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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 28 Feb 2015.

Sine oculis-related homeobox 1 homolog

Six1, TIP39, PTH2, Tuberoinfundibular peptide of 39 residues
The protein encoded by this gene is a homeobox protein that is similar to the Drosophila 'sine oculis' gene product. This gene is found in a cluster of related genes on chromosome 14 and is thought to be involved in limb development. Defects in this gene are a cause of autosomal dominant deafness type 23 (DFNA23) and branchiootic syndrome type 3 (BOS3). [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Parathyroid Hormone, BOP, CAN, Parathyroid Hormone-Related Protein, HAD
Papers using Six1 antibodies
Breast development in the first 2 years of life: an association with soy-based infant formulas.
Supplier
Williams Carmen J. et al., In Environmental Health Perspectives, 2007
... Blots were blocked with 5% milk in TBST and then incubated with either Six1 [sine oculis-related homeobox 1 homolog (Drosophila); 1:1,000; Abcam, Cambridge, UK] or β-actin ...
Papers on Six1
International Union of Basic and Clinical Pharmacology. XCIII. The Parathyroid Hormone Receptors-Family B G Protein-Coupled Receptors.
New
Impact
Vilardaga et al., Pittsburgh, United States. In Pharmacol Rev, 30 Apr 2015
The type-2 parathyroid hormone receptor (PTHR2) binds a peptide ligand, called tuberoinfundibular peptide-39 (TIP39), and while the biologic role of the PTHR2/TIP39 system is not as defined as that of the PTHR1, it likely plays a role in the central nervous system as well as in spermatogenesis.
Genetic variants associated with different risks for high tension glaucoma and normal tension glaucoma in a Chinese population.
New
Sun et al., Shanghai, China. In Invest Ophthalmol Vis Sci, 24 Mar 2015
13 previously reported single nucleotide polymorphisms (SNPs) located at 4 gene regions (TMCO1, CDKN2B-AS1, ATOH7 and SIX1/SIX6) were genotyped.
Recurrent DGCR8, DROSHA, and SIX Homeodomain Mutations in Favorable Histology Wilms Tumors.
New
Impact
Perlman et al., Chicago, United States. In Cancer Cell, 09 Mar 2015
We report the most common single-nucleotide substitution/deletion mutations in favorable histology Wilms tumors (FHWTs) to occur within SIX1/2 (7% of 534 tumors) and microRNA processing genes (miRNAPGs) DGCR8 and DROSHA (15% of 534 tumors).
Mutations in the SIX1/2 Pathway and the DROSHA/DGCR8 miRNA Microprocessor Complex Underlie High-Risk Blastemal Type Wilms Tumors.
New
Impact
Gessler et al., Würzburg, Germany. In Cancer Cell, 09 Mar 2015
Recurrent mutations included a hotspot mutation (Q177R) in the homeo-domain of SIX1 and SIX2 in tumors with high proliferative potential (18.1% of blastemal cases); mutations in the DROSHA/DGCR8 microprocessor genes (18.2% of blastemal cases); mutations in DICER1 and DIS3L2; and alterations in IGF2, MYCN, and TP53, the latter being strongly associated with dismal outcome.
PFOA and PFOS are associated with reduced expression of the parathyroid hormone 2 receptor (PTH2R) gene in women.
New
Harries et al., Exeter, United Kingdom. In Chemosphere, 28 Feb 2015
We measured the relationship between PFOA or PFOS serum levels and the in vivo expression of the Parathyroid hormone 1 and 2 genes (PTH, PTH2), Parathyroid hormone 1 and 2 receptor genes (PTH1R, PTH2R) and the parathyroid hormone-like (PTHLH) gene in peripheral blood from a cross-sectional population study designed to assess the potential health effects of these chemicals.
The SIX1-EYA transcriptional complex as a therapeutic target in cancer.
New
Ford et al., Aurora, United States. In Expert Opin Ther Targets, 28 Feb 2015
Abnormal over-expression of SIX1 and EYA in adult tissue is associated with the initiation and progression of diverse tumor types.
Six1 overexpression at early stages of HPV16-mediated transformation of human keratinocytes promotes differentiation resistance and EMT.
New
Creek et al., Columbia, United States. In Virology, 01 Feb 2015
Previous studies in our laboratory discovered that SIX1 mRNA expression increased during in vitro progression of HPV16-immortalized human keratinocytes (HKc/HPV16) toward a differentiation-resistant (HKc/DR) phenotype.
The Genetics of POAG in Black South Africans: A Candidate Gene Association Study.
New
Ramsay et al., Johannesburg, South Africa. In Sci Rep, Dec 2014
No association with POAG was identified with tagging SNPs in TMCO1, CAV1/CAV2, CYP1B1, COL1A2, COL5A1, CDKN2B/CDKN2BAS-1, SIX1/SIX6 or the chromosome 2p16 regions and there were no associations with CCT or VCDR.
Genetics of primary open angle glaucoma.
Review
Araie et al., Tokyo, Japan. In Jpn J Ophthalmol, 2014
Several association studies have been conducted for candidate genes, and genome-wide association studies recently identified new susceptibility loci for POAG, namely, S1 RNA binding domain 1 region on chromosome 2p21, the caveolin 1 and caveolin 2 regions on 7q31, transmembrane and coiled-coil domain 1 region on 1q24, cyclin-dependent kinase inhibitor 2B antisense RNA on 9p21, the SIX1 and SIX6 regions on 14q24 and, possibly, the regulatory region of 8q22.
Association of known common genetic variants with primary open angle, primary angle closure, and pseudoexfoliation glaucoma in Pakistani cohorts.
den Hollander et al., Nijmegen, Netherlands. In Mol Vis, 2013
METHODS: Six variants in CDKN2B-AS1 (rs4977756), CDKN2B (rs1063192), ATOH7 (rs1900004), CAV1 (rs4236601), TMCO1 (rs4656461), and SIX1 (rs10483727) were genotyped using TaqMan assays.
EYA1-SIX1 complex in neurosensory cell fate induction in the mammalian inner ear.
Review
Xu et al., New York City, United States. In Hear Res, 2013
The phosphatase-transactivator EYA1 interacts with the homeodomain protein SIX1 to form transcriptional activation complexes, which play essential roles in regulating cell proliferation, survival and induction of sensory and neuronal differentiation programs during inner ear development.
Regulation of Six1 expression by evolutionarily conserved enhancers in tetrapods.
GeneRIF
Kawakami et al., Tochigi, Japan. In Dev Biol, 2012
Studies indicate that the Six1 enhancers provide valuable tools to understand the mechanism of Six1 regulation and to manipulate gene expression in the developing embryo, particularly in the sensory organs.
EYA1 and SIX1 drive the neuronal developmental program in cooperation with the SWI/SNF chromatin-remodeling complex and SOX2 in the mammalian inner ear.
GeneRIF
Xu et al., New York City, United States. In Development, 2012
EYA1 and SIX1 drive the neuronal developmental program in cooperation with the SWI/SNF chromatin-remodeling complex and SOX2 in the mammalian inner ear.
Mutation screening of the EYA1, SIX1, and SIX5 genes in an East Asian cohort with branchio-oto-renal syndrome.
GeneRIF
Hsu et al., Taipei, Taiwan. In Laryngoscope, 2012
In East Asian populations, a SIX1 mutation has been reported in a Japanese family with branchio-oto (BO) syndrome.
SIX1 induces lymphangiogenesis and metastasis via upregulation of VEGF-C in mouse models of breast cancer.
GeneRIF
Ford et al., Aurora, United States. In J Clin Invest, 2012
A critical role for SIX1 in lymphatic dissemination of breast cancer cells, providing a direct mechanistic explanation for how VEGF-C expression is upregulated in breast cancer.
Epigenetic repression of cardiac progenitor gene expression by Ezh2 is required for postnatal cardiac homeostasis.
Impact
GeneRIF
Bruneau et al., San Francisco, United States. In Nat Genet, 2012
Ezh2-mediated repression of Six1 in differentiating cardiac progenitors is essential for stable gene expression and homeostasis in the postnatal heart.
Regulation of calcium sensing receptor trafficking by RAMPs.
Review
Henley et al., Montpellier, France. In Adv Exp Med Biol, 2011
Some years after this initial discovery, it was established that RAMPs can accompany four additional class B G Protein-Coupled Receptors-GPCRs- (PTH1, PTH2, glucagon receptor and VPAC1) to the PM.(1)
Novel potential regulators of maternal adaptations during lactation: tuberoinfundibular peptide 39 and amylin.
Review
Dobolyi, Budapest, Hungary. In J Neuroendocrinol, 2011
TIP39 is the ligand of the parathyroid hormone 2 receptor (PTH2 receptor) is induced in the posterior intralaminar complex of the thalamus (PIL) during lactation.
Hereditary hearing loss and deafness genes in Japan.
Review
Kitamura et al., Tokyo, Japan. In J Med Dent Sci, 2010
Finally, the genes related to the enlargement of vestibular aqueduct of inner ear abnormality, SLC26A4, EYA1 and SIX1 are discussed.
Expression profiling identifies the cytoskeletal organizer ezrin and the developmental homeoprotein Six-1 as key metastatic regulators.
Impact
GeneRIF
Merlino et al., Bethesda, United States. In Nat Med, 2004
Data show that ezrin and the homeodomain-containing transcription factor Six-1 had essential roles in determining the metastatic fate of rhabdomyosarcoma cells.
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