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Solute carrier family 41, member 2

SLC41A2, solute carrier family 41 member 2
Top mentioned proteins: TRPM7, melastatin, TRPM6, HAD, V1a
Papers on SLC41A2
Gene expression profiling of DMU-212-induced apoptosis and anti-angiogenesis in vascular endothelial cells.
New
Zhang et al., Zhengzhou, China. In Pharm Biol, Nov 2015
RESULTS AND CONCLUSION: DMU-212 was found to regulate a diverse range of genes, including cytokines (IL8, selectin E, MPZL2, EGR1, CCL20, ITGB8, CXCL1, VCAM1, KITLG, and AREG), transport proteins (TRPC4, SLC41A2, SLC17A5, and CREB5), metabolism (CYP1B1, CYP1A1, PDK4, CSNK1G1, MVK, TCEB3C, and CDKN3), enzymes (RAB23, SPHK1, CHSY3, PLAU, PLA2G4C, and MMP10), and genes involved in signal transduction (TMEM217, DUSP8, and SPRY4), chromosome organization (HIST1H2BH and GEM), cell migration and angiogenesis (ERRFI1, HBEGF, and NEDD9), and apoptosis (TNFSF15, TNFRSF9, CD274, BCL2L11, BIRC3, TNFAIP3, and TIFA), as well as other genes with unknown function (PGM5P2, SNORD1142, LOC151760, KRTAP5-2, C1orf110, SNORA14A, MIR31, C2CD4B, SCARNA4, C2orf66, SC4MOL, LOC644714, and LOC283392).
Genetic variations in magnesium-related ion channels may affect diabetes risk among African American and Hispanic American women.
New
Liu et al., Boston, United States. In J Nutr, Mar 2015
Among HA women, several variants were significantly associated with T2D risk, including rs10861279 in solute carrier family 41 (anion exchanger), member 2 (SLC41A2) (OR: 0.54; FDR-adjusted P = 0.04), rs7174119 in nonimprinted in Prader-Willi/Angelman syndrome 1 (NIPA1) (OR: 1.27; FDR-adjusted P = 0.04), and 2 SNPs in mitochondrial RNA splicing 2 (MRS2) (rs7738943: OR = 1.55,
SLC41 transporters--molecular identification and functional role.
Review
Kolisek et al., Germany. In Curr Top Membr, 2013
There is only very limited knowledge on the molecular biology and exact functions of SLC41A2 and SLC41A3.
The role of Mg2+ in immune cells.
Review
Schmitz et al., Denver, United States. In Immunol Res, 2013
The molecular identification of multiple Mg(2+) transporters (Acdp2, MagT1, Mrs2, Paracellin-1, SLC41A1, SLC41A2, TRPM6 and TRPM7) and their biophysical characterization in recent years has improved our understanding of Mg(2+) homeostasis regulation and has provided a basis for investigating the role of Mg(2+) in the immune system.
Solute Carrier Family SLC41, what do we really know about it?
Kolisek et al., Honolulu, United States. In Wiley Interdiscip Rev Membr Transp Signal, 2012
Little is known about the exact function of SLC41A2 and SLC41A3, although, these proteins have also been linked to Mg(2+) transport in human (animal) cells.
A key role for Mg(2+) in TRPM7's control of ROS levels during cell stress.
Runnels et al., United States. In Biochem J, 2012
Re-expression of TRPM7 or of a kinase-inactive mutant of TRPM7 in TRPM7-knockdown cells increased cellular Mg(2+) and ROS levels, as did expression of the Mg(2+) transporter SLC41A2 (solute carrier family 41 member 2).
Whole-genome studies identify solute carrier transporters in cellular susceptibility to paclitaxel.
Dolan et al., Chicago, United States. In Pharmacogenet Genomics, 2012
A subset of SLC genes, namely SLC31A2, SLC43A1, SLC35A5, and SLC41A2, was associated with paclitaxel sensitivity and had regulating single nucleotide polymorphisms that were also associated with paclitaxel-induced cytotoxicity.
The B. subtilis MgtE magnesium transporter can functionally compensate TRPM7-deficiency in vertebrate B-cells.
Scharenberg et al., Seattle, United States. In Plos One, 2011
Recent studies have shown that the vertebrate magnesium transporters Solute carrier family 41, members 1 and 2 (SLC41A1, SLC41A2) and Magnesium transporter subtype 1 (MagT1) can endow vertebrate B-cells lacking the ion-channel kinase Transient receptor potential cation channel, subfamily M, member 7 (TRPM7) with a capacity to grow and proliferate.
TRPM7 regulates polarized cell movements.
Runnels et al., United States. In Biochem J, 2011
Surprisingly, expression of the Mg²+ transporter SLC41A2 (solute carrier family 41 member 2) is also effective in restoring the change in cell morphology, disruption of the cytoskeleton and directional cell motility caused by depletion of the channel-kinase.
TRPM7 regulates gastrulation during vertebrate embryogenesis.
Runnels et al., Philadelphia, United States. In Dev Biol, 2011
The phenotype caused by depletion of the Ca(2+)- and Mg(2+)-permeant TRPM7 is suppressed by expression of a dominant negative form of Rac, as well as by Mg(2+) supplementation or by expression of the Mg(2+) transporter SLC41A2.
Vascular biology of magnesium and its transporters in hypertension.
Touyz et al., Ottawa, Canada. In Magnes Res, 2010
Mg2+ influx is controlled by recently cloned transporters including Mrs2p, SLC41A1, SLC41A2, ACDP2, MagT1, TRPM6 and TRPM7.
SLC41A2 encodes a plasma-membrane Mg2+ transporter.
Scharenberg et al., Seattle, United States. In Biochem J, 2007
Evaluation of the expression of several members of the SLC41 (solute carrier family 41) family, which exhibit homology with the MgtE class of prokaryotic putative bivalent-cation transporters, demonstrated that one, SLC41A2 (solute carrier family 41 member 2), is expressed in both wild-type and TRPM7-deficient DT40 cells.
Functional characterization of the mouse [corrected] solute carrier, SLC41A2.
GeneRIF
Quamme et al., Vancouver, Canada. In Biochem Biophys Res Commun, 2005
SLC41A2 is a Mg2+ transporter that might be involved in magnesium homeostasis in epithelial cells
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