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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Diablo, IAP-binding mitochondrial protein

Smac, DIABLO
This gene encodes an inhibitor of apoptosis protein (IAP)-binding protein. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and it moderates the caspase inhibition of IAPs. Multiple polyadenylation sites have been found for this gene. Four alternatively spliced transcript variants have been described for this gene, with two of them encoding different isoforms and the other two probably not encoding a protein. [provided by RefSeq, Dec 2008] (from NCBI)
Top mentioned proteins: PrP, XIAP, caspase-3, bcl-2, Bax
Papers using Smac antibodies
Pro-apoptotic Bid induces membrane perturbation by inserting selected lysolipids into the bilayer.
Supplier
Lightowlers Bob, In PLoS ONE, 2004
... from Cell Signaling (Danvers, MA, USA), against actin or tubulin from Sigma (Taufkirchen, GER), against Smac from MBL (Woburn, MA, USA).
Regulation of mitochondrial membrane permeabilization by BCL-2 family proteins and caspases
Supplier
Park Jung Han Yoon et al., In BMC Gastroenterology, 2003
... (TRAIL) (BD Pharmingen, Franklin Lake, NJ, USA); antibodies against Bcl-2, Bax, Fas, Fas ligand (FasL), Smac/Diablo, and heat shock protein (HSP) 60 (Santa Cruz Biotechnology, Santa Cruz, CA, USA); ...
IKKβ programs to turn on the GADD45α–MKK4–JNK apoptotic cascade specifically via p50 NF-κB in arsenite response
Supplier
Huang Chuanshu et al., In The Journal of Cell Biology, 2003
... and Smac antibodies were purchased from BD Biosciences.
XIAP-mediated Caspase Inhibition in Hodgkin's Lymphoma–derived B Cells
Supplier
Jürgensmeier Juliane M. et al., In The Journal of Experimental Medicine, 2000
... -terminal peptide, H-AVPIAQK-OH, (Calbiochem), Smac protein, or β-galactosidase (119-kD subunit) as a control using the Chariot protein transfection kit according to the instructions of the manufacturer (Active Motif).
Papers on Smac
Cooperative TRAIL production mediates IFNα/Smac mimetic-induced cell death in TNFα-resistant solid cancer cells.
New
Fulda et al., Frankfurt am Main, Germany. In Oncotarget, Feb 2016
UNASSIGNED: Smac mimetics antagonize IAP proteins, which are highly expressed in several cancers.
Sensitization of acute lymphoblastic leukemia cells for LCL161-induced cell death by targeting redox homeostasis.
New
Fulda et al., Frankfurt am Main, Germany. In Biochem Pharmacol, Feb 2016
Erastin, buthionine sulfoximine (BSO) and Auranofin, sensitize ALL cells for cell death upon treatment with the Smac mimetic LCL161 that antagonizes Inhibitor of Apoptosis (IAP) proteins.
Suppressive Effect of Constructed shRNAs against Apollon Induces Apoptosis and Growth Inhibition of Hella Cell Line.
New
Kazemi et al., Tehrān, Iran. In Iran Biomed J, Feb 2016
In addition, shRNA1 effectively increased the mRNA level of Smac (as the antagonist of apollon), reduced the viability of HeLa cells and exhibited immunocytochemical apoptotic markers in this cell line.
Intrinsic and chemo-sensitizing activity of SMAC-mimetics on high-risk childhood acute lymphoblastic leukemia.
New
Debatin et al., Ulm, Germany. In Cell Death Dis, Dec 2015
SMAC-mimetics represent a targeted therapy approach to overcome apoptosis resistance in many tumors.
Inhibitor of apoptosis proteins as intracellular signaling intermediates.
Review
New
Duckett et al., Ann Arbor, United States. In Febs J, Nov 2015
Additionally, IAP-binding proteins, such as Smac and caspases, which have been described as having cell death-independent roles, may affect c-IAP activity in intracellular signaling.
Small molecule inhibitor of apoptosis proteins antagonists: a patent review.
Review
New
Yang et al., Waltham, United States. In Expert Opin Ther Pat, Jul 2015
Monovalent and bivalent Smac mimetics will be covered as well as two new developments in the field: IAP antagonists coupled to or merged with other targeted agents and new BIR2 selective IAP antagonists.
Smac mimetics as IAP antagonists.
Review
New
Fulda, Frankfurt am Main, Germany. In Semin Cell Dev Biol, Mar 2015
Small-molecule inhibitors of IAP proteins mimicking the endogenous IAP antagonist Smac, called Smac mimetics, neutralize IAP proteins and thereby promote the induction of cell death.
Kupfer-type immunological synapses in vivo: Raison D'être of SMAC.
Review
Barcia et al., Barcelona, Spain. In Immunol Cell Biol, 2015
These intimate contacts are characterized by the complex arrangement of molecules at the intercellular interface, which has been described as the supramolecular activation cluster (SMAC).
Effect of Smac in combination with cisplatin on esophageal cancer cell line ECA109.
Peng et al., Jinan, China. In Int J Clin Exp Med, 2014
OBJECTIVE: This study was to investigate inhibiting effect of structurally unique Second mitochondria-derived activator of caspase (Smac) in combination with cisplatin on esophageal cancer cell line ECA109.
Combinatorial cancer immunotherapy strategies with proapoptotic small-molecule IAP antagonists.
Review
Lacasse et al., Ottawa, Canada. In Int J Dev Biol, 2014
These antagonists are based on the structure of an endogenous cellular IAP inhibitor called Smac.
Smac mimetics and innate immune stimuli synergize to promote tumor death.
Impact
Korneluk et al., Ottawa, Canada. In Nat Biotechnol, 2014
Smac mimetic compounds (SMC), a class of drugs that sensitize cells to apoptosis by counteracting the activity of inhibitor of apoptosis (IAP) proteins, have proven safe in phase 1 clinical trials in cancer patients.
Non-chondritic sulphur isotope composition of the terrestrial mantle.
Impact
Moreira et al., Paris, France. In Nature, 2013
However, Earth's mantle has long been thought to be both homogeneous and chondritic for (34)S/(32)S, similar to Canyon Diablo troilite, as it is for most siderophile elements.
Low circulating serum levels of second mitochondria-derived activator of caspase (Smac/DIABLO) in patients with bladder cancer.
GeneRIF
Bonavida et al., Takatsuki, Japan. In Int J Oncol, 2012
Overall, the findings suggest that measuring the levels of Smac/DIABLO in the serum may be considered a prognostic parameter in patients with bladder cancer.
[Overexpression of Smac gene enhanced chemotherapeutic sensitivity of esophageal cancer cell line Eca109 to cisplatin].
GeneRIF
Ren et al., Xi'an, China. In Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, 2012
Data show that the apoptosis rate of Eca109/Smac was significantly increased with the concentration of cispaltin increased.
Targeting IAP proteins for therapeutic intervention in cancer.
Review
Impact
Vucic et al., Frankfurt am Main, Germany. In Nat Rev Drug Discov, 2012
Among the therapeutic strategies that have been designed to target IAP proteins, the most widely used approach is based on mimicking the IAP-binding motif of second mitochondria-derived activator of caspase (SMAC), which functions as an endogenous IAP antagonist.
NOXA-induced alterations in the Bax/Smac axis enhance sensitivity of ovarian cancer cells to cisplatin.
GeneRIF
Wei et al., Chengdu, China. In Plos One, 2011
these data suggest a new mechanism by which NOXA chemosensitized ovarian cancer cells to cisplatin by inducing alterations in the Bax/Smac axis.
[Regulation of wild type PTEN gene on Survivin, Xiap and Smac in chronic leukemia cells].
GeneRIF
Pan et al., Baoding, China. In Zhonghua Yi Xue Za Zhi, 2011
The over-expression of PTEN gene may inhibit the proliferation of K562 cells and promote cell apoptosis via the regulation of Survivin, Xiap and Smac genes.
Mechanisms of TRAIL and gemcitabine induction of pancreatic cancer cell apoptosis.
GeneRIF
Li et al., Jinan, China. In Asian Pac J Cancer Prev, 2010
The levels of cellular apoptosis-associated proteins such as Smac/DIABLO, Cyto C, and the activated fragment of caspase-3 increased in pancreatic cancer cells, but the expression of XIAP was significantly decreased after 24 h treatment with the combination of TRAIL and gemcitabine.
Division and apoptosis of E2f-deficient retinal progenitors.
Impact
Bremner et al., Toronto, Canada. In Nature, 2010
In flies this occurs through repression of hid (also called Wrinkled; Smac/Diablo in mammals).
XIAP discriminates between type I and type II FAS-induced apoptosis.
Impact
Kaufmann et al., Melbourne, Australia. In Nature, 2009
Here we show that loss of XIAP (X-chromosome linked inhibitor of apoptosis protein) function by gene targeting or treatment with a second mitochondria-derived activator of caspases (SMAC, also called DIABLO; direct IAP-binding protein with low pI) mimetic drug in mice rendered hepatocytes and beta-cells independent of BID for FAS-induced apoptosis.
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