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SMAD family member 2

Smad2
The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: TGF-beta, Smad3, V1a, CAN, Smad4
Papers using Smad2 antibodies
Nuclear factor I-C links platelet-derived growth factor and transforming growth factor beta1 signaling to skin wound healing progression.
Supplier
Lee Sean Bong, In PLoS ONE, 2008
... Rabbit anti-p-Smad3 and total Smad2/3 antibodies were purchased from Cell Signaling Technology (Danvers, MA) ...
GADD34-PP1c recruited by Smad7 dephosphorylates TGF type I receptor.
Supplier
Goumans Marie Jose, In PLoS ONE, 2003
... The antibodies used were as follows: anti-phospho-Smad2 (Ser465/467) (138D4) and anti-Smad2 (L16D3) antibodies were purchased from Cell Signaling.
The emerging role of lysophosphatidic acid in cancer
Supplier
Quaranta Vito et al., In Journal of Oncology, 2002
... Polyclonal antibody (pAb) against phosphorylated Smad2 (Ser465/467), GAPDH, and monoclonal antibody (mAb) against Smad2/3 were purchased from Cell Signaling Technology (Danvers, MA), BD ...
Hmg-CoA reductase inhibitor modulates monocyte-endothelial cell interaction under physiological flow conditions in vitro: involvement of Rho GTPase-dependent mechanism
Supplier
Kim Jae Ho et al., In Experimental & Molecular Medicine, 2000
... Anti-phospho-Smad2 (Ser465/467) and anti-Smad2 antibodies were obtained from Cell Signaling Technology (Beverly, MA) ...
CHMP5 is essential for late endosome function and down-regulation of receptor signaling during mouse embryogenesis
Supplier
Ghosh Sankar et al., In The Journal of Cell Biology, 1999
... The antibodies used were anti–phospho-Erk1/2 (Cell Signaling Technology), anti–phospho-Smad2 (Cell Signaling Technology), anti-Smad4 (Santa Cruz ...
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Papers on Smad2
Aminoacyl-tRNA synthetase interacting multi-functional protein 1 attenuates liver fibrosis by inhibiting TGFβ signaling.
New
Park et al., South Korea. In Int J Oncol, 29 Feb 2016
The AIMP1 peptide induced phosphorylation of SMAD2 via ERK activation, and inhibited the nuclear translocation of SMAD, resulting in a reduction of the synthesis of type I collagen.
Ablation of neuropilin 1 from glioma-associated microglia and macrophages slows tumor progression.
New
Tsirka et al., Stony Brook, United States. In Oncotarget, 10 Feb 2016
Nrp1-deficient or EG00229-treated wild-type microglia exhibited a shift towards anti-tumorigenicity as evident by altered inflammatory marker profiles in vivo and decreased SMAD2/3 activation when conditioned in the presence of glioma-derived factors.
Activin B induces noncanonical SMAD1/5/8 signaling via BMP type I receptors in hepatocytes: evidence for a role in hepcidin induction by inflammation in male mice.
New
Babitt et al., Reggio nell'Emilia, Italy. In Endocrinology, 06 Feb 2016
Here, we show that low concentrations of Activin B, but not Activin A, stimulate prolonged SMAD1/5/8 signaling and hepcidin expression in liver cells to a similar degree as canonical SMAD2/3 signaling, and with similar or modestly reduced potency compared with BMP6.
The chondrocyte clock gene Bmal1 controls cartilage homeostasis and integrity.
New
Meng et al., In J Clin Invest, 04 Feb 2016
Loss of BMAL1 reduced the levels of phosphorylated SMAD2/3 (p-SMAD2/3) and NFATC2 and decreased expression of the major matrix-related genes Sox9, Acan, and Col2a1, but increased p-SMAD1/5 levels.
Early Regulation of Profibrotic Genes in Primary Human Cardiac Myocytes by Trypanosoma cruzi.
New
Nde et al., Nashville, United States. In Plos Negl Trop Dis, 31 Jan 2016
Furthermore, phosphorylated SMAD2/3 which induces a fibrogenic phenotype is also upregulated accompanied by an increased nuclear translocation of JunB.
Mesenchymal Cancer Cell-Stroma Crosstalk Promotes Niche Activation, Epithelial Reversion, and Metastatic Colonization.
New
Malanchi et al., London, United Kingdom. In Cell Rep, 22 Jan 2016
Subsequently, disseminated metastatic cells revert to an AXL-negative, more epithelial phenotype to proliferate and decrease the phosphorylation levels of TGF-β-dependent SMAD2-3 in favor of BMP/SMAD1-5 signaling.
Thrombospondin-1 Affects Bovine Luteal Function via Transforming Growth Factor-Beta1-Dependent and Independent Actions.
New
Meidan et al., In Biol Reprod, 09 Jan 2016
TGFB1 stimulated SMAD2 phosphorylation and SERPINE1 levels in dose- and time-dependent manners in luteal EC.
Adiponectin-derived active peptide ADP355 exerts anti-inflammatory and anti-fibrotic activities in thioacetamide-induced liver injury.
New
Zhang et al., Tianjin, China. In Sci Rep, 31 Dec 2015
These were associated with the inactivation of TGF-β1/SMAD2 signaling and the promotion of AMPK and STAT3 signaling.
Enhanced Expression of miR-425 Promotes Esophageal Squamous Cell Carcinoma Tumorigenesis by Targeting SMAD2.
New
Song et al., Beijing, China. In J Genet Genomics, 20 Dec 2015
Furthermore, we revealed the mechanism that miR-425 inhibited the expression of SMAD2 by targeting the second binding site in the 3'-untranslated region (3'-UTR) in ESCC.
Epigenetic Regulation of GDF2 Suppresses Anoikis in Ovarian and Breast Epithelia.
New
Mythreye et al., Durham, United States. In Neoplasia, Nov 2015
This activation is independent of cross talk with the SMAD2-transforming growth factor β pathway.
Myostatin is a direct regulator of osteoclast differentiation and its inhibition reduces inflammatory joint destruction in mice.
New
Impact
Pap et al., Münster, Germany. In Nat Med, Sep 2015
Myostatin strongly accelerates receptor activator of nuclear factor κB ligand (RANKL)-mediated osteoclast formation in vitro through transcription factor SMAD2-dependent regulation of nuclear factor of activated T-cells (NFATC1).
GDF11 Increases with Age and Inhibits Skeletal Muscle Regeneration.
New
Impact
Glass et al., Cambridge, United States. In Cell Metab, Aug 2015
Mechanistically, GDF11 and myostatin both induce SMAD2/3 phosphorylation, inhibit myoblast differentiation, and regulate identical downstream signaling.
β-Catenin Regulates Primitive Streak Induction through Collaborative Interactions with SMAD2/SMAD3 and OCT4.
New
Impact
Semb et al., Copenhagen, Denmark. In Cell Stem Cell, Jul 2015
β-catenin occupies regulatory regions in numerous PS and neural crest genes, and direct interactions between β-catenin and the Nodal effectors SMAD2/SMAD3 are required at these regions for PS gene activation.
Megakaryocytes maintain homeostatic quiescence and promote post-injury regeneration of hematopoietic stem cells.
Impact
Li et al., Kansas City, United States. In Nat Med, 2014
MK ablation led to reduced levels of biologically active TGF-β1 protein in the bone marrow and nuclear-localized phosphorylated SMAD2/3 (pSMAD2/3) in HSCs, suggesting that MKs maintain HSC quiescence through TGF-β-SMAD signaling.
De novo mutations in histone-modifying genes in congenital heart disease.
Impact
Lifton et al., New Haven, United States. In Nature, 2013
There are also two de novo mutations in SMAD2, which regulates H3K27 methylation in the embryonic left-right organizer.
Smad2 decelerates re-epithelialization during gingival wound healing.
GeneRIF
Takashiba et al., Okayama, Japan. In J Dent Res, 2012
results indicated Smad2 has inhibitory effects in regulating keratinocyte migration during gingival wound healing. TGF-beta/Smad2 signaling mediating alteration of K16 expression must be tightly regulated during periodontal regeneration.
Post-translational regulation of TGF-β receptor and Smad signaling.
GeneRIF
Derynck et al., San Francisco, United States. In Febs Lett, 2012
TGF-beta family signaling through Smads is conceptually a simple and linear signaling pathway, driven by sequential phosphorylation, with type II receptors activating type I receptors, which in turn activate R-Smads [review]
Dynamics of TGF-β/Smad signaling.
GeneRIF
Liu et al., Freiburg, Germany. In Febs Lett, 2012
analysis of the dynamics of TGF-beta and Smad2/Smad3 signaling [review]
Smad2/Smad3 in endothelium is indispensable for vascular stability via S1PR1 and N-cadherin expressions.
GeneRIF
Kato et al., Tsukuba, Japan. In Blood, 2012
Smad2/3 signaling in ECs is indispensable for maintenance of vascular integrity via the fine-tuning of N-cadherin, VE-cadherin, and S1PR1 expressions in the vasculature.
R-Smad competition controls activin receptor output in Drosophila.
GeneRIF
O'Connor et al., Minneapolis, United States. In Plos One, 2011
Data show that dSmad2 directly influences Baboon's phosphorylation of Mad.
More papers using Smad2 antibodies
Alpha 3 beta 1 adhesion to laminin-5 and invasin: critical and differential role of integrin residues clustered at the boundary between alpha 3 N-terminal repeats 2 and 3
Supplier
Chapman Harold A. et al., In The Journal of Cell Biology, 1998
... Secondary HRP-conjugated antibodies and Smad2/3 pAb were purchased from Santa Cruz Biotechnology, Inc ...
Krox-20 inhibits Jun-NH2-terminal kinase/c-Jun to control Schwann cell proliferation and death
Supplier
Jessen Kristjan R. et al., In The Journal of Cell Biology, 1998
... Antibody against c-Jun and SMAD2 were purchased from BD Biosciences.
Activin receptors: cellular signalling by receptor serine kinases
Supplier
Hamada Hiroshi et al., In The Journal of Cell Biology, 1995
... ten Dijke, Leiden University Medical Center, Leiden, Netherlands), rabbit monoclonal antibodies to p-Smad2 (Cell Signaling Technology), and Alexa Fluor ...
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