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Sine oculis-related homeobox 2 homolog

Six2, six1a
This gene is a member of the vertebrate gene family which encode proteins homologous to the Drosophila 'sine oculis' homeobox protein. The encoded protein is a transcription factor which, like other members of this gene family, may be involved in limb or eye development. [provided by RefSeq, Dec 2008] (from NCBI)
Top mentioned proteins: CAN, PAX2, Six1, SalI, Six3
Papers on Six2
Master regulators in primary skin fibroblast fate reprogramming in a human ex-vivo model of chronic wounds.
New
Dugast-Darzacq et al., Paris, France. In Wound Repair Regen, Jan 2016
Conversely, downregulation of MEOX2, SIX2 and MAF causes reprogramming of fibroblasts to myofibroblasts even in absence of TGFbeta, the natural inducer of myofibroblast differentiation.
A new frontonasal dysplasia syndrome associated with deletion of the SIX2 gene.
New
Saal et al., Baltimore, United States. In Am J Med Genet A, Dec 2015
Chromosomal microarray identified a heterozygous 108.3 kilobase deletion of chromosome 2p21 segregating with phenotype and limited to the sine oculis homeobox gene SIX2 and surrounding noncoding DNA.
Nephron organoids derived from human pluripotent stem cells model kidney development and injury.
New
Impact
Bonventre et al., Boston, United States. In Nat Biotechnol, Nov 2015
By recapitulating metanephric kidney development in vitro, we generate SIX2(+)SALL1(+)WT1(+)PAX2(+) NPCs with 90% efficiency within 9 days of differentiation.
Preferential Propagation of Competent SIX2+ Nephronic Progenitors by LIF/ROCKi Treatment of the Metanephric Mesenchyme.
New
Perantoni et al., Frederick, United States. In Stem Cell Reports, Oct 2015
Passaged MM cells express the key stem cell regulators Six2 and Pax2 and remain competent to respond to WNT4 induction and form mature tubular epithelia and glomeruli.
Assessment of promoter methylation and expression of SIX2 as a diagnostic and prognostic biomarker in Wilms' tumor.
New
Wang et al., Zhengzhou, China. In Tumour Biol, Sep 2015
This study was designed to evaluate the utility of expression and DNA methylation patterns of the sine oculis homeobox homolog 2 (SIX2) gene in early diagnosis and prognosis of Wilms' tumor (WT).
Mutations of the SLIT2-ROBO2 pathway genes SLIT2 and SRGAP1 confer risk for congenital anomalies of the kidney and urinary tract.
New
Hildebrandt et al., Boston, United States. In Hum Genet, Aug 2015
We show that SRGAP1 is expressed in early mouse nephrogenic mesenchyme and that it is coexpressed with ROBO2 in SIX2-positive nephron progenitor cells of the cap mesenchyme in developing rat kidney.
Mutations in the SIX1/2 pathway and the DROSHA/DGCR8 miRNA microprocessor complex underlie high-risk blastemal type Wilms tumors.
New
Impact
Gessler et al., Würzburg, Germany. In Cancer Cell, Mar 2015
Recurrent mutations included a hotspot mutation (Q177R) in the homeo-domain of SIX1 and SIX2 in tumors with high proliferative potential (18.1% of blastemal cases); mutations in the DROSHA/DGCR8 microprocessor genes (18.2% of blastemal cases); mutations in DICER1 and DIS3L2; and alterations in IGF2, MYCN, and TP53, the latter being strongly associated with dismal outcome.
Homeoprotein Six2 promotes breast cancer metastasis via transcriptional and epigenetic control of E-cadherin expression.
Ford et al., Aurora, United States. In Cancer Res, 2015
In this study, we report the involvement of the kidney development transcription factor Six2 in the metastatic progression of human breast cancer.
The effector repertoire of Fusarium oxysporum determines the tomato xylem proteome composition following infection.
Takken et al., Amsterdam, Netherlands. In Front Plant Sci, 2014
To investigate their activities in the plant, the xylem sap proteome of plants inoculated with Fol wild-type or either AVR2, AVR3, SIX2, SIX5, or SIX6 knockout strains was analyzed with nano-Liquid Chromatography-Mass Spectrometry (nLC-MSMS).
Differential expression of retinal determination genes in the principal and secondary eyes of Cupiennius salei Keyserling (1877).
Eriksson et al., Vienna, Austria. In Evodevo, 2014
Later in development (180 to 280 h after egg laying), there is differential expression of the genes in disparate eye vesicles; for example, Cs-otxa is expressed only in posterior-lateral eye vesicles, Cs-otxb, Cs-six1a, and Cs-six3b in all three secondary eye vesicles, Cs-pax6a only in principal eye vesicles, Cs-six1b in posterior-median, and posterior-lateral eye vesicles, and Cs-six3a in lateral and principal eye vesicles.
SIX2 Effects on Wilms Tumor Biology.
Lovvorn et al., Nashville, United States. In Transl Oncol, 2014
Sine oculis homeobox 2 (SIX2) is a transcription factor expressed specifically in the CM, provides a critical mechanism for CM self-renewal, and remains persistently active in WT blastema, although its purpose in this childhood malignancy remains unclear.
Amniotic Fluid Derived Stem Cells with a Renal Progenitor Phenotype Inhibit Interstitial Fibrosis in Renal Ischemia and Reperfusion Injury in Rats.
Toelen et al., Leuven, Belgium. In Plos One, 2014
In the first part of this study, hAFSCs that highly expressed CD24, CD117, SIX2 and PAX2 were isolated and characterized.
Wilms' tumor blastemal stem cells dedifferentiate to propagate the tumor bulk.
Dekel et al., Israel. In Stem Cell Reports, 2014
Herein, by generating pure blastema WT xenografts, composed solely of cells expressing the renal developmental markers SIX2 and NCAM1, we surprisingly show that sorted ALDH1(+) WT CSCs do not correspond to earliest renal stem cells.
SIX2 and CITED1, markers of nephronic progenitor self-renewal, remain active in primitive elements of Wilms' tumor.
GeneRIF
Lovvorn et al., Nashville, United States. In J Pediatr Surg, 2012
Nuclear protein & mRNA expression of SIX2 were similar across all stages of disease, in favorable or unfavorable histology & in treatment failure or success. It is not found in normal kidney.
Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits.
Impact
Cho et al., South Korea. In Nat Genet, 2011
(in C12orf51) for high-density lipoprotein cholesterol, 2p21 (near SIX2-SIX3) for fasting plasma glucose, 19q13.33 (in RPS11) and 6q22.33 (in RSPO3) for renal traits, and 12q24.11
Balancing cell numbers during organogenesis: Six1a differentially affects neurons and sensory hair cells in the inner ear.
GeneRIF
Collazo et al., Los Angeles, United States. In Dev Biol, 2011
Balancing cell numbers during organogenesis: Six1a differentially affects neurons and sensory hair cells in the inner ear
Osmoregulatory defect in adult mice associated with deficient prenatal expression of six2.
GeneRIF
Lozanoff et al., Honolulu, United States. In Am J Physiol Regul Integr Comp Physiol, 2011
Results demonstrate impaired osmoregulatory mechanisms consistent with chronic renal failure in the Br/+ mouse and indicate that six2 haploinsufficiency has a direct effect on postnatal fluid and electrolyte handling associated with fluid imbalance.
Canonical Wnt9b signaling balances progenitor cell expansion and differentiation during kidney development.
GeneRIF
Carroll et al., Dallas, United States. In Development, 2011
wnt9b signaling regulates stem cell proliferation and differention in the developing kidney depending on the activity of the transcription factor Six2 in the responding cell.
Six family genes control the proliferation and differentiation of muscle satellite cells.
GeneRIF
Kawakami et al., Tochigi, Japan. In Exp Cell Res, 2010
Six4 and Six5 repressed, while Six1 activated myogenin expression, suggesting that the differential regulation of myogenin expression is responsible for the differential effects of Six genes
Uncapping the potential of renal stem cells.
Impact
Quaggin, Toronto, Canada. In Cell Stem Cell, 2008
six2-expressing mesenchymal cells exhibit hallmark stem cell traits, in that they appear to self-renew and are clonally multipotent for a range of nephron epithelial cell types.
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