Association study of the SLITRK5 gene and Tourette syndrome.
Toronto, Canada. In Psychiatr Genet, Feb 2015
SLITRK5, one of a family of six SLITRK genes, has been suggested as a possible candidate gene contributing towards obsessive-compulsive disorder on the basis of the mouse knockout model that shows excessive grooming behaviours that are alleviated with fluoxetine.
Comparison of the transcriptomes of mouse skin derived precursors (SKPs) and SKP-derived fibroblasts (SFBs) by RNA-Seq.
Chengdu, China. In Plos One, 2014
The most significantly up-regulated genes Wnt4, Wisp2 and Tsp-1 and down-regulated genes Slitrk1, Klk6, Agtr2, Ivl, Msx1, IL15, Atp6v0d2, Kcne1l and Thbs4 may play important roles in the differentiation of SKPs into fibroblasts.
Characterization of SLITRK1 variation in obsessive-compulsive disorder.
Miami, United States. In Plos One, 2012
The SLITRK1 gene encodes a developmentally regulated stimulator of neurite outgrowth and previous studies have implicated rare variants in this gene in disorders in the OC spectrum, specifically Tourette syndrome (TS) and trichotillomania (TTM).
Tourette Disorder Overview
Seattle, United States. In Unknown Journal, 2009
SLITRK1 is one of several genes thought to be associated with TD; however, molecular genetic testing of SLITRK1 is of little or no clinical relevance based on current knowledge.