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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Transgelin

SM22alpha, SM22, Calponin, ClC-1, transgelin, CLCN1, SCP1
The protein encoded by this gene is a transformation and shape-change sensitive actin cross-linking/gelling protein found in fibroblasts and smooth muscle. Its expression is down-regulated in many cell lines, and this down-regulation may be an early and sensitive marker for the onset of transformation. A functional role of this protein is unclear. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Actin, CAN, HAD, MUC4, fibrillin-1
Papers using SM22alpha antibodies
Direct labeling and visualization of blood vessels with lipophilic carbocyanine dye DiI.
Supplier
Anversa Piero, In PLoS ONE, 2007
... troponin I, desmin and vWF (Santa Cruz Biotechnology); smooth muscle actin (Sigma); Flk1 (Cell Signaling); sm22-α and Oct4, (Abcam); Alexa Fluor 488- or ...
Follicular dendritic cell sarcoma in the lymph nodes of the neck
Supplier
Adam Patrick et al., In Diagnostic Pathology, 2006
... CalponinDAKO ...
Papers on SM22alpha
AKT and JNK Signaling Pathways Increase the Metastatic Potential of Colorectal Cancer Cells by Altering Transgelin Expression.
New
Lin et al., Guangzhou, China. In Dig Dis Sci, Jan 2016
BACKGROUND: Transgelin (SM22) plays a crucial role in colorectal cancer (CRC) progression; nevertheless, its upstream regulatory mechanisms are poorly defined.
Identification and verification of transgelin-2 as a potential biomarker of tumor-derived lung-cancer endothelial cells by comparative proteomics.
New
Zhuo et al., Xiamen, China. In J Proteomics, Jan 2016
Upregulation of heat shock protein 60 (Hspd1) and transgelin-2 (Tagln2) was revealed in TECs, and by immunohistochemistry (IHC) in paired tissues from 30 consecutive lung cancer (LC) patients.
Regional specific modulation of the glycocalyx and smooth muscle cell contractile apparatus in conduit arteries of tail-suspended rats.
New
Deng et al., Beijing, China. In J Appl Physiol, Jan 2016
The relative mRNA levels of syndecan-2, 3, 4, glypican-1, smooth muscle protein 22 (SM22), smoothelin (SMTN), and calponin were enhanced to 1.40, 1.53, 1.70, 1.90, 2.93, 2.30, and 5.23-fold respectively in the common carotid artery of the TS rat.
A circulating permeability factor in focal segmental glomerulosclerosis: the hunt continues.
Review
New
Nangaku et al., Tokyo, Japan. In Clin Kidney J, Dec 2015
Although molecules such as cardiotrophin-like cytokine 1 (CLC-1) and anti-CD40 antibody have been proposed to be potential circulating permeability factors, a definitive factor remains to be discovered.
Differentiation of Human Induced-Pluripotent Stem Cells into Smooth-Muscle Cells: Two Novel Protocols.
New
Zhang et al., Birmingham, United States. In Plos One, Dec 2015
Assessments of cellular mRNA and/or protein levels indicated that SMA, myosin heavy chain II, collagen 1, calponin, transgelin, connexin 43, and vimentin expression in the SMCs obtained via the Contractile SMC protocol and in SMCs differentiated via a traditional protocol were similar, while SMCs produced via the Sythetic SMC protocol expressed less calponin, more collagen 1, and more connexin 43.
Immunohistochemical Expression of Calponin in Cutaneous Basal Cell Carcinoma.
New
Kullová et al., Martin, Slovakia. In Acta Dermatovenerol Croat, Dec 2015
Calponin is an actin filament-associated protein significantly involved in the regulation of the cellular motility.
Microcystic/Reticular Schwannoma of the Mandible First Case Report and Review of the Literature.
Review
New
Wu et al., Shanghai, China. In Medicine (baltimore), Nov 2015
Tumor cells were also positive for CD34, CD99, and NSE, but negative for CK, EMA, CK5/6, P63, Calponin, CD10, SMA, Desmin, GFAP, NF, Syn, and CgA.
Channelopathies of skeletal muscle excitability.
Review
New
Cannon, Los Angeles, United States. In Compr Physiol, Apr 2015
These familial disorders of muscle fiber excitability are "channelopathies" caused by mutations of a chloride channel (ClC-1), sodium channel (NaV1.4),
Pleiotropic effects of statins in hypercholesterolaemia: a prospective observational study using a lipoproteomic based approach.
New
Impact
Ng et al., Leicester, United Kingdom. In Lancet, Mar 2015
17 proteins were upregulated by statin therapy, including proteins concerned with cytoskeletal organisation (vinculin p<0·0001, tropomyosin α4 p=0·0108), antioxidative (peroxiredoxin 2 p=0·0092), and anti-inflammatory effects (transgelin-2 p=0·0071).
2D DIGE Does Not Reveal all: A Scotopic Report Suggests Differential Expression of a Single "Calponin Family Member" Protein for Tetany of Sphincters!
Review
Chaudhury, Little Rock, United States. In Front Med (lausanne), 2014
The study showed the differential expression of a single 23 kDa protein SM22, which was 1.87 fold, overexpressed in RSM in comparison to IAS.
ClC-1 chloride channels: state-of-the-art research and future challenges.
Review
Camerino et al., Bari, Italy. In Front Cell Neurosci, 2014
The voltage-dependent ClC-1 chloride channel belongs to the CLC channel/transporter family.
Intracellular β-nicotinamide adenine dinucleotide inhibits the skeletal muscle ClC-1 chloride channel.
GeneRIF
Parker et al., Australia. In J Biol Chem, 2012
a new biological role for NAD suggests that the main physiological relevance may be the exquisite sensitivity to intracellular pH that NAD(+) inhibition imparts to ClC-1 gating.
A new explanation for recessive myotonia congenita: exon deletions and duplications in CLCN1.
GeneRIF
Hanna et al., London, United Kingdom. In Neurology, 2012
copy number variation in CLCN1 may be an important cause of recessive myotonia congenita.
Transgelin is a marker of repopulating mesangial cells after injury and promotes their proliferation and migration.
GeneRIF
Hugo et al., Erlangen, Germany. In Lab Invest, 2012
Transgelin in the kidney is upregulated in repopulating mesangial cells in vivo and supports their migratory and proliferative repair response after injury.
Synaptonemal complex components persist at centromeres and are required for homologous centromere pairing in mouse spermatocytes.
GeneRIF
Pezza et al., Córdoba, Argentina. In Plos Genet, 2012
SYCP1 and SYCP3 act at the centromeres to promote the establishment and/or maintenance of centromere pairing and, by doing so, improve the segregation fidelity of mammalian meiotic chromosomes.
Depletion of the actin bundling protein SM22/transgelin increases actin dynamics and enhances the tumourigenic phenotypes of cells.
GeneRIF
Winder et al., Sheffield, United Kingdom. In Bmc Cell Biol, 2011
Depletion of SM22 could contribute to tumourigenic properties of cells. Reduction in SM22 would tend to promote cell survival when cells are under hypoxic stress, and may also contribute to increases in actin dynamics that favour metastatic potential.
Insig regulates HMG-CoA reductase by controlling enzyme phosphorylation in fission yeast.
Impact
Espenshade et al., Baltimore, United States. In Cell Metab, 2008
The fission yeast Schizosaccharomyces pombe encodes homologs of Insig, HMGR, SREBP, and Scap, called ins1(+), hmg1(+), sre1(+), and scp1(+).
The Cl-/H+ antiporter ClC-7 is the primary chloride permeation pathway in lysosomes.
Impact
Mindell et al., Bethesda, United States. In Nature, 2008
Several mammalian members of the CLC family have been characterized in detail; some (including ClC-0, ClC-1 and ClC-2) function as Cl--conducting ion channels, whereas others act as Cl-/H+antiporters (ClC-4 and ClC-5).
Rational design of a super core promoter that enhances gene expression.
Impact
Kadonaga et al., San Diego, United States. In Nat Methods, 2006
Here we describe the design and analysis of a potent core promoter, termed super core promoter 1 (SCP1), which directs high amounts of transcription by RNA polymerase II in metazoans.
Apoptosis of vascular smooth muscle cells induces features of plaque vulnerability in atherosclerosis.
Impact
Bennett et al., Cambridge, United Kingdom. In Nat Med, 2006
To study the direct consequences of VSMC apoptosis, we generated transgenic mice expressing the human diphtheria toxin receptor (hDTR, encoded by HBEGF) from a minimal Tagln (also known as SM22alpha) promoter.
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