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SMAD family member 2

Smad2
The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: TGF-beta, Smad3, Smad4, CAN, V1a
Papers using Smad2 antibodies
Nuclear factor I-C links platelet-derived growth factor and transforming growth factor beta1 signaling to skin wound healing progression.
Supplier
Lee Sean Bong, In PLoS ONE, 2008
... Rabbit anti-p-Smad3 and total Smad2/3 antibodies were purchased from Cell Signaling Technology (Danvers, MA) ...
GADD34-PP1c recruited by Smad7 dephosphorylates TGF type I receptor.
Supplier
Goumans Marie Jose, In PLoS ONE, 2003
... The antibodies used were as follows: anti-phospho-Smad2 (Ser465/467) (138D4) and anti-Smad2 (L16D3) antibodies were purchased from Cell Signaling.
The emerging role of lysophosphatidic acid in cancer
Supplier
Quaranta Vito et al., In Journal of Oncology, 2002
... Polyclonal antibody (pAb) against phosphorylated Smad2 (Ser465/467), GAPDH, and monoclonal antibody (mAb) against Smad2/3 were purchased from Cell Signaling Technology (Danvers, MA), BD ...
Hmg-CoA reductase inhibitor modulates monocyte-endothelial cell interaction under physiological flow conditions in vitro: involvement of Rho GTPase-dependent mechanism
Supplier
Kim Jae Ho et al., In Experimental & Molecular Medicine, 2000
... Anti-phospho-Smad2 (Ser465/467) and anti-Smad2 antibodies were obtained from Cell Signaling Technology (Beverly, MA) ...
CHMP5 is essential for late endosome function and down-regulation of receptor signaling during mouse embryogenesis
Supplier
Ghosh Sankar et al., In The Journal of Cell Biology, 1999
... The antibodies used were anti–phospho-Erk1/2 (Cell Signaling Technology), anti–phospho-Smad2 (Cell Signaling Technology), anti-Smad4 (Santa Cruz ...
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Papers on Smad2
Follicle-stimulating hormone promotes age-related endometrial atrophy through cross-talk with transforming growth factor beta signal transduction pathway.
New
Huang et al., Hangzhou, China. In Aging Cell, 13 Dec 2014
Furthermore, smad2 and smad3 showed a time-dependent activation in endometrial cells which can be partly inhibited by blocking the transforming growth factor beta receptor II (TβRII).
Treatment of sporadic inclusion body myositis with bimagrumab.
New
Greenberg et al., Cambridge, United States. In Neurology, 07 Dec 2014
METHODS: We measured transforming growth factor β signaling by SMAD2/3 phosphorylation in muscle biopsies of 50 patients with neuromuscular disease (17 with sIBM).
Megakaryocytes maintain homeostatic quiescence and promote post-injury regeneration of hematopoietic stem cells.
New
Impact
Li et al., Kansas City, United States. In Nat Med, 30 Nov 2014
MK ablation led to reduced levels of biologically active TGF-β1 protein in the bone marrow and nuclear-localized phosphorylated SMAD2/3 (pSMAD2/3) in HSCs, suggesting that MKs maintain HSC quiescence through TGF-β-SMAD signaling.
The genetic basis of pulmonary arterial hypertension.
Review
New
Chung et al., New York City, United States. In Hum Genet, May 2014
CAV1 regulates SMAD2/3 phosphorylation, and mutations in CAV1 are a rare cause of PAH.
miR-27 Negatively Regulates Pluripotency-Associated Genes in Human Embryonal Carcinoma Cells.
New
Adjaye et al., Düsseldorf, Germany. In Plos One, Dec 2013
The ACTIVIN/NODAL axis (SMAD2/3) of the TGFß signalling pathway coupled with FGF signalling maintains self-renewal in these cells, whilst the BMP (SMAD1,5,8) axis promotes differentiation.
Prevention of Pulmonary Fibrosis via Trichostatin A (TSA) in Bleomycin Induced Rats.
New
Liu et al., Shanghai, China. In Sarcoidosis Vasc Diffuse Lung Dis, Dec 2013
To investigate the effects of non selective histone deacetylase inhibitors Trichostatin A ( TSA ) on HDAC2, p-SMAD2, HDAC2 mRNA, SMAD2mRNA in pulmonary fibrosis rats and investigate impossible mechanism.
Constitutively Active FOXO1 Diminishes Activin Induction of Fshb Transcription in Immortalized Gonadotropes.
New
Thackray et al., San Diego, United States. In Plos One, Dec 2013
In addition, our studies demonstrate that FOXO1 directly interacts with SMAD3/4 but not SMAD2 in a FOXO1 DBD-dependent manner.
De novo mutations in histone-modifying genes in congenital heart disease.
New
Impact
Lifton et al., New Haven, United States. In Nature, Jul 2013
There are also two de novo mutations in SMAD2, which regulates H3K27 methylation in the embryonic left-right organizer.
The kinase PKCα selectively upregulates interleukin-17A during Th17 cell immune responses.
New
Impact
Baier et al., Innsbruck, Austria. In Immunity, Feb 2013
We have shown that PKCα physically interacts and functionally cooperates with TGFβRI to promote robust SMAD2-3 activation.
TGF-β signaling in tissue fibrosis: redox controls, target genes and therapeutic opportunities.
Review
Higgins et al., Albany, United States. In Cell Signal, 2013
ROS generation in response to TGF-β1 stimulation is rapid and precedes PAI-1 induction; engagement of non-SMAD (e.g., EGFR, Src kinase, MAP kinases, p53) and SMAD2/3 pathways are both required for PAI-1 expression and are ROS-dependent.
Regulation of cumulus expansion and hyaluronan synthesis in porcine oocyte-cumulus complexes during in vitro maturation.
Review
Nagyova, Czech Republic. In Endocr Regul, 2012
Furthermore, SMAD2/3 signaling pathway is involved in the control of both cumulus expansion and steroidogenesis in porcine OCCs, since SMAD2/3 activation by GDF9/ TGFβ produced by oocyte and/or cumulus cells, significantly affects gonadotropin-induced HA and progesterone synthesis by porcine cumulus cells.
From tall to short: the role of TGFβ signaling in growth and its disorders.
Review
Cormier-Daire et al., Paris, France. In Am J Med Genet C Semin Med Genet, 2012
We found an increased level of active TGFβ in the fibroblast medium from patients with FBN1 or ADAMTSL2 mutations and an enhanced phosphorylated SMAD2 level, allowing us to conclude at an enhanced TGFβ signaling in GD and AD.
Smad2 decelerates re-epithelialization during gingival wound healing.
GeneRIF
Takashiba et al., Okayama, Japan. In J Dent Res, 2012
results indicated Smad2 has inhibitory effects in regulating keratinocyte migration during gingival wound healing. TGF-beta/Smad2 signaling mediating alteration of K16 expression must be tightly regulated during periodontal regeneration.
Post-translational regulation of TGF-β receptor and Smad signaling.
GeneRIF
Derynck et al., San Francisco, United States. In Febs Lett, 2012
TGF-beta family signaling through Smads is conceptually a simple and linear signaling pathway, driven by sequential phosphorylation, with type II receptors activating type I receptors, which in turn activate R-Smads [review]
Dynamics of TGF-β/Smad signaling.
GeneRIF
Liu et al., Freiburg, Germany. In Febs Lett, 2012
analysis of the dynamics of TGF-beta and Smad2/Smad3 signaling [review]
Smad2/Smad3 in endothelium is indispensable for vascular stability via S1PR1 and N-cadherin expressions.
GeneRIF
Kato et al., Tsukuba, Japan. In Blood, 2012
Smad2/3 signaling in ECs is indispensable for maintenance of vascular integrity via the fine-tuning of N-cadherin, VE-cadherin, and S1PR1 expressions in the vasculature.
TGF-β1 → SMAD/p53/USF2 → PAI-1 transcriptional axis in ureteral obstruction-induced renal fibrosis.
Review
Higgins et al., Albany, United States. In Cell Tissue Res, 2012
SMAD2/3, pp60(c-src), EGFR, and p53 activation are each increased in the obstructed kidney.
R-Smad competition controls activin receptor output in Drosophila.
GeneRIF
O'Connor et al., Minneapolis, United States. In Plos One, 2011
Data show that dSmad2 directly influences Baboon's phosphorylation of Mad.
The kinases MEKK2 and MEKK3 regulate transforming growth factor-β-mediated helper T cell differentiation.
Impact
Su et al., New Haven, United States. In Immunity, 2011
Map3k2(-/-)Map3k3(Lck-Cre/-) T cells exhibited impaired phosphorylation of SMAD2 and SMAD3 proteins at their linker regions, which negatively regulated the TGF-β responses in T cells.
Conserved and divergent roles of FGF signaling in mouse epiblast stem cells and human embryonic stem cells.
Impact
Schöler et al., Münster, Germany. In Cell Stem Cell, 2010
Our data suggest that FGF2 fails to cooperate with SMAD2/3 signaling in actively promoting EpiSC self-renewal through Nanog, in contrast to its role in hESCs.
More papers using Smad2 antibodies
Alpha 3 beta 1 adhesion to laminin-5 and invasin: critical and differential role of integrin residues clustered at the boundary between alpha 3 N-terminal repeats 2 and 3
Supplier
Chapman Harold A. et al., In The Journal of Cell Biology, 1998
... Secondary HRP-conjugated antibodies and Smad2/3 pAb were purchased from Santa Cruz Biotechnology, Inc ...
Krox-20 inhibits Jun-NH2-terminal kinase/c-Jun to control Schwann cell proliferation and death
Supplier
Jessen Kristjan R. et al., In The Journal of Cell Biology, 1998
... Antibody against c-Jun and SMAD2 were purchased from BD Biosciences.
Activin receptors: cellular signalling by receptor serine kinases
Supplier
Hamada Hiroshi et al., In The Journal of Cell Biology, 1995
... ten Dijke, Leiden University Medical Center, Leiden, Netherlands), rabbit monoclonal antibodies to p-Smad2 (Cell Signaling Technology), and Alexa Fluor ...
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