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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Stomatin

SLP-2, stomatin-like protein 2, Slp2-a, STOML2, exo-4
The protein encoded by this gene is a synaptotagmin-like protein (SLP) that belongs to a C2 domain-containing protein family. The SLP homology domain (SHD) of this protein has been shown to specifically bind the GTP-bound form of Ras-related protein Rab-27A (RAB27A). This protein plays a role in RAB27A-dependent vesicle trafficking and controls melanosome distribution in the cell periphery. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jun 2009] (from NCBI)
Top mentioned proteins: CAN, Slp1, HAD, ACID, fibrillin-1
Papers on SLP-2
Stomatin-like protein 2 overexpression in papillary thyroid carcinoma is significantly associated with high-risk clinicopathological parameters and BRAFV600E mutation.
New
Cvejic et al., Belgrade, Serbia. In Apmis, Feb 2016
UNASSIGNED: Stomatin-like protein 2 (SLP-2), a member of the stomatin protein family, has emerged as a potential molecular hallmark of tumor progression in several human malignancies.
Alteration of SLP2-like immunolabeling in mitochondria signifies early cellular damage in developing and adult mouse brain.
New
Rakic et al., New Haven, United States. In Eur J Neurosci, Jan 2016
The method is based on our recent finding that antibodies directed against the cannabinoid type 1 receptor (CB1 ) also bind the mitochondrial stomatin-like protein 2 (SLP2) that belongs to an inner mitochondrial membrane protein complex.
Gene Expression Profiling of Desmoid Tumors by cDNA Microarrays and Correlation with Progression-Free Survival.
New
Chibon et al., Marseille, France. In Clin Cancer Res, Oct 2015
Finally, the top two genes downregulated in no-recurrence were FECH and STOML2 and the top gene upregulated in no-recurrence was TRIP6.
Proteomic Analysis of ABCA1-Null Macrophages Reveals a Role for Stomatin-Like Protein-2 in Raft Composition and Toll-Like Receptor Signaling.
New
Fessler et al., Winston-Salem, United States. In Mol Cell Proteomics, Jul 2015
Stomatin-like protein (SLP)-2, a member of the stomatin-prohibitin-flotillin-HflK/C family of membrane scaffolding proteins, was robustly and specifically increased in Abca1(-/-) rafts.
Slp2-a inactivates ezrin by recruiting protein phosphatase 1 to the plasma membrane.
New
Fukuda et al., Sendai, Japan. In Biochem Biophys Res Commun, Jun 2015
Synaptotagmin-like protein 2-a (Slp2-a) was originally described as a membrane trafficking protein that consists of a Slp homology domain (SHD), a linker domain, and tandem C2 domains (named the C2A domain and C2B domain).
Stomatin-like protein 2 is required for in vivo mitochondrial respiratory chain supercomplex formation and optimal cell function.
New
Madrenas et al., Montréal, Canada. In Mol Cell Biol, May 2015
Stomatin-like protein 2 (SLP-2) is a mainly mitochondrial protein that is widely expressed and is highly conserved across evolution.
miRNA-1207-5p is associated with cancer progression by targeting stomatin-like protein 2 in esophageal carcinoma.
New
Zhao et al., Zhengzhou, China. In Int J Oncol, May 2015
Stomatin-like protein 2 (STOML-2) was predicted to be a potential target of miR‑1207-5p by bioinformatics analysis and this was confirmed by luciferase assay and western blotting.
Stomatin-like protein 2 is overexpressed in epithelial ovarian cancer and predicts poor patient survival.
Li et al., Xinhui, China. In Bmc Cancer, 2014
BACKGROUND: Stomatin-like protein 2 (SLP-2, also known as STOML2) is a stomatin homologue of uncertain function.
Functional analysis of Rab27A and its effector Slp2-a in renal epithelial cells.
Fukuda et al., Sendai, Japan. In Methods Mol Biol, 2014
In a recent study we used Madin-Darby canine kidney (MDCK) II cells as a model of polarized cells and concluded from the results that Rab27A and its effector synaptotagmin-like protein 2-a (Slp2-a) regulate apical transport of Rab27-bearing vesicles in polarized epithelial cells.
Stomatin-like protein 2 expression is associated with clinical survival in patients with cervical cancer.
Zhang et al., Chenzhou, China. In Int J Clin Exp Pathol, 2014
AIMS: To investigate the prognostic role of stomatin-like protein 2 (STOML2) in cervical cancer.
Mitochondrial Band-7 family proteins: scaffolds for respiratory chain assembly?
Review
Sweetlove et al., Oxford, United Kingdom. In Front Plant Sci, 2013
Some members, such as prohibitins (PHB) and human stomatin-like protein 2 (HsSLP2), localize to the mitochondrial inner membrane where they function in cristae formation and hyperfusion.
Synaptotagmin-like proteins control the formation of a single apical membrane domain in epithelial cells.
Impact
Martín-Belmonte et al., Madrid, Spain. In Nat Cell Biol, 2012
Here, from a functional screen for genes required for three-dimensional epithelial architecture, we identify key roles for synaptotagmin-like proteins 2-a and 4-a (Slp2-a/4-a) in the generation of a single apical surface per cell.
Identification and validation of novel serum markers for early diagnosis of endometriosis.
GeneRIF
Khole et al., Mumbai, India. In Hum Reprod, 2012
investigation of biomarkers for early diagnosis of endometriosis: Data suggest that SLP2, tropomyosin 3, and tropomodulin 3 are autoantigens present in blood of women with endometriosis; immunodominant epitopes were identified.
SLP-2 overexpression could serve as a prognostic factor in node positive and HER2 negative breast cancer.
GeneRIF
Sun et al., Tianjin, China. In Pathology, 2011
SLP-2 and HER2/neu can play a role in lymph node/distant metastases of breast cancers
Mitochondrial and plasma membrane pools of stomatin-like protein 2 coalesce at the immunological synapse during T cell activation.
GeneRIF
Madrenas et al., London, Canada. In Plos One, 2011
SLP-2 facilitates the compartmentalization not only of mitochondrial membranes but also of the plasma membrane into functional microdomains.
Stomatin-like protein 2 binds cardiolipin and regulates mitochondrial biogenesis and function.
GeneRIF
Madrenas et al., London, Canada. In Mol Cell Biol, 2011
We propose that the function of SLP-2 is to recruit prohibitins to cardiolipin to form cardiolipin-enriched microdomains in which electron transport complexes are optimally assembled.
[Expression of SLP-2 protein in esophageal squamous cell carcinoma is associated with cancer invasion].
GeneRIF
Sun et al., Tianjin, China. In Zhonghua Zhong Liu Za Zhi, 2010
SLP2 may play an important role in tumorigenesis of esophageal squamous cell carcinoma.
Griscelli syndrome: a model system to study vesicular trafficking.
Review
Lambert et al., Gent, Belgium. In Pigment Cell Melanoma Res, 2009
As the small GTPase Rab27a is able to interact with multiple effectors, including Slp2-a and Myrip, we report on their presumed role in melanosome transport.
Physiological factors that regulate skin pigmentation.
Review
Hearing et al., Nagoya, Japan. In Biofactors, 2009
Microtubules, dynein, kinesin, actin filaments, Rab27a, melanophilin, myosin Va, and Slp2-a are involved in melanosome transport.
Rab27A-binding protein Slp2-a is required for peripheral melanosome distribution and elongated cell shape in melanocytes.
Impact
GeneRIF
Fukuda et al., Wako, Japan. In Nat Cell Biol, 2004
Loss of Slp2-a protein also induced a change in melanocyte morphology, from their normal elongated shape to a more rounded shape, which depended on the phospholipid-binding activity of Slp2-a
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