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SLIT and NTRK-like family, member 1

SLITRK1, Slitrk
This intronless gene encodes a member of the SLITRK protein family. These proteins are integral membrane proteins that are characterized by two N-terminal leucine-rich repeat (LRR) domains and a C-terminal region that shares homology with trk neurotrophin receptors. However, the protein encoded by this gene lacks the region of homology to neurotrophin receptors. The protein is thought to be involved in neurite outgrowth. Mutations in this gene may be associated with Tourette syndrome.[provided by RefSeq, Mar 2010] (from NCBI)
Top mentioned proteins: trkA, Slitrk6, CAN, Tic, HAD
Papers on SLITRK1
Analysis of SLITRK1 in Japanese patients with Tourette syndrome using a next-generation sequencer.
New
Kano et al., Tokyo, Japan. In Psychiatr Genet, Dec 2015
The SLITRK1 (Slit and Trk-like 1) gene has been suggested to be a promising candidate for Tourette syndrome (TS) since the first report that identified its two rare variants adjacent to the chromosome inversion in a TS child with inv(13) (q31.1;q33.1).
Slitrk5 Mediates BDNF-Dependent TrkB Receptor Trafficking and Signaling.
New
Lee et al., New York City, United States. In Dev Cell, Jul 2015
All Slitrk isotypes are highly expressed in the CNS, where they mediate neurite outgrowth, synaptogenesis, and neuronal survival.
Association study of the SLITRK5 gene and Tourette syndrome.
New
Barr et al., Toronto, Canada. In Psychiatr Genet, Feb 2015
SLITRK5, one of a family of six SLITRK genes, has been suggested as a possible candidate gene contributing towards obsessive-compulsive disorder on the basis of the mouse knockout model that shows excessive grooming behaviours that are alleviated with fluoxetine.
Comparison of the transcriptomes of mouse skin derived precursors (SKPs) and SKP-derived fibroblasts (SFBs) by RNA-Seq.
Li et al., Chengdu, China. In Plos One, 2014
The most significantly up-regulated genes Wnt4, Wisp2 and Tsp-1 and down-regulated genes Slitrk1, Klk6, Agtr2, Ivl, Msx1, IL15, Atp6v0d2, Kcne1l and Thbs4 may play important roles in the differentiation of SKPs into fibroblasts.
Slitrk gene duplication and expression in the developing zebrafish nervous system.
Lom et al., United States. In Dev Dyn, 2014
BACKGROUND: The Slitrk family of leucine-rich repeat (LRR) transmembrane proteins bears structural similarity to the Slits and the Trk receptor families, which exert well-established roles in directing nervous system development.
Structural basis for LAR-RPTP/Slitrk complex-mediated synaptic adhesion.
Kim et al., Seoul, South Korea. In Nat Commun, 2013
Subsequent crystallographic and structure-guided functional analyses reveal that the splicing inserts in LAR-RPTPs are key molecular determinants for Slitrk binding and synapse formation.
Porcine SLITRK1: Molecular cloning and characterization.
Bendixen et al., Århus, Denmark. In Febs Open Bio, 2013
The membrane protein SLITRK1 functions as a developmentally regulated stimulator of neurite outgrowth and variants in this gene have been implicated in Tourette syndrome.
The genetic basis of Gilles de la Tourette Syndrome.
Review
Paschou, Greece. In Neurosci Biobehav Rev, 2013
The study of chromosomal aberrations in TS etiology has implicated multiple genes, with SLITRK1 being the most prominent example.
Sequence analysis of SLITRK1 for var321 in Danish patients with Tourette syndrome and review of the literature.
Review
Tümer et al., Glostrup, Denmark. In Psychiatr Genet, 2013
One of the few genes that has been linked to TS is the SLITRK1 (Slit and Trk-like 1) gene, where four variations have been suggested as possible disease-associated changes.
Characterization of SLITRK1 variation in obsessive-compulsive disorder.
Grice et al., Miami, United States. In Plos One, 2012
The SLITRK1 gene encodes a developmentally regulated stimulator of neurite outgrowth and previous studies have implicated rare variants in this gene in disorders in the OC spectrum, specifically Tourette syndrome (TS) and trichotillomania (TTM).
[Searching for Tourette's syndrome gene. Part 2. Patient's genome variability].
Review
Rajewski et al., Poznań, Poland. In Postepy Hig Med Dosw (online), 2011
Moreover, pathogenic mutations responsible for GTS were found in the SLITRK1 and the L-histidine decarboxylase (HDC) genes.
Mutant human embryonic stem cells reveal neurite and synapse formation defects in type 1 myotonic dystrophy.
Impact
GeneRIF
Martinat et al., Rouen, France. In Cell Stem Cell, 2011
DM1 motoneuron/muscle cell cocultures showed alterations that are consistent with the known role of SLITRK genes in neurite outgrowth, neuritogenesis, and synaptogenesis; functional defects can be directly attributed to SLITRK misexpression.
Slitrks as emerging candidate genes involved in neuropsychiatric disorders.
Review
Lee et al., New York City, United States. In Trends Neurosci, 2011
Six family members exist (Slitrk1-6) and all are highly expressed in the central nervous system (CNS).
Additional support for the association of SLITRK1 var321 and Tourette syndrome.
GeneRIF
State et al., In Mol Psychiatry, 2010
The study of this study support that SLITRK1 var321 is association to Tourette syndrome.
Slitrk1-deficient mice display elevated anxiety-like behavior and noradrenergic abnormalities.
GeneRIF
Aruga et al., Wako, Japan. In Mol Psychiatry, 2010
These results lead us to conclude that noradrenergic mechanisms are involved in the behavioral abnormalities of Slitrk1-deficient mice. Elevated anxiety due to Slitrk1 dysfunction may contribute to the pathogenesis of neuropsychiatric diseases
Tourette Disorder Overview
Review
State et al., Seattle, United States. In Unknown Journal, 2009
SLITRK1 is one of several genes thought to be associated with TD; however, molecular genetic testing of SLITRK1 is of little or no clinical relevance based on current knowledge.
Developmentally regulated and evolutionarily conserved expression of SLITRK1 in brain circuits implicated in Tourette syndrome.
GeneRIF
Louvi et al., New Haven, United States. In J Comp Neurol, 2009
Data show that the expression of SLITRK1 is dynamic and specifically associated with the circuits most commonly implicated in TS and related disorders, suggesting that SLITRK1 contributes to the development of corticostriatal-thalamocortical circuits.
Sequence analysis of the complete SLITRK1 gene in Austrian patients with Tourette's disorder.
GeneRIF
Stamenkovic et al., Vienna, Austria. In Psychiatr Genet, 2008
results provide no evidence for SLITRK1 playing a major role in Tourette disease
Sequence variants in SLITRK1 are associated with Tourette's syndrome.
Impact
GeneRIF
State et al., New Haven, United States. In Science, 2005
findings support the association of rare SLITRK1 sequence variants with Tourette's syndrome
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