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Lymphocyte cytosolic protein 2

SLP-76 was originally identified as a substrate of the ZAP-70 protein tyrosine kinase following T cell receptor (TCR) ligation in the leukemic T cell line Jurkat. The SLP-76 locus has been localized to human chromosome 5q33 and the gene structure has been partially characterized in mice. The human and murine cDNAs both encode 533 amino acid proteins that are 72% identical and comprised of three modular domains. The NH2-terminus contains an acidic region that includes a PEST domain and several tyrosine residues which are phosphorylated following TCR ligation. SLP-76 also contains a central proline-rich domain and a COOH-terminal SH2 domain. A number of additional proteins have been identified that associate with SLP-76 both constitutively and inducibly following receptor ligation, supporting the notion that SLP-76 functions as an adaptor or scaffold protein. Studies using SLP-76 deficient T cell lines or mice have provided strong evidence that SLP-76 plays a positive role in promoting T cell development and activation as well as mast cell and platelet function. [provided by RefSeq, Jul 2008] (from NCBI)
Papers using SLP-76 antibodies
Physical and functional association of c-Src and adhesion and degranulation-promoting adaptor protein (ADAP) inosteoclastogenesis in vitro.
Rénia Laurent, In PLoS ONE, 2004
... Nck (recognizing Nck1 and Nck2, Becton Dickinson GmbH, Heidelberg, Germany, #610099), ADAP (BD, #610945), and SLP-76 (Santa Cruz Biotechnology Inc., Santa Cruz, USA, ...
Fc∈RI-mediated recruitment of p53/56lyn to detergent-resistant membrane domains accompanies cellular signaling
Rivera Juan et al., In The Journal of Experimental Medicine, 1994
... Mouse mAbs to Vav, Rac1, LAT, phosphotyrosine (4G10), Grb2, SLP-76, and GFP were purchased from Upstate Biotechnology, Transduction Laboratories, and Clontech.
Papers on SLP-76
HIV-1 Nef limits communication between linker of activated T cells and SLP-76 to reduce formation of SLP-76-signaling microclusters following TCR stimulation.
Fackler et al., Heidelberg, Germany. In J Immunol, 2012
Nef employs a dual mechanism to disturb early TCR signaling by limiting the communication between LAT and SLP-76
Studying the dynamics of SLP-76, Nck, and Vav1 multimolecular complex formation in live human cells with triple-color FRET.
Barda-Saad et al., Ramat Gan, Israel. In Sci Signal, 2012
both T cell activation and the association between SLP-76 and Nck. After T cell receptor stimulation, SLP-76 was phosphorylated, which enabled the binding of Nck.
The adaptor protein SLP-76 regulates HIV-1 release and cell-to-cell transmission in T cells.
Ganju et al., Columbus, United States. In J Immunol, 2012
our studies demonstrate a novel role for the adaptor molecule SLP-76 in regulating HIV-1 infection in T cells
Crucial role of SLP-76 and ADAP for neutrophil recruitment in mouse kidney ischemia-reperfusion injury.
Zarbock et al., Münster, Germany. In J Exp Med, 2012
SLP-76 and ADAP are involved in E-selectin-mediated integrin activation and neutrophil recruitment to inflamed kidneys, which may underlie the development of life-threatening ischemia-reperfusion-induced acute kidney injury in humans.
Complementary phosphorylation sites in the adaptor protein SLP-76 promote synergistic activation of natural killer cells.
Long et al., Rockville, United States. In Sci Signal, 2011
Complementary phosphorylation sites in the adaptor protein SLP-76 promote synergistic activation of natural killer cells.
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