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Sphingomyelin synthase 2

SM synthase, SMS2, Sphingomyelin synthase 2
Sphingomyelin, a major component of cell and Golgi membranes, is made by the transfer of phosphocholine from phosphatidylcholine onto ceramide, with diacylglycerol as a side product. The protein encoded by this gene is an enzyme that catalyzes this reaction primarily at the cell membrane. The synthesis is reversible, and this enzyme can catalyze the reaction in either direction. The encoded protein is required for cell growth. Three transcript variants encoding the same protein have been found for this gene. There is evidence for more variants, but the full-length nature of their transcripts has not been determined.[provided by RefSeq, Oct 2008] (from NCBI)
Top mentioned proteins: MOB, HAD, CAN, ACID, V1a
Papers on SM synthase
Comparative lipid analysis in the normal and cancerous organoids of MDCK cells.
New
Kiyokawa et al., Kanazawa, Japan. In J Biochem, Feb 2016
While the total SM is decreased more efficiently by SMS-1 knockdown than by SMS-2 knockdown, depletion of SMS-2, but not SMS-1, inhibits cyst growth.
Chinese hamster ovary-sphingomyelin synthase2 biospecific extraction and liquid chromatography with tandem mass spectrometry analysis for the prediction of bioactive components of Rhizoma Polygoni Cuspidati.
New
Liang et al., Shanghai, China. In J Sep Sci, Feb 2016
UNASSIGNED: A novel strategy for predicting bioactive components in traditional Chinese medicines using Chinese hamster ovary-sphingomyelin synthase2 (CHO-SMS2 ) cell biospecific extraction and high-performance liquid chromatography with diode array detection and tandem mass spectrometry analysis was proposed.
Prenatal alcohol exposure inducing the apoptosis of mossy cells in hippocampus of SMS2-/- mice.
New
Deng et al., Kaifeng, China. In Environ Toxicol Pharmacol, Nov 2015
In order to understand the mechanisms of alcohol-induced neuroapoptosis through the ceramide pathway, sphingomyelin synthase 2 knockout (SMS2-/-) mice were used to make the prenatal alcohol exposure model, and the role of ceramide regulation on alcohol-induced neuroapoptosis was studied in the offspring.
Analysis of lipid-composition changes in plasma membrane microdomains.
New
Okazaki et al., Kanazawa, Japan. In J Lipid Res, Aug 2015
This method revealed that glycosphingolipids composed the microdomains as a substitute for sphingomyelin (SM) in mouse embryonic fibroblasts (tMEFs) from an SM synthase 1/2 double KO (DKO) mouse.
PC-PLC/sphingomyelin synthase activity plays a central role in the development of myogenic tone in murine resistance arteries.
New
Wier et al., Baltimore, United States. In Am J Physiol Heart Circ Physiol, Jul 2015
Our results suggest that PI-PLC and IP3 are not required in maintaining myogenic tone, but DAG, produced by PC-PLC and/or SM synthase, is likely through multiple mechanisms to increase Ca(2+) entry and promote vasoconstriction.
Sphingomyelin metabolism is involved in the differentiation of MDCK cells induced by environmental hypertonicity.
New
Sterin-Speziale et al., Buenos Aires, Argentina. In J Lipid Res, Apr 2015
We found that SM synthesis mediated by SM synthase 1 is involved in hypertonicity-induced formation of mature AJs, necessary for correct epithelial cell differentiation.
Functional characterization of enzymes catalyzing ceramide phosphoethanolamine biosynthesis in mice.
New
Willecke et al., Bonn, Germany. In J Lipid Res, Apr 2015
Heterologous expression studies revealed that SM synthase (SMS)2 is a bifunctional enzyme producing both SM and CPE, whereas SMS-related protein (SMSr) serves as monofunctional CPE synthase.
All members in the sphingomyelin synthase gene family have ceramide phosphoethanolamine synthase activity.
New
Jiang et al., Foshan, China. In J Lipid Res, Mar 2015
Because SMS2 also has CPE synthase activity, we prepared Smsr/Sms2 double KO mice.
Sphingomyelin synthase 2, but not sphingomyelin synthase 1, is involved in HIV-1 envelope-mediated membrane fusion.
Yamashita et al., Saga, Japan. In J Biol Chem, 2014
We employed reconstituted cells as target cells that stably express Sms1 or Sms2 in Sms-deficient cells.
Sphingomyelin homeostasis is required to form functional enzymatic domains at the trans-Golgi network.
Malhotra et al., Barcelona, Spain. In J Cell Biol, 2014
In this paper, we show that disruption of SM homeostasis at the trans-Golgi network (TGN) by treatment of HeLa cells with d-ceramide-C6, which was converted together with phosphatidylcholine to short-chain SM and diacylglycerol by SM synthase, led to the segregation of Golgi-resident proteins from each other.
Differential effect of 2-hydroxyoleic acid enantiomers on protein (sphingomyelin synthase) and lipid (membrane) targets.
Escribá et al., Salerno, Italy. In Biochim Biophys Acta, 2014
It has been demonstrated that 2OHOA increases the sphingomyelin (SM) cell content via SM synthase (SGMS) activation.
Co-evolution of sphingomyelin and the ceramide transport protein CERT.
Review
Hanada, Tokyo, Japan. In Biochim Biophys Acta, 2014
In the biosynthesis of SM, ceramide, which is synthesized in the endoplasmic reticulum, is transported to the Golgi region by the ceramide transport protein CERT, probably in a non-vesicular manner, and is then converted to SM by SM synthase, which catalyzes the reaction of phosphocholine transfer from phosphatidylcholine (PtdCho) to ceramide.
Sphingolipids in lipid microdomains and obesity.
Review
Igarashi et al., Sapporo, Japan. In Vitam Horm, 2012
Additionally, we recently reported that the function of lipid microdomains was dynamically regulated by the sphingomyelin synthase SMS2 on the plasma membrane and that SMS2-deficient mice exhibit resistance against high-fat diet-induced increases in body weight, glucose intolerance, and fatty liver.
Sphingomyelin and sphingomyelin synthase (SMS) in the malignant transformation of glioma cells and in 2-hydroxyoleic acid therapy.
GeneRIF
Escribá et al., Palma, Spain. In Proc Natl Acad Sci U S A, 2012
Data indicate that the increased sphingomyelin mass was due to a rapid and highly specific activation of sphingomyelin synthases SMS1 and SMS2.
Adenovirus-mediated sphingomyelin synthase 2 increases atherosclerotic lesions in ApoE KO mice.
GeneRIF
Wu et al., Shanghai, China. In Lipids Health Dis, 2010
direct morphological evidence for the pro-atherogenic capabilities of sphingomyelin synthase 2
Sphingomyelin synthases regulate protein trafficking and secretion.
GeneRIF
Luberto et al., Charleston, United States. In Plos One, 2010
SMS1 and SMS2 are capable of regulating TGN-mediated protein trafficking and secretion
Sphingomyelin metabolism at the plasma membrane: implications for bioactive sphingolipids.
Review
Hannun et al., Charleston, United States. In Febs Lett, 2010
Consequently, the regulation of SM levels at the PM by enzymes such as sphingomyelinase (SMase) and SM synthase 2 (SMS2) can have profound effects - both on biophysical properties of the membrane, but also on cellular signaling.
Sphingomyelin synthase SMS2 displays dual activity as ceramide phosphoethanolamine synthase.
GeneRIF
Holthuis et al., Utrecht, Netherlands. In J Lipid Res, 2009
Data show that SMS2 acting as a bifunctional enzyme with both SM and CPE synthase activity.
Sphingomyelin synthase 2 is one of the determinants for plasma and liver sphingomyelin levels in mice.
GeneRIF
Jiang et al., New York City, United States. In Arterioscler Thromb Vasc Biol, 2009
Sphingomyelin synthase 2 is one of the determinants for plasma and liver sphingomyelin levels in mice.
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