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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 10 Dec 2014.

Sine oculis-related homeobox 1 homolog

Six1, TIP39, PTH2, Tuberoinfundibular peptide of 39 residues
The protein encoded by this gene is a homeobox protein that is similar to the Drosophila 'sine oculis' gene product. This gene is found in a cluster of related genes on chromosome 14 and is thought to be involved in limb development. Defects in this gene are a cause of autosomal dominant deafness type 23 (DFNA23) and branchiootic syndrome type 3 (BOS3). [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Parathyroid Hormone, BOP, CAN, HAD, Parathyroid Hormone-Related Protein
Papers using Six1 antibodies
Breast development in the first 2 years of life: an association with soy-based infant formulas.
Supplier
Williams Carmen J. et al., In Environmental Health Perspectives, 2007
... Blots were blocked with 5% milk in TBST and then incubated with either Six1 [sine oculis-related homeobox 1 homolog (Drosophila); 1:1,000; Abcam, Cambridge, UK] or β-actin ...
Papers on Six1
PFOA and PFOS are associated with reduced expression of the parathyroid hormone 2 receptor (PTH2R) gene in women.
New
Harries et al., Exeter, United Kingdom. In Chemosphere, 28 Feb 2015
We measured the relationship between PFOA or PFOS serum levels and the in vivo expression of the Parathyroid hormone 1 and 2 genes (PTH, PTH2), Parathyroid hormone 1 and 2 receptor genes (PTH1R, PTH2R) and the parathyroid hormone-like (PTHLH) gene in peripheral blood from a cross-sectional population study designed to assess the potential health effects of these chemicals.
Six1 overexpression at early stages of HPV16-mediated transformation of human keratinocytes promotes differentiation resistance and EMT.
New
Creek et al., Columbia, United States. In Virology, 01 Feb 2015
Previous studies in our laboratory discovered that SIX1 mRNA expression increased during in vitro progression of HPV16-immortalized human keratinocytes (HKc/HPV16) toward a differentiation-resistant (HKc/DR) phenotype.
Association of open-angle glaucoma Loci with incident glaucoma in the blue mountains eye study.
New
Craig et al., Adelaide, Australia. In Am J Ophthalmol, 31 Jan 2015
RESULTS: Two loci also known to be associated with cup-to-disc ratio as well as OAG (9p21 near CDKN2B-AS1 and SIX1/SIX6) were both significantly associated with incident OAG in the Blue Mountains Eye Study cohort (P = .006
DNA Copy Number Variants of Known Glaucoma Genes in Relation to Primary Open-Angle Glaucoma.
New
Hauser et al., Augusta, United States. In Invest Ophthalmol Vis Sci, 20 Dec 2014
We further limited our investigation to CNVs in known POAG-related genes, including CDKN2B-AS1, TMCO1, SIX1/SIX6, CAV1/CAV2, the LRP12-ZFPM2 region, GAS7, ATOH7, FNDC3B, CYP1B1, MYOC, OPTN, WDR36, SRBD1, TBK1, and GALC.
Involvement of genetic variants associated with primary open-angle glaucoma in pathogenic mechanisms and family history of glaucoma.
New
Tsukahara et al., Japan. In Am J Ophthalmol, 18 Dec 2014
METHODS: Japanese patients with NTG (n=213) and HTG (n=212) and 191 control subjects were genotyped for five non-IOP-related genetic variants predisposing to POAG near the SRBD1, ELOVL5, CDKN2B/CDKN2B-AS1, SIX1/SIX6 and ATOH7 genes.
Comparison of gene expression between mandibular and iliac bone-derived cells.
New
Kwon et al., Taegu, South Korea. In Clin Oral Investig, 05 Dec 2014
The most significantly differentially regulated genes were associated with skeletal system development or morphogenesis (SIX1, MSX1, MSX2, HAND2, PRRX1, OSR2, HOX gene family, PITX2).
miR-204 functions as a tumor suppressor by regulating SIX1 in NSCLC.
New
Chen et al., Nanjing, China. In Febs Lett, 16 Nov 2014
Moreover, miR-204 expression negatively correlated with homeobox protein SIX1 expression, tumor size and metastasis.
SIX1 promotes tumor lymphangiogenesis by coordinating TGFβ signals that increase expression of VEGF-C.
New
Gao et al., Wuhan, China. In Cancer Res, Nov 2014
Here, we report that sine oculis homeobox homolog 1 (SIX1), expressed in tumor cells, can promote tumor lymphangiogenesis and lymph node metastasis by coordinating with TGFβ to increase the expression of VEGF-C.
Genetics of primary open angle glaucoma.
Review
New
Araie et al., Tokyo, Japan. In Jpn J Ophthalmol, Jan 2014
Several association studies have been conducted for candidate genes, and genome-wide association studies recently identified new susceptibility loci for POAG, namely, S1 RNA binding domain 1 region on chromosome 2p21, the caveolin 1 and caveolin 2 regions on 7q31, transmembrane and coiled-coil domain 1 region on 1q24, cyclin-dependent kinase inhibitor 2B antisense RNA on 9p21, the SIX1 and SIX6 regions on 14q24 and, possibly, the regulatory region of 8q22.
Association of known common genetic variants with primary open angle, primary angle closure, and pseudoexfoliation glaucoma in Pakistani cohorts.
New
den Hollander et al., Nijmegen, Netherlands. In Mol Vis, Dec 2013
METHODS: Six variants in CDKN2B-AS1 (rs4977756), CDKN2B (rs1063192), ATOH7 (rs1900004), CAV1 (rs4236601), TMCO1 (rs4656461), and SIX1 (rs10483727) were genotyped using TaqMan assays.
EYA1-SIX1 complex in neurosensory cell fate induction in the mammalian inner ear.
Review
New
Xu et al., New York City, United States. In Hear Res, Mar 2013
The phosphatase-transactivator EYA1 interacts with the homeodomain protein SIX1 to form transcriptional activation complexes, which play essential roles in regulating cell proliferation, survival and induction of sensory and neuronal differentiation programs during inner ear development.
Regulation of Six1 expression by evolutionarily conserved enhancers in tetrapods.
GeneRIF
Kawakami et al., Tochigi, Japan. In Dev Biol, 2012
Studies indicate that the Six1 enhancers provide valuable tools to understand the mechanism of Six1 regulation and to manipulate gene expression in the developing embryo, particularly in the sensory organs.
EYA1 and SIX1 drive the neuronal developmental program in cooperation with the SWI/SNF chromatin-remodeling complex and SOX2 in the mammalian inner ear.
GeneRIF
Xu et al., New York City, United States. In Development, 2012
EYA1 and SIX1 drive the neuronal developmental program in cooperation with the SWI/SNF chromatin-remodeling complex and SOX2 in the mammalian inner ear.
SIX1 induces lymphangiogenesis and metastasis via upregulation of VEGF-C in mouse models of breast cancer.
GeneRIF
Ford et al., Aurora, United States. In J Clin Invest, 2012
A critical role for SIX1 in lymphatic dissemination of breast cancer cells, providing a direct mechanistic explanation for how VEGF-C expression is upregulated in breast cancer.
Mutation screening of the EYA1, SIX1, and SIX5 genes in an East Asian cohort with branchio-oto-renal syndrome.
GeneRIF
Hsu et al., Taipei, Taiwan. In Laryngoscope, 2012
In East Asian populations, a SIX1 mutation has been reported in a Japanese family with branchio-oto (BO) syndrome.
Epigenetic repression of cardiac progenitor gene expression by Ezh2 is required for postnatal cardiac homeostasis.
Impact
GeneRIF
Bruneau et al., San Francisco, United States. In Nat Genet, 2012
Ezh2-mediated repression of Six1 in differentiating cardiac progenitors is essential for stable gene expression and homeostasis in the postnatal heart.
Regulation of calcium sensing receptor trafficking by RAMPs.
Review
Henley et al., Montpellier, France. In Adv Exp Med Biol, 2011
Some years after this initial discovery, it was established that RAMPs can accompany four additional class B G Protein-Coupled Receptors-GPCRs- (PTH1, PTH2, glucagon receptor and VPAC1) to the PM.(1)
Novel potential regulators of maternal adaptations during lactation: tuberoinfundibular peptide 39 and amylin.
Review
Dobolyi, Budapest, Hungary. In J Neuroendocrinol, 2011
TIP39 is the ligand of the parathyroid hormone 2 receptor (PTH2 receptor) is induced in the posterior intralaminar complex of the thalamus (PIL) during lactation.
Hereditary hearing loss and deafness genes in Japan.
Review
Kitamura et al., Tokyo, Japan. In J Med Dent Sci, 2010
Finally, the genes related to the enlargement of vestibular aqueduct of inner ear abnormality, SLC26A4, EYA1 and SIX1 are discussed.
Expression profiling identifies the cytoskeletal organizer ezrin and the developmental homeoprotein Six-1 as key metastatic regulators.
Impact
GeneRIF
Merlino et al., Bethesda, United States. In Nat Med, 2004
Data show that ezrin and the homeodomain-containing transcription factor Six-1 had essential roles in determining the metastatic fate of rhabdomyosarcoma cells.
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