The role of genetic factors in the etiology of temporomandibular disorders: a review.
Cagliari, Italy. In Cranio, Feb 2016
Such genes were mainly related to serotonin activity and metabolism, Tcellreceptor pathway, catecholamine activity and metabolism, estrogen activity, folate metabolism, glutathione activity, ANKH gene, major histocompatibility complex, extracellular matrix metabolism, genes studied in the orofacial pain prospective evaluation risk and assessment (OPPERA) study, and related to cytokines activity and metabolism.
Calcium pyrophosphate deposition disease: a review of epidemiologic findings.
Nottingham, United Kingdom. In Curr Opin Rheumatol, Dec 2015
It will summarize findings from a large dataset which reported that chondrocalcinosis results from a systemic predisposition, and that the association between chondrocalcinosis and polymorphisms in ANKH gene is independent of age and osteoarthritis.
The role of ANKH in pathologic mineralization of cartilage.
Camden, United States. In Curr Opin Rheumatol, Dec 2015
PURPOSE OF REVIEW: ANKH is the human homolog of a gene whose dysfunction in a mutant mouse strain results in progressive ankylosis of the spine as well as soft tissue mineralization.
The SCF-type E3 Ubiquitin Ligases as Cancer Targets.
Hamamatsu, Japan. In Curr Cancer Drug Targets, Dec 2015
F-box proteins form SCF (SKP1-Cullin1-F-box protein)-type ubiquitin (E3) ligases to selectively target their substrates for degradation via the ubiquitin-proteasome pathway.
MicroRNA regulation of F-box proteins and its role in cancer.
Memphis, United States. In Semin Cancer Biol, Nov 2015
F-box proteins function as the substrate-recognition components of the SKP1-CUL1-F-box (SCF)-ubiquitin ligase complex for the degradation of their protein targets by the ubiquitin-proteasome system.
SCF ubiquitin ligase-targeted therapies.
New York City, United States. In Nat Rev Drug Discov, 2014
F-box proteins are the substrate-targeting subunits of SKP1-CUL1-F-box protein (SCF) ubiquitin ligase complexes.
Roles of F-box proteins in cancer.
Boston, United States. In Nat Rev Cancer, 2014
F-box proteins, which are the substrate-recognition subunits of SKP1-cullin 1-F-box protein (SCF) E3 ligase complexes, have pivotal roles in multiple cellular processes through ubiquitylation and subsequent degradation of target proteins.
Mechanisms and function of substrate recruitment by F-box proteins.
New York City, United States. In Nat Rev Mol Cell Biol, 2013
S phase kinase-associated protein 1 (SKP1)-cullin 1 (CUL1)-F-box protein (SCF) ubiquitin ligase complexes use a family of F-box proteins as substrate adaptors to mediate the degradation of a large number of regulatory proteins involved in diverse processes.