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SMAD family member 3

Smad3
The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions as a transcriptional modulator activated by transforming growth factor-beta and is thought to play a role in the regulation of carcinogenesis. [provided by RefSeq, Apr 2009] (from NCBI)
Top mentioned proteins: Smad2, TGF-beta, Smad4, V1a, CAN
Papers using Smad3 antibodies
Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase.
Supplier
Gullberg Donald, In PLoS ONE, 2011
... UK); polyclonal GFP antibody from MBL International (Woburn, MA, USA); monoclonal GFP, polyclonal tryptase, polyclonal Smad3 and pSmad3 antibodies from Santa Cruz Biotechnology (Santa Cruz, CA, USA); ...
Pim kinase substrate identification and specificity
Supplier
Sapkota Gopal P. et al., In Open Biology, 2006
... Phospho-SMAD3 Ser423/425 antibody was from Rockland Inc ...
A role for the mitogen-activated protein kinase kinase kinase 1 in epithelial wound healing.
Supplier
Connon Che John, In PLoS ONE, 2005
... as antibodies for phospho-c-Jun (Ser-63, 73), phospho-ATF2 (Thr-69, 71), phospho-p65 (Ser-536), phospho-SMAD2 (Ser-465, 467) and phospho-SMAD3 (Ser-423, 425), were purchased from Cell Signaling Technology (Danvers, MA); Antibodies ...
TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo
Supplier
Borthwick Lee A. et al., In The American Journal of Pathology, 2004
... TAK1 (4505; Cell Signaling, Danvers, MA), phospho-TAK1 (4536; Cell Signaling), SMAD3 (ab29379; Abcam, Cambridge, UK), phospho-SMAD3 (ab52903; ...
Receptor-independent actions of PPAR thiazolidinedione agonists: is mitochondrial function the key?
Supplier
Bourke Jane E et al., In Respiratory Research, 2004
... Rabbit monoclonal antibodies against human Smad2 and Smad3, and phosphorylated Smad2 and Smad3 were from Cell Signaling Technology (Beverly, MA) ...
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Papers on Smad3
Expansion and long-term culture of human spermatogonial stem cells via the activation of SMAD3 and AKT pathways.
New
He et al., Shanghai, China. In Exp Biol Med (maywood), 18 Jul 2015
Furthermore, SMAD3 and AKT phosphorylation was enhanced during the culture of human SSCs.
Glycogen synthase kinase-3 inhibition attenuates fibroblast activation and development of fibrosis following renal ischemia/reperfusion in mice.
New
Rao et al., Kansas City, United States. In Dis Model Mech, 18 Jul 2015
GSK3 inhibition in vivo reduced TGF-β1, SMAD3 activation and plasminogen activator inhibitor-1 levels.
β-Catenin Regulates Primitive Streak Induction through Collaborative Interactions with SMAD2/SMAD3 and OCT4.
New
Impact
Semb et al., Copenhagen, Denmark. In Cell Stem Cell, 04 Jul 2015
β-catenin occupies regulatory regions in numerous PS and neural crest genes, and direct interactions between β-catenin and the Nodal effectors SMAD2/SMAD3 are required at these regions for PS gene activation.
Platelet-Derived Growth Factor and Transforming Growth Factor β1 Regulate ARDS-Associated Lung Fibrosis Through Distinct Signaling Pathways.
New
Zhou et al., Shanghai, China. In Cell Physiol Biochem, Dec 2014
METHOD: We treated human lung fibroblasts (HLF) with PDGF, or TGFβ1, or combined, and examined the activation of p38 MAPK, p42/p44 MAPK and SMAD3.
Characterization of SMAD3 Gene Variants for Possible Roles in Ventricular Septal Defects and Other Congenital Heart Diseases.
New
Liu et al., Harbin, China. In Plos One, Dec 2014
SMAD3 is a key intracellular messenger regulating factor in the Nodal/TGF signaling pathway, playing important roles in embryonic and, particularly, cardiovascular system development.
Pathophysiological role of microRNA-29 in pancreatic cancer stroma.
New
Kota et al., Indianapolis, United States. In Sci Rep, Dec 2014
Furthermore, the loss of miR-29 in TGF-β1 activated PSCs is SMAD3 dependent.
DEAR1, a novel tumor suppressor that regulates cell polarity and epithelial plasticity.
Review
New
Killary et al., Houston, United States. In Cancer Res, Nov 2014
DEAR1 binds to and promotes the ubiquitination of SMAD3, the major effector of TGFβ-mediated EMT, as well as downregulates SMAD3 targets SNAIL1/2, master transcriptional regulators of EMT.
Histone demethylase Jumonji D3 (JMJD3/KDM6B) at the nexus of epigenetic regulation of inflammation and the aging process.
Review
New
Kauppinen et al., Kuopio, Finland. In J Mol Med (berl), Oct 2014
Moreover, JMJD3 can activate TGF-β signaling through the SMAD3 pathway.
Adult granulosa cell tumours of the ovary.
Review
New
Colombo et al., Roma, Italy. In Curr Opin Oncol, Sep 2014
RECENT FINDINGS: Novel biomarkers, including FOXL2, SMAD3 and GATA4, have been identified as potential diagnostic and therapeutic targets for this type of tumour.
HLA and asthma phenotypes/endotypes: a review.
Review
New
Daniilidis et al., Thessaloníki, Greece. In Hum Immunol, Aug 2014
Genome-wide association studies (GWAS) represent the most powerful approach for asthma, that have identified several genes (e.g., IL18R1, IL33, SMAD3, ORMDL3, HLA-DQ and IL2RB loci).
WWOX at the crossroads of cancer, metabolic syndrome related traits and CNS pathologies.
Review
New
Abba et al., United States. In Biochim Biophys Acta, Aug 2014
Supporting these conclusions recently we demonstrated that indeed WWOX behaves as a modulator of TGFβ/SMAD signaling by binding and sequestering SMAD3 in the cytoplasmic compartment.
Ossifying fibroma tumor stem cells are maintained by epigenetic regulation of a TSP1/TGF-β/SMAD3 autocrine loop.
Impact
Shi et al., Los Angeles, United States. In Cell Stem Cell, 2013
The elevated TGF-β activity is tightly regulated by JHDM1D-mediated epigenetic regulation of thrombospondin-1 (TSP1), forming a JHDM1D/TSP1/TGF-β/SMAD3 autocrine loop.
A vitamin D receptor/SMAD genomic circuit gates hepatic fibrotic response.
Impact
Evans et al., Los Angeles, United States. In Cell, 2013
Mechanistically, we show that TGFβ1 signaling causes a redistribution of genome-wide VDR-binding sites (VDR cistrome) in HSCs and facilitates VDR binding at SMAD3 profibrotic target genes via TGFβ1-dependent chromatin remodeling.
Metabolomics identifies an inflammatory cascade involved in dioxin- and diet-induced steatohepatitis.
Impact
Gonzalez et al., Bethesda, United States. In Cell Metab, 2012
The decreased CES3 expression was accomplished by TCDD-stimulated TGFβ-SMAD3 and IL6-STAT3 signaling, but not by direct AhR signaling.
Zyxin is a transforming growth factor-β (TGF-β)/Smad3 target gene that regulates lung cancer cell motility via integrin α5β1.
GeneRIF
Eickelberg et al., München, Germany. In J Biol Chem, 2012
Zyxin is a transforming growth factor-beta (TGF-beta)/Smad3 target gene that regulates lung cancer cell motility via integrin alpha5beta1.
Smad3 binding to the foxp3 enhancer is dispensable for the development of regulatory T cells with the exception of the gut.
GeneRIF
von Boehmer et al., Boston, United States. In J Exp Med, 2012
binding of Smad3 to the foxp3 enhancer is dispensable for regulatory T cell development in newborn and adult mice with the exception of the gut
Genome-wide analysis reveals that Smad3 and JMJD3 HDM co-activate the neural developmental program.
GeneRIF
Martínez-Balbás et al., Barcelona, Spain. In Development, 2012
neurogenesis is promoted by an interplay between the TGFbeta pathway, Smad3, and the H3K27me3 histone demethylase (HDM) JMJD3
Loss-of-function mutations in TGFB2 cause a syndromic presentation of thoracic aortic aneurysm.
Impact
Loeys et al., Baltimore, United States. In Nat Genet, 2012
Loeys-Dietz syndrome (LDS) associates with a tissue signature for high transforming growth factor (TGF)-β signaling but is often caused by heterozygous mutations in genes encoding positive effectors of TGF-β signaling, including either subunit of the TGF-β receptor or SMAD3, thereby engendering controversy regarding the mechanism of disease.
Dynamics of TGF-β/Smad signaling.
GeneRIF
Liu et al., Freiburg, Germany. In Febs Lett, 2012
analysis of the dynamics of TGF-beta and Smad2/Smad3 signaling [review]
Follistatin-mediated skeletal muscle hypertrophy is regulated by Smad3 and mTOR independently of myostatin.
GeneRIF
Gregorevic et al., Australia. In J Cell Biol, 2012
regulation of Smad3- and mTOR-dependent events by follistatin occurred independently of overexpression or knockout of myostatin, a key repressor of muscle development that can regulate Smad3 and mTOR signaling and that is itself inhibited by follistatin
More papers using Smad3 antibodies
Transforming growth factor-beta-induced inhibition of myogenesis is mediated through Smad pathway and is modulated by microtubule dynamic stability
Supplier
Kapus András et al., In The Journal of Cell Biology, 2003
... (clone 9E10), SRF, CTGF (Santa Cruz Biotechnology, Inc.), GAPDH (EMD), histones, α1-integrin, paxillin (Millipore), PAI-1, Smad3 (Abcam), FAK, zonula occludens-1, phospho-FAK ...
Adhesion of gastric carcinoma cells to peritoneum mediated by alpha3beta1 integrin (VLA-3)
Supplier
Xu Hui-Mian et al., In Journal of Experimental & Clinical Cancer Research : CR, 2003
... Total Smad-2/3, phosphorylated- Smad2 and phosphorylated- Smad3 antibodies, as well as second antibodies were purchased from Santa Cruz Biotechnology Inc, USA ...
Angiotensin II activates nuclear transcription factor kappaB through AT(1) and AT(2) in vascular smooth muscle cells: molecular mechanisms.
Supplier
Morty Rory Edward, In PLoS ONE, 1999
... Antibodies employed were: phosphorylated Smad3 (p-Smad3; Abcam for immunohistochemistry, ), pSmad3 ...
Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine
Supplier
Sánchez-Capelo Amelia et al., In Molecular Neurodegeneration, 1979
... For TH/Smad3 co-immunolabelling, amplification of the Smad3 signal was obtained using the TSA™ Plus Cyanine 3 System (PerkinElmer, Massachusetts) with some modifications ...
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