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proteins. Page last changed on 14 Mar 2013.
SMAD family member 3
Smad3
The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions as a transcriptional modulator activated by transforming growth factor-beta and is thought to play a role in the regulation of carcinogenesis. [provided by RefSeq, Apr 2009] (from
NCBI)
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Papers using
Smad3
antibodies
Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase.
Supplier
In PLoS ONE, 2011
... UK); polyclonal GFP antibody from MBL International (Woburn, MA, USA); monoclonal GFP, polyclonal tryptase, polyclonal Smad3 and pSmad3 antibodies from Santa Cruz Biotechnology (Santa Cruz, CA, USA); ...
Pim kinase substrate identification and specificity
Supplier
In Open Biology, 2006
... Phospho-SMAD3 Ser423/425 antibody was from Rockland Inc ...
A role for the mitogen-activated protein kinase kinase kinase 1 in epithelial wound healing.
Supplier
In PLoS ONE, 2005
TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo
Supplier
In The American Journal of Pathology, 2004
... TAK1 (4505; Cell Signaling, Danvers, MA), phospho-TAK1 (4536; Cell Signaling), SMAD3 (ab29379; Abcam, Cambridge, UK), phospho-SMAD3 (ab52903; ...
Receptor-independent actions of PPAR thiazolidinedione agonists: is mitochondrial function the key?
more suppliersSupplier
In Respiratory Research, 2004
Papers on
Smad3
Peptide-mediated Inhibition of MK2 Ameliorates Bleomycin-Induced Pulmonary Fibrosis.
New
Indianapolis, United States. In Am J Respir Cell Mol Biol, 07 Apr 2013
MK2i also decreased circulating TNF-α and IL-6 levels and modulated local mRNA expression of pro-fibrotic cytokine il-1β, matrix-related genes-col1a2, col3a1, lox, and TGF-beta family members including smad3, serpine1 (pai1) and smad6/7.
NANOG promotes liver cancer cell invasion by inducing epithelial-mesenchymal transition through NODAL/SMAD3 signaling pathway.
New
Shanghai, China. In Int J Biochem Cell Biol, 06 Apr 2013
NANOG activates NODAL and CRIPTO-1 to promote SMAD3 phosphorylation and SNAIL expression.
Betaglycan Alters NFκB-TGFβ2 Cross Talk to Reduce Survival of Human Granulosa Tumor Cells.
New
Australia. In Mol Endocrinol, 31 Mar 2013
Furthermore, inhibiting NFκB activity resulted in a specific reduction in SMAD3 expression.
Inhibition of Overactive TGF-beta Signaling by Prostacyclin Analogues in Pulmonary Arterial Hypertension (PAH).
New
London, United Kingdom. In Am J Respir Cell Mol Biol, 15 Mar 2013
Finally, in a monocrotaline (MCT)-induced rat model of PAH, which is associated with increased TGF-β signaling, this study confirms that treprostinil (TPS), a stable prostacyclin analogue, inhibits the TGF-β pathway by reducing SMAD3 phosphorylation.
Effects of SGLT2 Inhibition in Human Kidney Proximal Tubular Cells-Renoprotection in Diabetic Nephropathy?
New
Sydney, Australia. In Plos One, Dec 2012
A chromatin immunoprecipitation assay was used to determine the binding of phosphorylated smad3 to the promoter region of the SGLT2 gene.
Metabolomics identifies an inflammatory cascade involved in dioxin- and diet-induced steatohepatitis.
New
Impact
Bethesda, United States. In Cell Metab, Dec 2012
The decreased CES3 expression was accomplished by TCDD-stimulated TGFβ-SMAD3 and IL6-STAT3 signaling, but not by direct AhR signaling.
Loss-of-function mutations in TGFB2 cause a syndromic presentation of thoracic aortic aneurysm.
New
Impact
Baltimore, United States. In Nat Genet, Aug 2012
Loeys-Dietz syndrome (LDS) associates with a tissue signature for high transforming growth factor (TGF)-β signaling but is often caused by heterozygous mutations in genes encoding positive effectors of TGF-β signaling, including either subunit of the TGF-β receptor or SMAD3, thereby engendering controversy regarding the mechanism of disease.
Genetics of thoracic aortic aneurysms.
Review
New
Paris, France. In Curr Atheroscler Rep, Jun 2012
Beyond Marfan syndrome, usually related to mutation in FBN1, mutations have been reported in TGFBR1, TGFBR2, ACTA2, MYH11, and SMAD3.
Genetic and genomic approaches to asthma: new insights for the origins.
Review
London, United Kingdom. In Curr Opin Pulm Med, 2012
The largest of these was from the GABRIEL consortium, which discovered that the IL18R1, IL33, SMAD3, ORMDL3, HLA-DQ and IL2RB loci were all significantly associated with asthma.
New IBD genetics: common pathways with other diseases.
Review
Edinburgh, United Kingdom. In Gut, 2011
Amongst these are multiple genes involved in IL23/Th17 signalling (IL23R, IL12B, JAK2, TYK2 and STAT3), IL10, IL1R2, REL, CARD9, NKX2.3, ICOSLG, PRDM1, SMAD3 and ORMDL3.
Androgen receptor transactivity is potentiated by TGF-β1 through Smad3 but checked by its coactivator Hic-5/ARA55 in balding dermal papilla cells.
GeneRIF
In J Dermatol Sci, 2011
Androgen receptor transactivity is potentiated by TGF-beta1 through Smad3 but checked by its coactivator Hic-5/ARA55 in balding dermal papilla cells.
USP15 is a deubiquitylating enzyme for receptor-activated SMADs.
Impact
GeneRIF
Padova, Italy. In Nat Cell Biol, 2011
USP15 is a deubiquitylating enzyme for receptor-activated SMAD3.
TRB3 interacts with SMAD3 promoting tumor cell migration and invasion.
GeneRIF
Beijing, China. In J Cell Sci, 2011
the TRB3-SMAD3 interaction promoted the nuclear localization of SMAD3 because of the interaction of TRB3 with the MH2 domain of SMAD3
cGMP inhibits TGF-beta signaling by sequestering Smad3 with cytosolic beta2-tubulin in pulmonary artery smooth muscle cells.
GeneRIF
Birmingham, United States. In Mol Endocrinol, 2011
Smad3 was bound to beta2-tubulin in a TGF-beta1/cGMP-dependent manner.
Smad3-mediated upregulation of miR-21 promotes renal fibrosis.
GeneRIF
Hong Kong, Hong Kong. In J Am Soc Nephrol, 2011
Smad3 signaling increases expression of miR-21, which promotes renal fibrosis.
Genetics of osteoarthritis.
Review
Newcastle upon Tyne, United Kingdom. In Curr Opin Rheumatol, 2011
If one relaxes slightly, other signals emerge, such as DIO2, SMAD3 and ASPN.
The kinases MEKK2 and MEKK3 regulate transforming growth factor-β-mediated helper T cell differentiation.
Impact
New Haven, United States. In Immunity, 2011
Map3k2(-/-)Map3k3(Lck-Cre/-) T cells exhibited impaired phosphorylation of SMAD2 and SMAD3 proteins at their linker regions, which negatively regulated the TGF-β responses in T cells.
Mutations in SMAD3 cause a syndromic form of aortic aneurysms and dissections with early-onset osteoarthritis.
Impact
GeneRIF
Rotterdam, Netherlands. In Nat Genet, 2011
SMAD3 mutations in the TGF-beta pathway cause a syndromic form of aortic aneurysms and dissections with early-onset osteoarthritis
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
Impact
Kiel, Germany. In Nat Genet, 2010
A series of in silico analyses highlighted particular genes within these loci and, together with manual curation, implicated functionally interesting candidate genes including SMAD3, ERAP2, IL10, IL2RA, TYK2, FUT2, DNMT3A, DENND1B, BACH2 and TAGAP.
The transforming growth factor beta 1/SMAD signaling pathway involved in human chronic myeloid leukemia.
More papers using
Smad3
antibodies
Review
China. In Tumori, 2010
Upon binding on TGF-beta1, the dimerized TGF-beta type II receptors recruit and phosphorylate the TGF-beta type I receptors, which phosphorylate the receptor-regulated SMAD (SMAD2 and SMAD3) presented by the SMAD anchor for receptor activation.
Transforming growth factor-beta-induced inhibition of myogenesis is mediated through Smad pathway and is modulated by microtubule dynamic stability
Supplier
In The Journal of Cell Biology, 2003
... (clone 9E10), SRF, CTGF (Santa Cruz Biotechnology, Inc.), GAPDH (EMD), histones, α1-integrin, paxillin (Millipore), PAI-1, Smad3 (Abcam), FAK, zonula occludens-1, phospho-FAK ...
Adhesion of gastric carcinoma cells to peritoneum mediated by alpha3beta1 integrin (VLA-3)
Supplier
In Journal of Experimental & Clinical Cancer Research : CR, 2003
... Total Smad-2/3, phosphorylated- Smad2 and phosphorylated- Smad3 antibodies, as well as second antibodies were purchased from Santa Cruz Biotechnology Inc, USA ...
Angiotensin II activates nuclear transcription factor kappaB through AT(1) and AT(2) in vascular smooth muscle cells: molecular mechanisms.
Supplier
In PLoS ONE, 1999
... Antibodies employed were: phosphorylated Smad3 (p-Smad3; Abcam for immunohistochemistry, ), pSmad3 ...
Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine
Supplier
In Molecular Neurodegeneration, 1979
... For TH/Smad3 co-immunolabelling, amplification of the Smad3 signal was obtained using the TSA™ Plus Cyanine 3 System (PerkinElmer, Massachusetts) with some modifications ...
