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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 01 Aug 2015.

Sine oculis-related homeobox 1 homolog

Six1, TIP39, PTH2, Tuberoinfundibular peptide of 39 residues
The protein encoded by this gene is a homeobox protein that is similar to the Drosophila 'sine oculis' gene product. This gene is found in a cluster of related genes on chromosome 14 and is thought to be involved in limb development. Defects in this gene are a cause of autosomal dominant deafness type 23 (DFNA23) and branchiootic syndrome type 3 (BOS3). [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Parathyroid Hormone, BOP, CAN, HAD, Parathyroid Hormone-Related Protein
Papers using Six1 antibodies
Breast development in the first 2 years of life: an association with soy-based infant formulas.
Supplier
Williams Carmen J. et al., In Environmental Health Perspectives, 2007
... Blots were blocked with 5% milk in TBST and then incubated with either Six1 [sine oculis-related homeobox 1 homolog (Drosophila); 1:1,000; Abcam, Cambridge, UK] or β-actin ...
Papers on Six1
Quantitative Trait Locus Analysis of SIX1-SIX6 With Retinal Nerve Fiber Layer Thickness in Individuals of European Descent.
New
Weinreb et al., San Diego, United States. In Am J Ophthalmol, 31 Jul 2015
PURPOSE: To perform a quantitative trait locus (QTL) analysis and evaluate whether a locus between SIX1 and SIX6 is associated with retinal nerve fiber layer (RNFL) thickness in individuals of European descent.
Using Xenopus to discover new genes involved in Branchiootorenal spectrum disorders.
Review
New
Pignoni et al., Washington, D.C., United States. In Comp Biochem Physiol C Toxicol Pharmacol, 24 Jul 2015
Mutations in two genes, SIX1 and EYA1, have been identified in about half of the patients tested.
Overexpression of SIX1 is an independent prognostic marker in stage I - III colorectal cancer.
New
Koch et al., Dresden, Germany. In Int J Cancer, Jun 2015
Immunohistochemistry against SIX1 was performed on colorectal mucosa, adenomas, carcinomas-in-situ and primary adenocarcinomas.
Relationship between seminal plasma tuberoinfundibular peptide of 39 residues and sperm functional attributes in buffalo (Bubalus bubalis).
New
Ravindra et al., In Reprod Fertil Dev, Jun 2015
Matrix-assisted laser desorption ionisation time-of-flight analysis of one of the differentially expressed proteins, namely the 11-12 kDa protein, identified it as tuberoinfundibular peptide of 39 residues (TIP39).
International Union of Basic and Clinical Pharmacology. XCIII. The parathyroid hormone receptors-family B G protein-coupled receptors.
New
Impact
Vilardaga et al., Pittsburgh, United States. In Pharmacol Rev, Apr 2015
The type-2 parathyroid hormone receptor (PTHR2) binds a peptide ligand, called tuberoinfundibular peptide-39 (TIP39), and while the biologic role of the PTHR2/TIP39 system is not as defined as that of the PTHR1, it likely plays a role in the central nervous system as well as in spermatogenesis.
Recurrent DGCR8, DROSHA, and SIX homeodomain mutations in favorable histology Wilms tumors.
New
Impact
Perlman et al., Chicago, United States. In Cancer Cell, Mar 2015
We report the most common single-nucleotide substitution/deletion mutations in favorable histology Wilms tumors (FHWTs) to occur within SIX1/2 (7% of 534 tumors) and microRNA processing genes (miRNAPGs) DGCR8 and DROSHA (15% of 534 tumors).
Mutations in the SIX1/2 pathway and the DROSHA/DGCR8 miRNA microprocessor complex underlie high-risk blastemal type Wilms tumors.
New
Impact
Gessler et al., Würzburg, Germany. In Cancer Cell, Mar 2015
Recurrent mutations included a hotspot mutation (Q177R) in the homeo-domain of SIX1 and SIX2 in tumors with high proliferative potential (18.1% of blastemal cases); mutations in the DROSHA/DGCR8 microprocessor genes (18.2% of blastemal cases); mutations in DICER1 and DIS3L2; and alterations in IGF2, MYCN, and TP53, the latter being strongly associated with dismal outcome.
Evolution of parathyroid hormone receptor family and their ligands in vertebrate.
Review
New
Lee et al., Hong Kong, Hong Kong. In Front Endocrinol (lausanne), Dec 2014
The presence of the parathyroid hormones in vertebrates, including PTH, PTH-related peptide (PTHrP), and tuberoinfundibular peptide of 39 residues (TIP39), has been proposed to be the result of two rounds of whole genome duplication in the beginning of vertebrate diversification.
Gene Expression Data from the Moon Jelly, Aurelia, Provide Insights into the Evolution of the Combinatorial Code Controlling Animal Sense Organ Development.
New
Jacobs et al., Los Angeles, United States. In Plos One, Dec 2014
Here we show in the eye-bearing scyphozoan cnidarian Aurelia that the ectodermal photosensory domain of the developing medusa sensory structure known as the rhopalium expresses sine oculis (so)/six1/2 and eyes absent/eya, but not optix/six3/6 or pax (A&B).
Gene expression patterns and dynamics of the colonization of common bean (Phaseolus vulgaris L.) by highly virulent and weakly virulent strains of Fusarium oxysporum.
New
Díaz-Mínguez et al., Salamanca, Spain. In Front Microbiol, Dec 2014
Most of the virulence genes analyzed showed similar expression patterns in both strains, except SIX1, SIX6 and the gene encoding the transcription factor FTF1, which were highly upregulated in root crown and hypocotyl.
[The detection of strains of Esherichia coll producing Shiga toxin in populations of normal intestinal microbiota in children with functional disorders of gastrointestinal tract].
New
Rychkova et al., In Klin Lab Diagn, Nov 2014
The purpose was to detect presence of gens coding capacity of toxin production (six1, stx2).
Preoptic inputs and mechanisms that regulate maternal responsiveness.
Review
New
Stolzenberg et al., Budapest, Hungary. In J Neuroendocrinol, Oct 2014
Recent results on the pathway mediating the effects of suckling to the mPOA suggest that neurones containing the neuropeptide tuberoinfundibular peptide of 39 residues in the posterior thalamus are candidates for conveying the suckling information to the mPOA.
Genetics of primary open angle glaucoma.
Review
Araie et al., Tokyo, Japan. In Jpn J Ophthalmol, 2014
Several association studies have been conducted for candidate genes, and genome-wide association studies recently identified new susceptibility loci for POAG, namely, S1 RNA binding domain 1 region on chromosome 2p21, the caveolin 1 and caveolin 2 regions on 7q31, transmembrane and coiled-coil domain 1 region on 1q24, cyclin-dependent kinase inhibitor 2B antisense RNA on 9p21, the SIX1 and SIX6 regions on 14q24 and, possibly, the regulatory region of 8q22.
EYA1-SIX1 complex in neurosensory cell fate induction in the mammalian inner ear.
Review
Xu et al., New York City, United States. In Hear Res, 2013
The phosphatase-transactivator EYA1 interacts with the homeodomain protein SIX1 to form transcriptional activation complexes, which play essential roles in regulating cell proliferation, survival and induction of sensory and neuronal differentiation programs during inner ear development.
Regulation of Six1 expression by evolutionarily conserved enhancers in tetrapods.
GeneRIF
Kawakami et al., Tochigi, Japan. In Dev Biol, 2012
Studies indicate that the Six1 enhancers provide valuable tools to understand the mechanism of Six1 regulation and to manipulate gene expression in the developing embryo, particularly in the sensory organs.
EYA1 and SIX1 drive the neuronal developmental program in cooperation with the SWI/SNF chromatin-remodeling complex and SOX2 in the mammalian inner ear.
GeneRIF
Xu et al., New York City, United States. In Development, 2012
EYA1 and SIX1 drive the neuronal developmental program in cooperation with the SWI/SNF chromatin-remodeling complex and SOX2 in the mammalian inner ear.
Mutation screening of the EYA1, SIX1, and SIX5 genes in an East Asian cohort with branchio-oto-renal syndrome.
GeneRIF
Hsu et al., Taipei, Taiwan. In Laryngoscope, 2012
In East Asian populations, a SIX1 mutation has been reported in a Japanese family with branchio-oto (BO) syndrome.
SIX1 induces lymphangiogenesis and metastasis via upregulation of VEGF-C in mouse models of breast cancer.
GeneRIF
Ford et al., Aurora, United States. In J Clin Invest, 2012
A critical role for SIX1 in lymphatic dissemination of breast cancer cells, providing a direct mechanistic explanation for how VEGF-C expression is upregulated in breast cancer.
Epigenetic repression of cardiac progenitor gene expression by Ezh2 is required for postnatal cardiac homeostasis.
Impact
GeneRIF
Bruneau et al., San Francisco, United States. In Nat Genet, 2012
Ezh2-mediated repression of Six1 in differentiating cardiac progenitors is essential for stable gene expression and homeostasis in the postnatal heart.
Expression profiling identifies the cytoskeletal organizer ezrin and the developmental homeoprotein Six-1 as key metastatic regulators.
Impact
GeneRIF
Merlino et al., Bethesda, United States. In Nat Med, 2004
Data show that ezrin and the homeodomain-containing transcription factor Six-1 had essential roles in determining the metastatic fate of rhabdomyosarcoma cells.
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