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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Slit homolog 2

Slit2, Slit1, Slit3
acts as a ligand for glypican-1, a heparan sulfate proteoglycan; may play a role in neurogenesis and midline development [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: Robo1, Robo2, CAN, Midline, HAD
Papers on Slit2
The relationship between prenatal exposure to BP-3 and Hirschsprung's disease.
Xia et al., Nanjing, China. In Chemosphere, Feb 2016
What's more, we discovered dose-response relationship between RET expression and BP-3 exposure dose, and miR-218 and some other genes involved in SLIT2/ROBO1-miR-218-RET/PLAG1 pathway were also related to BP-3 exposure.
The effects of house dust mite sublingual immunotherapy in patients with allergic rhinitis according to duration.
Xu et al., Guangzhou, China. In Int Forum Allergy Rhinol, Jan 2016
Patients in the SLIT group were further divided into SLIT1, SLIT2, and SLIT3 subgroups.
Mammary Stem Cell Self-Renewal Is Regulated by Slit2/Robo1 Signaling through SNAI1 and mINSC.
Hinck et al., Santa Cruz, United States. In Cell Rep, Nov 2015
We demonstrate that SLIT2/ROBO1 signaling regulates the choice between self-renewing asymmetric cell divisions (ACDs) and expansive symmetric cell divisions (SCDs) by governing Inscuteable (mInsc), a key member of the spindle orientation machinery, through the transcription factor Snail (SNAI1).
Identification of polymorphisms associated with production traits on chicken (Gallus gallus) chromosome 4.
Coutinho et al., Piracicaba, Brazil. In Genet Mol Res, 2014
Three positional candidate genes were studied: KLF3 (Krüeppel-like factor 3), SLIT2 (Slit homolog 2), and PPARGC1A (peroxisome proliferator-activated receptor gamma, coactivator 1 alpha).
Comprehensive DNA Methylation Analysis Reveals a Common Ten-Gene Methylation Signature in Colorectal Adenomas and Carcinomas.
Molnár et al., Budapest, Hungary. In Plos One, 2014
More than 85% of tumor samples showed hypermethylation in 10 genes (SFRP1, SST, BNC1, MAL, SLIT2, SFRP2, SLIT3, ALDH1A3, TMEFF2, WIF1), whereas the frequency of examined mutations were below 25%.
Involvement of Slit-Robo signaling in the development of the posterior commissure and concomitant swimming behavior in Xenopus laevis.
Murakami et al., Japan. In Zoological Lett, 2014
RESULTS: Here, we report the developmentally regulated expression pattern of axon-guidance molecules Slit2 ligand and Robo2 receptor in Xenopus laevis and show that treatment of X. laevis larvae with a slit2- or robo2-morpholino resulted in abnormal swimming behavior.
Whole-exome and targeted sequencing identify ROBO1 and ROBO2 mutations as progression-related drivers in myelodysplastic syndromes.
Li et al., Shanghai, China. In Nat Commun, 2014
However, this effect was lost in ROBO mutants and ROBO-SLIT2 signalling is impaired.
Role of ROBO4 signalling in developmental and pathological angiogenesis.
Narayan et al., Benares, India. In Biomed Res Int, 2013
Although SLIT2 has been shown to interact with ROBO4 as ligand, it remains an open question whether this protein is the physiologic partner of ROBO4.
Responding to R-spondin: slit2 potentiates intestinal regeneration.
Sansom et al., Australia. In Cell Stem Cell, 2013
Gastrointestinal toxicity of chemoradiotherapy treatment in late-stage cancer patients limits tolerable doses and effectiveness of treatments.
Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer.
Thomas et al., Köln, Germany. In Nat Genet, 2012
Furthermore, we observed mutations in PTEN, SLIT2 and EPHA7, as well as focal amplifications of the FGFR1 tyrosine kinase gene.
Morphological phenotypes of olfactory ensheathing cells display different migratory responses upon Slit-2.
Huang et al., Wenzhou, China. In Exp Cell Res, 2012
a Slit-2 gradient induced the collapse of the plasma membrane, and inhibited migration of flattened olfactory ensheathing glial cells
Robo2--slit and Dcc--netrin1 coordinate neuron axonal pathfinding within the embryonic axon tracts.
Peng et al., Shanghai, China. In J Neurosci, 2012
Slit3 (and slit-2) coordinate neuron axonal pathfinding within the embryonic axon tracts along with Robo2 and Dcc-Netrin1.
Slit2 and Robo3 modulate the migration of GnRH-secreting neurons.
Parnavelas et al., London, United Kingdom. In Development, 2012
Data show that the gooseberry/gooseberry-neuro (gsb/gsb-n) transcription factor genes act to specify MP3 cell fate.
Control of human hematopoietic stem/progenitor cell migration by the extracellular matrix protein Slit3.
van Hennik et al., Amsterdam, Netherlands. In Lab Invest, 2012
Slit3 treatment increased the in vivo homing efficiency of CD34 HSPCs to the BM in NOD/SCID mice, whereas Slit3-exposed HSPC migration in vitro was inhibited. Results support a role for Slit3 in human HSPC migration in vitro and homing in vivo.
Spontaneous activity regulates Robo1 transcription to mediate a switch in thalamocortical axon growth.
López-Bendito et al., Alacant, Spain. In Nat Neurosci, 2012
Disruption of either the Robo1 or Slit1 genes accelerates progression of thalamocortical axons in vivo.
A theoretical molecular network for dyslexia: integrating available genetic findings.
Franke et al., Nijmegen, Netherlands. In Mol Psychiatry, 2011
Based on this, we also propose three novel dyslexia candidate genes (SLIT2, HMGB1 and VAPA) from known linkage regions, and we discuss the possible involvement of genes emerging from the two reported genome-wide association studies for reading impairment-related phenotypes in the identified network.
Axon guidance and synaptic maintenance: preclinical markers for neurodegenerative disease and therapeutics.
Isacson et al., Belmont, United States. In Trends Neurosci, 2009
The axon-guidance-pathway genes DCC, EPHB1, NTNG1, SEMA5A and SLIT3 were represented by SNPs predicting PD outcomes.
Long-range Ca2+ signaling from growth cone to soma mediates reversal of neuronal migration induced by slit-2.
Poo et al., Shanghai, China. In Cell, 2007
long-range Ca(2+) signaling coordinates the Slit-2-induced changes in motility at two distant parts of migrating neurons by regulating RhoA distribution
Slits and their receptors.
Chédotal, Paris, France. In Adv Exp Med Biol, 2006
Alternative spliced transcripts have been reported for Drosophila Slit2, human Slit2 and Slit3, and Slit1.
Role of Slit proteins in the vertebrate brain.
Chédotal et al., Paris, France. In J Physiol Paris, 2002
Three distinct slit genes (slit1, slit2 and slit3) and three distinct robo genes (robo1, robo2 and rig-1) have been cloned in mammals.
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