gopubmed logo
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Solute carrier family 34

SLC34A2, NaPi-IIb, Npt2b, NaPi2b
The protein encoded by this gene is a pH-sensitive sodium-dependent phosphate transporter. Phosphate uptake is increased at lower pH. Defects in this gene are a cause of pulmonary alveolar microlithiasis. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, May 2010] (from NCBI)
Top mentioned proteins: IIa, CAN, HAD, ACID, Ros
Papers on SLC34A2
ROS1 copy number alterations are frequent in non-small cell lung cancer.
Salido et al., Barcelona, Spain. In Oncotarget, Feb 2016
To characterize ROS1 partners, probes for CD74, EZR, SLC34A2 and SDC3 genes were developed.
A salmon DNA scaffold promotes osteogenesis through activation of sodium-dependent phosphate cotransporters.
Ikebe et al., Fukuoka, Japan. In Biochem Biophys Res Commun, Jan 2016
Interestingly, we found that the inclusion of DNA in osteoblastic cell cultures upregulated the expression of sodium-dependent phosphate (NaPi) cotransporters, SLC20A1 and SLC34A2, in MC3T3-E1 cells in a time dependent manner.
Ameloblast Modulation and Transport of Cl-, Na+, and K+ during Amelogenesis.
DenBesten et al., Amsterdam, Netherlands. In J Dent Res, Dec 2015
Two major transporters recently identified in ameloblasts are the Na(+)K(+)-dependent calcium transporter NCKX4 and the Na(+)-dependent HPO4 (2-) (Pi) cotransporter NaPi-2b.
Pulmonary alveolar microlithiasis: review of the 1022 cases reported worldwide.
Resta et al., Conversano, Italy. In Eur Respir Rev, Dec 2015
It is caused by mutation of the SLC34A2 gene encoding the type IIb sodium phosphate cotransporter in alveolar type II cells.
Modeling pulmonary alveolar microlithiasis by epithelial deletion of the Npt2b sodium phosphate cotransporter reveals putative biomarkers and strategies for treatment.
McCormack et al., Cincinnati, United States. In Sci Transl Med, Dec 2015
Inactivating mutations in SLC34A2, which encodes the NPT2b sodium-dependent phosphate cotransporter, has been proposed as a cause of PAM.
Enhanced SLC34A2 in breast cancer stem cell-like cells induces chemotherapeutic resistance to doxorubicin via SLC34A2-Bmi1-ABCC5 signaling.
He et al., China. In Tumour Biol, Dec 2015
We aim to investigate the relationship between SLC34A2 and chemoresistance in BCSCs and identify the underlying mechanisms by which SLC34A2 regulates chemoresistance in BCSCs.
Intestinal phosphate transport: a therapeutic target in chronic kidney disease and beyond?
Marks et al., London, United Kingdom. In Pediatr Nephrol, Mar 2015
Our current understanding is that the intestinal type II sodium phosphate cotransporter, NaPi-IIb, plays a significant role in absorption.
Relationship between sodium-dependent phosphate transporter (NaPi-IIc) function and cellular vacuole formation in opossum kidney cells.
Miyamoto et al., Tokushima, Japan. In J Med Invest, 2014
The ability to form vacuoles is specific to electroneutral NaPi-IIc, and not electrogenic NaPi-IIa or NaPi-IIb.
The Role of Sodium-Dependent Phosphate Transporter in Phosphate Homeostasis.
Miyamoto et al., Tokushima, Japan. In J Nutr Sci Vitaminol (tokyo), 2014
SLC34A1 and SCL34A3 are predominantly expressed in the kidney, whereas SLC34A2 is expressed in the small intestine.
The sodium-phosphate co-transporter SLC34A2, and pulmonary alveolar microlithiasis: Presentation of an inbred family and a novel truncating mutation in exon 3.
Perrotti et al., Roma, Italy. In Respir Med Case Rep, 2014
Loss of function mutations in the gene SLC34A2 coding for the sodium phosphate co-transporter (NaPi-IIb) are responsible for genetic forms of alveolar microlithiasis.
Up-Regulation of Intestinal Phosphate Transporter NaPi-IIb (SLC34A2) by the Kinases SPAK and OSR1.
Lang et al., Bingen am Rhein, Germany. In Kidney Blood Press Res, 2014
The present study thus tested whether SPAK and/or OSR1 contributes to the regulation of the intestinal Na+-coupled phosphate co-transporter NaPi-IIb (SLC34A2).
Deregulated Renal Calcium and Phosphate Transport during Experimental Kidney Failure.
NIGRAM Consortium et al., Nijmegen, Netherlands. In Plos One, 2014
Furthermore, kidney failure was characterized by enhanced renal expression of the transient receptor potential cation channel subfamily V member 5 (TRPV5), calbindin-D28k, and sodium-dependent Pi transporter type 2b (NaPi2b), whereas the renal expression of sodium-dependent Pi transporter type 2a (NaPi2a) and type 3 (PIT2) were reduced.
Role of NPT2b in health and chronic kidney disease.
Schiavi et al., Framingham, United States. In Curr Opin Nephrol Hypertens, 2014
This editorial provides evidence of the importance of intestinal NPT2b in health and chronic kidney disease (CKD).
Regulation of cellular transport by klotho protein.
Dermaku-Sopjani et al., Pristina, Serbia. In Curr Protein Pept Sci, 2013
Klotho regulates diverse calcium and potassium ion channels, as well as several carriers including the Na(+)-coupled excitatory amino acid transporters EAAT3 and EAAT4, the Na(+)-coupled phosphate cotransporters, NaPi-IIa and NaPi-IIb, and a Na(+)/K(+)-ATPase.
Pulmonary alveolar microlithiasis: report of two brothers with the same illness and review of literature.
Al-Hayali et al., Southend-on-Sea, United Kingdom. In Bmj Case Rep, 2013
The disease is caused by mutations in the gene SLC34A2 encoding sodium-dependent phosphate co-transporter.
In silico analysis and immunohistochemical characterization of NaPi2b protein expression in ovarian carcinoma with monoclonal antibody Mx35.
Alves et al., São Paulo, Brazil. In Appl Immunohistochem Mol Morphol, 2012
a comprehensive analysis indicates that SCL34A2 is the only gene of the several phosphate transporters genes whose expression differentiates normal from carcinoma samples, suggesting it might exert a major role in ovarian carcinomas.
SLC34A2 gene mutation may explain comorbidity of pulmonary alveolar microlithiasis and aortic valve sclerosis.
Simonsen et al., In Am J Respir Crit Care Med, 2012
identified 2 cases of pulmonary alveolar microlithiasis(PAM) with new mutations of SLC34A2 gene; identified the NaPi-IIb in a aortic valve; hypothesize that mutations in SLC34A2 may play a role in development of aortic valve calcification and arteriosclerosis
High phosphorus diet-induced changes in NaPi-IIb phosphate transporter expression in the rat kidney: DNA microarray analysis.
Nakai et al., Tokyo, Japan. In Plos One, 2011
NaPi-IIb is upregulated in the kidney in response to the active excretion of phosphate in HP diet-fed rats
Pentavalent arsenate transport by zebrafish phosphate transporter NaPi-IIb1.
Liu et al., United States. In Zebrafish, 2011
zebrafish NaPi-IIb1 is likely the transport protein that is responsible for arsenic accumulation in vivo
Immunohistochemical analysis of NaPi2b protein (MX35 antigen) expression and subcellular localization in human normal and cancer tissues.
Filonenko et al., Ukraine. In Exp Oncol, 2011
study provides the data on the pattern of NaPi2b expression and cellular localization in breast, lung and ovarian cancers
share on facebooktweetadd +1mail to friends