A role for the mitogen-activated protein kinase kinase kinase 1 in epithelial wound healing.
In PLoS ONE, 2005
... as antibodies for phospho-c-Jun (Ser-63, 73), phospho-ATF2 (Thr-69, 71), phospho-p65 (Ser-536), phospho-SMAD2 (Ser-465, 467) and phospho-SMAD3 (Ser-423, 425), were purchased from Cell Signaling Technology (Danvers, MA); Antibodies ... TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivomore suppliers
In The American Journal of Pathology, 2004
... TAK1 (4505; Cell Signaling, Danvers, MA), phospho-TAK1 (4536; Cell Signaling), SMAD3 (ab29379; Abcam, Cambridge, UK), phospho-SMAD3 (ab52903; ...
Inducible Nitric Oxide Synthase (iNOS) Regulatory Region Variation in Non-Human Primates.
Santa Fe, United States. In Infect Genet Evol, 09 Mar 2015
Specifically, we found evidence of 13 conserved binding site candidates linked to iNOS regulation: AP-1,C/EBPB,CREB,GATA-1,GATA-3,NF-AT,NF-AT5,NF-κB,KLF4,Oct-1,PEA3,SMAD3, and TCF11.
Antwerp, Belgium. In Adv Exp Med Biol, 2013
The genetic cause is heterogeneous and includes mutations in genes encoding for components of the transforming growth factor beta (TGFβ) signalling pathway: TGFBR1, TGFBR2, SMAD3 and TGFB2.
Loss-of-function mutations in TGFB2 cause a syndromic presentation of thoracic aortic aneurysm.
Baltimore, United States. In Nat Genet, 2012
Loeys-Dietz syndrome (LDS) associates with a tissue signature for high transforming growth factor (TGF)-β signaling but is often caused by heterozygous mutations in genes encoding positive effectors of TGF-β signaling, including either subunit of the TGF-β receptor or SMAD3, thereby engendering controversy regarding the mechanism of disease.
Genetics of thoracic aortic aneurysms.
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Paris, France. In Curr Atheroscler Rep, 2012
Beyond Marfan syndrome, usually related to mutation in FBN1, mutations have been reported in TGFBR1, TGFBR2, ACTA2, MYH11, and SMAD3.
Transforming growth factor-beta-induced inhibition of myogenesis is mediated through Smad pathway and is modulated by microtubule dynamic stability
In The Journal of Cell Biology, 2003
... (clone 9E10), SRF, CTGF (Santa Cruz Biotechnology, Inc.), GAPDH (EMD), histones, α1-integrin, paxillin (Millipore), PAI-1, Smad3 (Abcam), FAK, zonula occludens-1, phospho-FAK ...