho-p65 (Ser-536), phospho-SMAD2 (Ser-465, 467) and phospho-SMAD3 (Ser-423, 425), were purchased from Cell Signaling Technology (Danvers, MA); Antibodies ... TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivomore suppliers
In The American Journal of Pathology, 2004
... TAK1 (4505; Cell Signaling, Danvers, MA), phospho-TAK1 (4536; Cell Signaling), SMAD3 (ab29379; Abcam, Cambridge, UK), phospho-SMAD3 (ab52903; ...
Loss-of-function mutations in TGFB2 cause a syndromic presentation of thoracic aortic aneurysm.
Baltimore, United States. In Nat Genet, Aug 2012
Loeys-Dietz syndrome (LDS) associates with a tissue signature for high transforming growth factor (TGF)-β signaling but is often caused by heterozygous mutations in genes encoding positive effectors of TGF-β signaling, including either subunit of the TGF-β receptor or SMAD3, thereby engendering controversy regarding the mechanism of disease.
Genetics of thoracic aortic aneurysms.
Paris, France. In Curr Atheroscler Rep, Jun 2012
Beyond Marfan syndrome, usually related to mutation in FBN1, mutations have been reported in TGFBR1, TGFBR2, ACTA2, MYH11, and SMAD3.
New IBD genetics: common pathways with other diseases.
Edinburgh, United Kingdom. In Gut, 2011
Amongst these are multiple genes involved in IL23/Th17 signalling (IL23R, IL12B, JAK2, TYK2 and STAT3), IL10, IL1R2, REL, CARD9, NKX2.3, ICOSLG, PRDM1, SMAD3 and ORMDL3.
Genetics of osteoarthritis.
Newcastle upon Tyne, United Kingdom. In Curr Opin Rheumatol, 2011
If one relaxes slightly, other signals emerge, such as DIO2, SMAD3 and ASPN.
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
More papers using
Kiel, Germany. In Nat Genet, 2010
A series of in silico analyses highlighted particular genes within these loci and, together with manual curation, implicated functionally interesting candidate genes including SMAD3, ERAP2, IL10, IL2RA, TYK2, FUT2, DNMT3A, DENND1B, BACH2 and TAGAP.
Transforming growth factor-beta-induced inhibition of myogenesis is mediated through Smad pathway and is modulated by microtubule dynamic stability
In The Journal of Cell Biology, 2003
... (clone 9E10), SRF, CTGF (Santa Cruz Biotechnology, Inc.), GAPDH (EMD), histones, α1-integrin, paxillin (Millipore), PAI-1, Smad3 (Abcam), FAK, zonula occludens-1, phospho-FAK ...