GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 19 Dec 2016.
Src-like-adaptor
SLAP, Src-like adaptor protein, Src-like adapter protein, SLA-1
an adaptor protein; may be involved in the signaling of receptor tyrosine kinases [RGD, Feb 2006] (from
NCBI)
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Top mentioned proteins:
Src, CAN, Fyb, MHC, Cbl
Papers on
SLAP
Adhesions of extracellular surface-layer associated proteins in Lactobacillus M5-L and Q8-L.
New
Harbin, China. In J Dairy Sci, Jan 2016
UNASSIGNED: Surface-layer associated proteins (SLAP) that envelop Lactobacillus paracasei ssp.
PD-L1 expression is increased in monocyte derived dendritic cells in response to porcine circovirus type 2 and porcine reproductive and respiratory syndrome virus infections.
New
Blacksburg, United States. In Vet Immunol Immunopathol, Dec 2015
In this study, porcine monocyte derived dendritic cells (MoDC) were infected with different combinations of PCV2 and porcine reproductive and respiratory syndrome virus (PRRSV) and evaluated for expression levels of PD-L1, as well as the expression levels of swine major histocompatibility complexes 1 and 2 (SLA-1 and SLA-2) as a measure of MoDC stimulatory capacity.
A combined prediction strategy increases identification of peptides bound with high affinity and stability to porcine MHC class I molecules SLA-1*04:01, SLA-2*04:01, and SLA-3*04:01.
New
Frederiksberg, Denmark. In Immunogenetics, Dec 2015
We have earlier reported the peptide binding motif of the porcine MHC-I molecules SLA-1*04:01 and SLA-2*04:01, identified by an ELISA affinity-based positional scanning combinatorial peptide library (PSCPL) approach.
Sequence variations of the locus-specific 5' untranslated regions of SLA class I genes and the development of a comprehensive genomic DNA-based high-resolution typing method for SLA-2.
New
Seoul, South Korea. In Tissue Antigens, Oct 2015
We performed a comparative analysis of the last 92 bp of the 5' untranslated region (UTR) to the beginning of exon 4 of six SLA classical class I-related genes, SLA-1, -2, -3, -4, -5, and -9, from 36 different sequences.
Role of SRC-like adaptor protein (SLAP) in immune and malignant cell signaling.
Review
New
Lund, Sweden. In Cell Mol Life Sci, Jul 2015
SRC-like adaptor protein (SLAP) is an adaptor protein structurally similar to the SRC family protein kinases.
RTK SLAP down: the emerging role of Src-like adaptor protein as a key player in receptor tyrosine kinase signaling.
Review
New
Toronto, Canada. In Cell Signal, Feb 2015
SLAP (Src like adaptor protein) contains adjacent Src homology 3 (SH3) and Src homology 2 (SH2) domains closely related in sequence to that of cytoplasmic Src family tyrosine kinases.
Establishing the pig as a large animal model for vaccine development against human cancer.
Copenhagen, Denmark. In Front Genet, 2014
Taking advantage of recombinant swine MHC class I molecules (SLAs), the peptide-SLA complex stability was measured for 198 IDO- or RhoC-derived 9-11mer peptides predicted to bind to SLA-1(*)04:01, -1(*)07:02, -2(*)04:01, -2(*)05:02, and/or -3(*)04:01.
The Emerging and Diverse Roles of Src-Like Adaptor Proteins in Health and Disease.
Review
Budapest, Hungary. In Mediators Inflamm, 2014
Although Src-like adaptor proteins (SLAP-1 and SLAP-2) were mainly studied in lymphocytes, where they act as negative regulators and provide fine control of receptor signaling, recently, several other functions of these proteins were discovered.
CD3ζ-chain expression of human T lymphocytes is regulated by TNF via Src-like adaptor protein-dependent proteasomal degradation.
GeneRIF
Budapest, Hungary. In J Immunol, 2012
These data provide evidence for src-like adaptor protein-dependent regulation of CD3 zeta-chain in the fine control of TCR signaling.
Tail-anchored membrane protein SLMAP is a novel regulator of cardiac function at the sarcoplasmic reticulum.
GeneRIF
Ottawa, Canada. In Am J Physiol Heart Circ Physiol, 2012
These data demonstrate that SLMAP is a regulator of E-C coupling at the level of the SR and its perturbation results in progressive deterioration of cardiac electrophysiology and function.
The Src-like adaptor protein regulates GM-CSFR signaling and monocytic dendritic cell maturation.
GeneRIF
Toronto, Canada. In J Immunol, 2011
Src-like adaptor protein (SLAP) functions as a negative regulator of the granulocyte-macrophage colony-stimulating factor receptor (GM-CSFR) generation of monocyte-derived dendritic cells of bone marrow origin.
SLAP deficiency enhances number and function of regulatory T cells preventing chronic autoimmune arthritis in SKG mice.
GeneRIF
Denver, United States. In J Immunol, 2011
SLAP deficiency dramatically reduces both the incidence and severity of arthritis and prevents development of chronic arthritis in the double SKG (mutant ZAP70) Src-like adapter protein (SLAP) knockout mouse model.
Increased expression of the tail-anchored membrane protein SLMAP in adipose tissue from type 2 Tally Ho diabetic mice.
GeneRIF
Hangzhou, China. In Exp Diabetes Res, 2010
SLMAP may be an important regulator of glucose uptake or involved in GLUT-4 fusion/translocation into the plasma membrane of mouse abdominal adipose tissue; changes in SLMAP expression are linked to hyperglycemia and diabetes.
SLAP, a regulator of immunoreceptor ubiquitination, signaling, and trafficking.
Review
Denver, United States. In Immunol Rev, 2009
Src-like adapter proteins (SLAP and SLAP-2) constitute a family of proteins that are expressed in a variety of cell types but are studied most extensively in lymphocytes.
The proline-rich sequence of CD3epsilon controls T cell antigen receptor expression on and signaling potency in preselection CD4+CD8+ thymocytes.
Impact
Marseille, France. In Nat Immunol, 2008
In contrast, in preselection CD4+CD8+ thymocytes, the CD3epsilon PRS acted together with the adaptor protein SLAP to promote CD3zeta degradation, thereby contributing to downregulation of TCR expression on the cell surface.
Listeriolysin O allows Listeria monocytogenes replication in macrophage vacuoles.
Impact
Toronto, Canada. In Nature, 2008
Listeriolysin O (LLO, encoded by hly), a pore-forming toxin essential for L. monocytogenes virulence, was necessary and sufficient for SLAP formation.
Src-like adaptor protein regulates TCR expression on thymocytes by linking the ubiquitin ligase c-Cbl to the TCR complex.
Impact
San Francisco, United States. In Nat Immunol, 2006
The adaptor molecule SLAP and E3 ubiquitin ligase c-Cbl each regulate expression of T cell receptor (TCR)-CD3 on thymocytes.
Signal transduction events regulating integrin function and T cell migration: new functions and complexity.
Review
Minneapolis, United States. In Immunol Res, 2002
These studies highlight novel functions for several signaling molecules, including the tyrosine kinases Itk and ZAP-70, and the adapter protein SLAP-130/Fyb.
Coupling of the TCR to integrin activation by Slap-130/Fyb.
Impact
Philadelphia, United States. In Science, 2001
SLAP-130/Fyb (SLP-76-associated phosphoprotein or Fyn-binding protein; also known as Fyb/Slap) is a hematopoietic-specific adapter, which associates with and modulates function of SH2-containing leukocyte phosphoprotein of 76 kilodaltons (SLP-76).
The Src-like adaptor protein downregulates the T cell receptor on CD4+CD8+ thymocytes and regulates positive selection.
Impact
San Francisco, United States. In Immunity, 2001
In this report, we show that the Src-like adaptor protein (SLAP) plays an important role in thymocyte development.
