Regulation of mitochondrial membrane permeabilization by BCL-2 family proteins and caspases
In BMC Gastroenterology, 2003
... (TRAIL) (BD Pharmingen, Franklin Lake, NJ, USA); antibodies against Bcl-2, Bax, Fas, Fas ligand (FasL), Smac/Diablo, and heat shock protein (HSP) 60 (Santa Cruz Biotechnology, Santa Cruz, CA, USA); ...
Smac mimetics as IAP antagonists.
Frankfurt am Main, Germany. In Semin Cell Dev Biol, Mar 2015
Small-molecule inhibitors of IAP proteins mimicking the endogenous IAP antagonist Smac, called Smac mimetics, neutralize IAP proteins and thereby promote the induction of cell death.
Targeting IAP proteins for therapeutic intervention in cancer.
Frankfurt am Main, Germany. In Nat Rev Drug Discov, 2012
Among the therapeutic strategies that have been designed to target IAP proteins, the most widely used approach is based on mimicking the IAP-binding motif of second mitochondria-derived activator of caspase (SMAC), which functions as an endogenous IAP antagonist.
Mechanisms of TRAIL and gemcitabine induction of pancreatic cancer cell apoptosis.
Jinan, China. In Asian Pac J Cancer Prev, 2010
The levels of cellular apoptosis-associated proteins such as Smac/DIABLO, Cyto C, and the activated fragment of caspase-3 increased in pancreatic cancer cells, but the expression of XIAP was significantly decreased after 24 h treatment with the combination of TRAIL and gemcitabine.
XIAP discriminates between type I and type II FAS-induced apoptosis.
Melbourne, Australia. In Nature, 2009
Here we show that loss of XIAP (X-chromosome linked inhibitor of apoptosis protein) function by gene targeting or treatment with a second mitochondria-derived activator of caspases (SMAC, also called DIABLO; direct IAP-binding protein with low pI) mimetic drug in mice rendered hepatocytes and beta-cells independent of BID for FAS-induced apoptosis.