A role for the mitogen-activated protein kinase kinase kinase 1 in epithelial wound healing.
In PLoS ONE, 2005
... as antibodies for phospho-c-Jun (Ser-63, 73), phospho-ATF2 (Thr-69, 71), phospho-p65 (Ser-536), phospho-SMAD2 (Ser-465, 467) and phospho-SMAD3 (Ser-423, 425), were purchased from Cell Signaling Technology (Danvers, MA); Antibodies ... TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivomore suppliers
In The American Journal of Pathology, 2004
... TAK1 (4505; Cell Signaling, Danvers, MA), phospho-TAK1 (4536; Cell Signaling), SMAD3 (ab29379; Abcam, Cambridge, UK), phospho-SMAD3 (ab52903; ...
Genetics of hereditary large vessel diseases.
Ōsaka, Japan. In J Hum Genet, 08 Nov 2015
Genes identified for these diseases include FBN1, TGFBR1, TGFBR2, SMAD3, TGFB2, TGFB3, SKI, EFEMP2, COL3A1, FLNA, ACTA2, MYH11, MYLK and SLC2A10, as well as others.
Clinical Exome Sequencing as a Novel Tool for Diagnosing Loeys-Dietz Syndrome Type 3.
Ljubljana, Slovenia. In Eur J Vasc Endovasc Surg, 22 Oct 2015
The patient's diagnosis became evident after clinical exome sequencing detected a novel missense mutation in the evolutionary conserved region of SMAD3, confirming the diagnosis of Loeys-Dietz syndrome (LDS) type 3. A brief overview of the various types of LDS and their management is presented.
Loss-of-function mutations in TGFB2 cause a syndromic presentation of thoracic aortic aneurysm.
More papers using
Baltimore, United States. In Nat Genet, 2012
Loeys-Dietz syndrome (LDS) associates with a tissue signature for high transforming growth factor (TGF)-β signaling but is often caused by heterozygous mutations in genes encoding positive effectors of TGF-β signaling, including either subunit of the TGF-β receptor or SMAD3, thereby engendering controversy regarding the mechanism of disease.
Transforming growth factor-beta-induced inhibition of myogenesis is mediated through Smad pathway and is modulated by microtubule dynamic stability
In The Journal of Cell Biology, 2003
... (clone 9E10), SRF, CTGF (Santa Cruz Biotechnology, Inc.), GAPDH (EMD), histones, α1-integrin, paxillin (Millipore), PAI-1, Smad3 (Abcam), FAK, zonula occludens-1, phospho-FAK ...