Co-evolution of sphingomyelin and the ceramide transport protein CERT.
Tokyo, Japan. In Biochim Biophys Acta, 2014
In the biosynthesis of SM, ceramide, which is synthesized in the endoplasmic reticulum, is transported to the Golgi region by the ceramide transport protein CERT, probably in a non-vesicular manner, and is then converted to SM by SM synthase, which catalyzes the reaction of phosphocholine transfer from phosphatidylcholine (PtdCho) to ceramide.
Sphingolipids in lipid microdomains and obesity.
Sapporo, Japan. In Vitam Horm, 2012
Additionally, we recently reported that the function of lipid microdomains was dynamically regulated by the sphingomyelin synthase SMS2 on the plasma membrane and that SMS2-deficient mice exhibit resistance against high-fat diet-induced increases in body weight, glucose intolerance, and fatty liver.