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Sine oculis-related homeobox 1 homolog

Six1, TIP39, PTH2, Tuberoinfundibular peptide of 39 residues
The protein encoded by this gene is a homeobox protein that is similar to the Drosophila 'sine oculis' gene product. This gene is found in a cluster of related genes on chromosome 14 and is thought to be involved in limb development. Defects in this gene are a cause of autosomal dominant deafness type 23 (DFNA23) and branchiootic syndrome type 3 (BOS3). [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Parathyroid Hormone, BOP, CAN, HAD, Parathyroid Hormone-Related Protein
Papers using Six1 antibodies
Breast development in the first 2 years of life: an association with soy-based infant formulas.
Williams Carmen J. et al., In Environmental Health Perspectives, 2007
... Blots were blocked with 5% milk in TBST and then incubated with either Six1 [sine oculis-related homeobox 1 homolog (Drosophila); 1:1,000; Abcam, Cambridge, UK] or β-actin ...
Papers on Six1
A Genetic Variant in TGFBR3-CDC7 Is Associated with Visual Field Progression in Primary Open-Angle Glaucoma Patients from Singapore.
Vithana et al., Singapore, Singapore. In Ophthalmology, Dec 2015
Single nucleotide polymorphisms (SNPs) and their proxies from 10 POAG-associated loci (CAV1-CAV2, CDKN2B-AS1, SIX1-SIX6, an intergenic region on chromosome 8q22, ABCA1, GAS7, AFAP1, GMDS, PMM2, and TGFBR3-CDC7) identified from genome-wide association studies were tested for association with VF progression using logistic regression with an additive genetic model adjusting for age, gender, average intraocular pressure (IOP), central corneal thickness (CCT), and baseline vertical cup-to-disc ratio (VCDR).
Using Xenopus to discover new genes involved in branchiootorenal spectrum disorders.
Pignoni et al., Washington, D.C., United States. In Comp Biochem Physiol C Toxicol Pharmacol, Dec 2015
Mutations in two genes, SIX1 and EYA1, have been identified in about half of the patients tested.
Aberrant expression of homeobox gene SIX1 in Hodgkin lymphoma.
MacLeod et al., Braunschweig, Germany. In Oncotarget, Dec 2015
Here, we examined in HL homeobox gene SIX1 an additional regulator of this embryonal region mediating differentiation of placodal precursors.
The homeoprotein SIX1 controls cellular senescence through the regulation of p16INK4A and differentiation-related genes.
Palmero et al., Madrid, Spain. In Oncogene, Nov 2015
Here we show that SIX1, a member of the SIX family of homeobox transcriptional factors, is a novel repressor of senescence.
microRNA-188 is downregulated in oral squamous cell carcinoma and inhibits proliferation and invasion by targeting SIX1.
Liu et al., Beijing, China. In Tumour Biol, Nov 2015
Using fluorescence reporter assays, we confirmed that SIX1 was a direct target of miR-188 in OSCC cells.
Incubation of Fear Is Regulated by TIP39 Peptide Signaling in the Medial Nucleus of the Amygdala.
Usdin et al., Bethesda, United States. In J Neurosci, Oct 2015
Recent behavioral evidence suggests that the neuropeptide tuberoinfundibular peptide of 39 residues (TIP39), via its receptor, the parathyroid hormone 2 receptor (PTH2R), modulates fear memory.
Mutations in the SIX1/2 pathway and the DROSHA/DGCR8 miRNA microprocessor complex underlie high-risk blastemal type Wilms tumors.
Gessler et al., Würzburg, Germany. In Cancer Cell, Mar 2015
Recurrent mutations included a hotspot mutation (Q177R) in the homeo-domain of SIX1 and SIX2 in tumors with high proliferative potential (18.1% of blastemal cases); mutations in the DROSHA/DGCR8 microprocessor genes (18.2% of blastemal cases); mutations in DICER1 and DIS3L2; and alterations in IGF2, MYCN, and TP53, the latter being strongly associated with dismal outcome.
Recurrent DGCR8, DROSHA, and SIX homeodomain mutations in favorable histology Wilms tumors.
Perlman et al., Chicago, United States. In Cancer Cell, Mar 2015
We report the most common single-nucleotide substitution/deletion mutations in favorable histology Wilms tumors (FHWTs) to occur within SIX1/2 (7% of 534 tumors) and microRNA processing genes (miRNAPGs) DGCR8 and DROSHA (15% of 534 tumors).
The SIX1-EYA transcriptional complex as a therapeutic target in cancer.
Ford et al., Aurora, United States. In Expert Opin Ther Targets, Feb 2015
Abnormal over-expression of SIX1 and EYA in adult tissue is associated with the initiation and progression of diverse tumor types.
Evolution of parathyroid hormone receptor family and their ligands in vertebrate.
Lee et al., Hong Kong, Hong Kong. In Front Endocrinol (lausanne), 2014
The presence of the parathyroid hormones in vertebrates, including PTH, PTH-related peptide (PTHrP), and tuberoinfundibular peptide of 39 residues (TIP39), has been proposed to be the result of two rounds of whole genome duplication in the beginning of vertebrate diversification.
International Union of Basic and Clinical Pharmacology. XCIII. The parathyroid hormone receptors--family B G protein-coupled receptors.
Vilardaga et al., Pittsburgh, United States. In Pharmacol Rev, 2014
The type-2 parathyroid hormone receptor (PTHR2) binds a peptide ligand, called tuberoinfundibular peptide-39 (TIP39), and while the biologic role of the PTHR2/TIP39 system is not as defined as that of the PTHR1, it likely plays a role in the central nervous system as well as in spermatogenesis.
An Updated Review on the Genetics of Primary Open Angle Glaucoma.
Chalam et al., Riyadh, Saudi Arabia. In Int J Mol Sci, 2014
Recent genome-wide association studies (GWAS) have identified several single nucleotide polymorphisms (SNPs) at different loci including CAV1/CAV2, TMCO1, CDKN2B-AS1, CDC7-TGFBR3, SIX1/SIX6, GAS7 and ATOH7 to be associated with POAG and its related quantitative traits (endophenotypes).
Transcriptional profiles of pilocytic astrocytoma are related to their three different locations, but not to radiological tumor features.
Zakrzewska et al., Łódź, Poland. In Bmc Cancer, 2014
The most prominent differences were noted for IRX2, PAX3, CXCL14, LHX2, SIX6, CNTN1 and SIX1 genes expression even within different compartments of the supratentorial region.
Posterior eyespots in larval chitons have a molecular identity similar to anterior cerebral eyes in other bilaterians.
Hausen et al., Bergen, Norway. In Evodevo, 2014
Several transcription factors commonly involved in cerebral eye and brain development such as six1/2, eya, dachshund, lhx2/9 and prox are also expressed by all found photoreceptor cells, only pax6 being restricted to the anterior most cells.
Regulation of Six1 expression by evolutionarily conserved enhancers in tetrapods.
Kawakami et al., Tochigi, Japan. In Dev Biol, 2012
Studies indicate that the Six1 enhancers provide valuable tools to understand the mechanism of Six1 regulation and to manipulate gene expression in the developing embryo, particularly in the sensory organs.
EYA1 and SIX1 drive the neuronal developmental program in cooperation with the SWI/SNF chromatin-remodeling complex and SOX2 in the mammalian inner ear.
Xu et al., New York City, United States. In Development, 2012
EYA1 and SIX1 drive the neuronal developmental program in cooperation with the SWI/SNF chromatin-remodeling complex and SOX2 in the mammalian inner ear.
Mutation screening of the EYA1, SIX1, and SIX5 genes in an East Asian cohort with branchio-oto-renal syndrome.
Hsu et al., Taipei, Taiwan. In Laryngoscope, 2012
In East Asian populations, a SIX1 mutation has been reported in a Japanese family with branchio-oto (BO) syndrome.
SIX1 induces lymphangiogenesis and metastasis via upregulation of VEGF-C in mouse models of breast cancer.
Ford et al., Aurora, United States. In J Clin Invest, 2012
A critical role for SIX1 in lymphatic dissemination of breast cancer cells, providing a direct mechanistic explanation for how VEGF-C expression is upregulated in breast cancer.
Epigenetic repression of cardiac progenitor gene expression by Ezh2 is required for postnatal cardiac homeostasis.
Bruneau et al., San Francisco, United States. In Nat Genet, 2012
Ezh2-mediated repression of Six1 in differentiating cardiac progenitors is essential for stable gene expression and homeostasis in the postnatal heart.
Expression profiling identifies the cytoskeletal organizer ezrin and the developmental homeoprotein Six-1 as key metastatic regulators.
Merlino et al., Bethesda, United States. In Nat Med, 2004
Data show that ezrin and the homeodomain-containing transcription factor Six-1 had essential roles in determining the metastatic fate of rhabdomyosarcoma cells.
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