Physical and functional association of c-Src and adhesion and degranulation-promoting adaptor protein (ADAP) inosteoclastogenesis in vitro.
In PLoS ONE, 2004
... Nck (recognizing Nck1 and Nck2, Becton Dickinson GmbH, Heidelberg, Germany, #610099), ADAP (BD, #610945), and SLP-76 (Santa Cruz Biotechnology Inc., Santa Cruz, USA, ...
Integrin signalling and function in immune cells.
Shanghai, China. In Immunology, 2012
This review discusses the key signalling complexes regulating integrin activation and function in both 'inside-out' and 'outside-in' pathways in T lymphocytes, including kinases, SLP-76, VAV1, ADAP, SKAP-55, RapL, RIAM, Rap1, Talin and Kindlin.
The osteoclast and its unique cytoskeleton.
Saint Louis, United States. In Ann N Y Acad Sci, 2011
When occupied, α(v) β(3) activates a canonical signaling complex consisting of c-Src, Syk, Dap12, Slp76, Vav 3, and Rac that permits the cell to spread and form actin rings.
Platelets: covert regulators of lymphatic development.
Philadelphia, United States. In Arterioscler Thromb Vasc Biol, 2010
Genetic experiments demonstrate that podoplanin, a transmembrane protein expressed on lymphatic endothelial cells, engages the platelet C-type lectin-like receptor 2 (CLEC-2) when exposed to blood, leading to SYK-SLP-76-dependent platelet activation.