Transport according to GARP: receiving retrograde cargo at the trans-Golgi network.
Bethesda, United States. In Trends Cell Biol, 2011
X-ray crystallography of the Vps53 and Vps54 subunits of GARP has revealed that this complex is structurally related to other tethering factors such as the exocyst, the conserved oligomeric Golgi (COG) and Dsl1 (dependence on SLY1-20) complexes, indicating that they all might work by a similar mechanism.
Understanding gibberellic acid signaling--are we there yet?
Tübingen, Germany. In Curr Opin Plant Biol, 2008
The current view is that GA binds to a soluble GID1 receptor, which interacts with the DELLA repressor proteins in a GA-dependent manner and thereby induces DELLA protein degradation via the E3 ubiquitin ligase SCF(GID2/SLY1).
Reversal of pathology in murine mucopolysaccharidosis type VII by somatic cell gene transfer.
Bar Harbor, United States. In Nature, 1993
An inherited deficiency of beta-glucuronidase in humans, mice and dogs causes mucopolysaccharidosis VII (Sly syndrome), a progressive degenerative disease that reduces lifespan (to an average of 5 months in mice) and results from lysosomal storage of undegraded glycosaminoglycans in the spleen, liver, kidney, cornea, brain and skeletal system.