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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Potassium channel, subfamily T, member 1

Slack, Slo2
Na(+)-activated potassium channel; may be involved in regulating the firing properties of neurons [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: Slick, CAN, OUT, HAD, ACID
Papers on Slack
Epilepsy-Related Slack Channel Mutants Lead to Channel Over-Activity by Two Different Mechanisms.
New
Zhang et al., Xuzhou, China. In Cell Rep, Feb 2016
Twelve sodium-activated potassium channel (KCNT1, Slack) genetic mutants have been identified from severe early-onset epilepsy patients.
Hydrophobic interactions between the S5 segment and the pore helix stabilizes the closed state of Slo2.1 potassium channels.
New
Sanguinetti et al., Salt Lake City, United States. In Biochim Biophys Acta, Jan 2016
UNASSIGNED: Under normal physiological conditions, Slo2.1K(+) channels are in a closed state unless activated by an elevation in [Na(+)]i.
Slack Sodium-activated Potassium Channel Membrane Expression Requires p38 Mitogen-Activated Protein Kinase Phosphorylation.
New
Bhattacharjee et al., Buffalo, United States. In Neuropharmacology, Jan 2016
The KNa channel Slack is an important protein to be studied as it is highly and ubiquitously expressed in DRG neurons and is important in the maintenance of their firing accommodation.
Differential distribution of the sodium-activated potassium channels Slick and Slack in mouse brain.
New
Schwarzer et al., Innsbruck, Austria. In J Comp Neurol, Dec 2015
KCNT2) and Slack (Slo2.2,
Cryo-electron microscopy structure of the Slo2.2 Na(+)-activated K(+) channel.
New
Impact
MacKinnon et al., New York City, United States. In Nature, Dec 2015
Here we present the structure of a complete Na(+)-activated K(+) channel, chicken Slo2.2, in the Na(+)-free state, determined by cryo-electron microscopy at a nominal resolution of 4.5 ångströms.
Anterior chamber depth studies.
New
Savini et al., Santa Monica, United States. In J Cataract Refract Surg, Sep 2015
FINANCIAL DISCLOSURE: Dr. Hoffer owns the registered trademark name "Hoffer(®)" and receives royalties for its commercial use from Alcon Laboratories, Inc., Appasamy Associates, Carl Zeiss Meditec AG, DGH Technology, Inc., Ellex iScience, Inc., Haag-Streit AG, Nidek Co., Ltd., Tomey Corp., Topcon Medical Systems, Inc., and Ziemer USA, Inc., as well as royalties from Slack, Inc. for the textbook IOL Power.
Granulomatous Lymphoproliferative Disorders: Granulomatous Slack Skin and Lymphomatoid Granulomatosis.
Review
New
Venkatarajan et al., Houston, United States. In Dermatol Clin, Jul 2015
The most common types of granulomatous CTCL are granulomatous mycosis fungoides and granulomatous slack skin.
Knockout of Slo2.2 enhances itch, abolishes KNa current, and increases action potential firing frequency in DRG neurons.
Lingle et al., Saint Louis, United States. In Elife, 2014
Here, we report the genetic disruption of both Kcnt1 and Kcnt2, confirm the loss of Slo2.2 and Slo2.1 protein, respectively, in KO animals, and define tissues enriched in Slo2 expression.
Channelopathies and dendritic dysfunction in fragile X syndrome.
Review
Johnston et al., Austin, United States. In Brain Res Bull, 2014
Several channelopathies, both soma-dendritic (L-type calcium channels, Slack potassium channels, h-channels, A-type potassium channels) and axo-somatic (BK channels and delayed rectifier potassium channels) were identified in the fmr1-/y mouse model of fragile X syndrome.
Emerging role of the KCNT1 Slack channel in intellectual disability.
Review
Kaczmarek et al., New Haven, United States. In Front Cell Neurosci, 2013
The sodium-activated potassium KNa channels Slack and Slick are encoded by KCNT1 and KCNT2, respectively.
Is slack an intrinsic seizure terminator?
Review
Igelström, Dunedin, New Zealand. In Neuroscientist, 2013
The recently discovered gene Slack encodes a sodium-activated potassium channel that mediates a major proportion of the outward current in many neurons.
Granulomatous slack skin disease: a review, in comparison with mycosis fungoides.
Review
Safaya et al., Mumbai, India. In J Eur Acad Dermatol Venereol, 2012
Granulomatous slack skin (GSS) is a rare cutaneous disorder characterized by the evolution of circumscribed erythematous loose skin masses, especially in the body folds, and histologically by a loss of elastic fibers and granulomatous T-cell infiltrates.
cAMP-dependent kinase does not modulate the Slack sodium-activated potassium channel.
GeneRIF
Bhattacharjee et al., Buffalo, United States. In Neuropharmacology, 2009
phosphorylation by protein kinase A does not acutely modulate the function and gating activation kinetics of Slack channels
The N-terminal domain of Slack determines the formation and trafficking of Slick/Slack heteromeric sodium-activated potassium channels.
GeneRIF
Kaczmarek et al., Albany, United States. In J Neurosci, 2009
Heteromer formation requires the N-terminal domain of Slack-B, one of the alternative splice variants of the Slack channel.
Slack and Slick KNa channels are required for the depolarizing afterpotential of acutely isolated, medium diameter rat dorsal root ganglion neurons.
GeneRIF
Ding et al., Wuhan, China. In Acta Pharmacol Sin, 2008
We conclude that Slack and Slick K(Na) channels are required for depolarizing afterpotential of medium diameter rat dorsal root ganglion neurons
The sodium-activated potassium channel Slack is modulated by hypercapnia and acidosis.
GeneRIF
Haddad et al., Washington, D.C., United States. In Neuroscience, 2008
Slack may play an important role in pathological conditions during which there is an increase in the intracellular concentrations of both acid and Na(+), such as in ischemia/hypoxia
Slack and Slick K(Na) channels regulate the accuracy of timing of auditory neurons.
GeneRIF
Kaczmarek et al., New Haven, United States. In J Neurosci, 2007
Slick and Slack are expressed at high levels auditory brainstem. Activation of these KNa channels allows temporal accuracy of firing to be increased at high frequencies of stimulation.
Myofibrils bear most of the resting tension in frog skeletal muscle.
Impact
Law et al., In Science, 1986
Slack sarcomere lengths and the rates of stress relaxation in these muscles were similar to those in skinned fibers, and sarcomere length remained unchanged during stress relaxation, as in skinned fibers.
Plant species intermediate for c3, c4 photosynthesis.
Impact
Laetsch et al., In Science, 1974
Mollugo verticillata is the first plant species reported which has characteristics of both C(3) (Calvin-Benson pathway) and C(4) (Hatch-Slack pathway) plants.
Carbon fixation and isotope discrimination by a crassulacean plant: dependence on the photoperiod.
Impact
Queiroz et al., In Science, 1974
This indicates that the mechanism of carbon fixation switches from the Calvin (C(3)) pathway to the Hatch-Slack (C(4)) pathway of primary enzymic operation.
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