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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Diablo, IAP-binding mitochondrial protein

Smac, DIABLO
This gene encodes an inhibitor of apoptosis protein (IAP)-binding protein. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and it moderates the caspase inhibition of IAPs. Multiple polyadenylation sites have been found for this gene. Four alternatively spliced transcript variants have been described for this gene, with two of them encoding different isoforms and the other two probably not encoding a protein. [provided by RefSeq, Dec 2008] (from NCBI)
Papers using Smac antibodies
Pro-apoptotic Bid induces membrane perturbation by inserting selected lysolipids into the bilayer.
Supplier
Lightowlers Bob, In PLoS ONE, 2004
... from Cell Signaling (Danvers, MA, USA), against actin or tubulin from Sigma (Taufkirchen, GER), against Smac from MBL (Woburn, MA, USA).
Regulation of mitochondrial membrane permeabilization by BCL-2 family proteins and caspases
Supplier
Park Jung Han Yoon et al., In BMC Gastroenterology, 2003
... (TRAIL) (BD Pharmingen, Franklin Lake, NJ, USA); antibodies against Bcl-2, Bax, Fas, Fas ligand (FasL), Smac/Diablo, and heat shock protein (HSP) 60 (Santa Cruz Biotechnology, Santa Cruz, CA, USA); ...
IKKβ programs to turn on the GADD45α–MKK4–JNK apoptotic cascade specifically via p50 NF-κB in arsenite response
Supplier
Huang Chuanshu et al., In The Journal of Cell Biology, 2003
... and Smac antibodies were purchased from BD Biosciences.
XIAP-mediated Caspase Inhibition in Hodgkin's Lymphoma–derived B Cells
Supplier
Jürgensmeier Juliane M. et al., In The Journal of Experimental Medicine, 2000
... -terminal peptide, H-AVPIAQK-OH, (Calbiochem), Smac protein, or β-galactosidase (119-kD subunit) as a control using the Chariot protein transfection kit according to the instructions of the manufacturer (Active Motif).
Papers on Smac
Low circulating serum levels of second mitochondria-derived activator of caspase (Smac/DIABLO) in patients with bladder cancer.
GeneRIF
Bonavida et al., Takatsuki, Japan. In Int J Oncol, 2012
Overall, the findings suggest that measuring the levels of Smac/DIABLO in the serum may be considered a prognostic parameter in patients with bladder cancer.
[Overexpression of Smac gene enhanced chemotherapeutic sensitivity of esophageal cancer cell line Eca109 to cisplatin].
GeneRIF
Ren et al., Xi'an, China. In Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, 2012
Data show that the apoptosis rate of Eca109/Smac was significantly increased with the concentration of cispaltin increased.
NOXA-induced alterations in the Bax/Smac axis enhance sensitivity of ovarian cancer cells to cisplatin.
GeneRIF
Wei et al., Chengdu, China. In Plos One, 2011
these data suggest a new mechanism by which NOXA chemosensitized ovarian cancer cells to cisplatin by inducing alterations in the Bax/Smac axis.
[Regulation of wild type PTEN gene on Survivin, Xiap and Smac in chronic leukemia cells].
GeneRIF
Pan et al., Baoding, China. In Zhonghua Yi Xue Za Zhi, 2011
The over-expression of PTEN gene may inhibit the proliferation of K562 cells and promote cell apoptosis via the regulation of Survivin, Xiap and Smac genes.
Mechanisms of TRAIL and gemcitabine induction of pancreatic cancer cell apoptosis.
GeneRIF
Li et al., Jinan, China. In Asian Pac J Cancer Prev, 2010
The levels of cellular apoptosis-associated proteins such as Smac/DIABLO, Cyto C, and the activated fragment of caspase-3 increased in pancreatic cancer cells, but the expression of XIAP was significantly decreased after 24 h treatment with the combination of TRAIL and gemcitabine.
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