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Sine oculis-related homeobox 4 homolog

Six4, AREC3
This gene encodes a member of the homeobox family, subfamily SIX. The drosophila homolog is a nuclear homeoprotein required for eye development. Studies in mouse show that this gene product functions as a transcription factor, and may have a role in the differentiation or maturation of neuronal cells. [provided by RefSeq, May 2010] (from NCBI)
Top mentioned proteins: Six1, Six3, SIX5, HAD, Six2
Papers on Six4
Amorphous silicon: new insights into an old material.
New
Auner et al., Frankfurt am Main, Germany. In Chemistry, Apr 2015
Amorphous silicon is synthesized by treating the tetrahalosilanes SiX4 (X=Cl, F) with molten sodium in high boiling polar and non-polar solvents such as diglyme or nonane to give a brown or a black solid showing different reactivities towards suitable reagents.
Association of PAX2 and Other Gene Mutations with the Clinical Manifestations of Renal Coloboma Syndrome.
Wada et al., Kanazawa, Japan. In Plos One, 2014
Moreover, four other sequence variants (CHD7, SALL4, KIF26B, and SIX4) were also confirmed, including a potentially pathogenic novel KIF26B mutation.
Novel polymorphisms of SIX4 gene and their association with body measurement traits in Qinchuan cattle.
Zan et al., China. In Gene, 2014
Sine oculis homeobox homolog 4 (SIX4) gene belongs to the sine oculis/SIX gene family, which includes six members in vertebrates.
Interstitial deletion 14q22.3-q23.2: genotype-phenotype correlation.
Martínez et al., Madrid, Spain. In Am J Med Genet A, 2014
The 6.5 Mb deletion contains 27 genes, including three genes of the SIX family: SIX1, SIX4, and SIX6.
Longissimus dorsi transcriptome analysis of purebred and crossbred Iberian pigs differing in muscle characteristics.
Silió et al., Madrid, Spain. In Bmc Genomics, 2013
Twenty-nine RF were found, some of them with known relationship with tissue development (MSTN, SIX4, IRX3), adipogenesis (CEBPD, PPARGC1B), or extracellular matrix processes (MAX, MXI1).
Phosphine and diphosphine complexes of silicon(IV) halides.
Reid et al., Southampton, United Kingdom. In Inorg Chem, 2013
The reaction of SiX4 (X = Cl or Br) with PMe3 in anhydrous CH2Cl2 forms trans-[SiX4(PMe3)2], while the diphosphines, Me2P(CH2)2PMe2, Et2P(CH2)2PEt2, and o-C6H4(PMe2)2 form cis-[SiX4(diphosphine)], all containing six-coordinate silicon centers.
A highly conserved effector in Fusarium oxysporum is required for full virulence on Arabidopsis.
Manners et al., Australia. In Mol Plant Microbe Interact, 2012
lycopersici SIX1, SIX4, SIX8, and SIX9 in the genome of Arabidopsis infecting isolate Fo5176.
Genesis of muscle fiber-type diversity during mouse embryogenesis relies on Six1 and Six4 gene expression.
GeneRIF
Maire et al., Paris, France. In Dev Biol, 2011
Data show that absence of Six1 and Six4 leads to the development of dorsal myofibers lacking expression of fast-type muscle genes, and mainly expressing a slow-type muscle program.
Insect Tc-six4 marks a unit with similarity to vertebrate placodes.
Bucher et al., Göttingen, Germany. In Dev Biol, 2011
The cranial placodes develop from a panplacodal region which is specifically marked by genes of the eyes absent/eya and two "six homeobox" family members (sine oculis/six1 and six4).
Cooperation between myogenic regulatory factors and SIX family transcription factors is important for myoblast differentiation.
Blais et al., Ottawa, Canada. In Nucleic Acids Res, 2010
We have conducted a functional genomic study of the role played by SIX1 and SIX4 during the differentiation of skeletal myoblasts, a model of adult muscle regeneration.
Six family genes control the proliferation and differentiation of muscle satellite cells.
GeneRIF
Kawakami et al., Tochigi, Japan. In Exp Cell Res, 2010
Six4 and Six5 repressed, while Six1 activated myogenin expression, suggesting that the differential regulation of myogenin expression is responsible for the differential effects of Six genes
Expression of Six1 and Six4 in mouse taste buds.
GeneRIF
Kawakami et al., Tōbetsu, Japan. In J Mol Histol, 2010
These results suggest that Six1 and Six4 genes are expressed in the taste bud cells, in newly formed or surviving type-II cells.
Six1 and Six4 gene expression is necessary to activate the fast-type muscle gene program in the mouse primary myotome.
GeneRIF
Maire et al., Paris, France. In Dev Biol, 2010
Six1 and Six4 expression is required to specifically activate fast-type muscle genes
Effector gene screening allows unambiguous identification of Fusarium oxysporum f. sp. lycopersici races and discrimination from other formae speciales.
Rep et al., Sint-Katelijne-Waver, Belgium. In Fems Microbiol Lett, 2009
In addition, SIX4 can be used for the identification of race 1 strains, while polymorphisms in SIX3 can be exploited to differentiate race 2 from race 3 strains.
Initiation of olfactory placode development and neurogenesis is blocked in mice lacking both Six1 and Six4.
GeneRIF
Xu et al., New York City, United States. In Dev Biol, 2009
The threshold of Six1/4 may be crucial for the expression of olfactory specific genes and Six1 and Six4 may act synergistically to mediate olfactory placode specification and patterning through Fgf and Bmp signaling pathways.
Colobomatous macrophthalmia with microcornea syndrome maps to the 2p23-p16 region.
Akarsu et al., İstanbul, Turkey. In Am J Med Genet A, 2007
Subsequently, the chromosome 14q24 region containing the CHX10, SIX1, and SIX4 genes were also excluded.
A new locus for autosomal dominant posterior polar cataract in Moroccan Jews maps to chromosome 14q22-23.
Hejtmancik et al., In J Med Genet, 2006
The positional and functional candidate genes SIX1, SIX4, SIX6, OTX2, and ARHJ were excluded as the cause of cataract in these families.
Deletion at 14q22-23 indicates a contiguous gene syndrome comprising anophthalmia, pituitary hypoplasia, and ear anomalies.
Jamieson et al., Sydney, Australia. In Am J Med Genet A, 2006
Translocation breakpoint analysis using FISH and high-resolution microarray comparative genomic hybridization (CGH) has identified a 9.66 Mb deleted region on the long arm of chromosome 14 which includes the genes BMP4, OTX2, RTN1, SIX6, SIX1, and SIX4.
D-six4 plays a key role in patterning cell identities deriving from the Drosophila mesoderm.
Jarman et al., Edinburgh, United Kingdom. In Dev Biol, 2006
We show that D-six4, which encodes a Six family transcription factor, is required for the appropriate development of most cell types deriving from the non-dorsal mesoderm - the fat body, somatic cells of the gonad, and a specific subset of somatic muscles.
CHX10 mutations cause non-syndromic microphthalmia/ anophthalmia in Arab and Jewish kindreds.
Birk et al., Beersheba, Israel. In Hum Genet, 2004
Assuming a founder effect in each of the families, we performed homozygosity mapping using polymorphic markers adjacent to human homologues of genes known to be associated with eye absence in various species, namely EYA1, EYA2, EYA3, SIX4, SIX6, PAX6 and CHX10.
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