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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Mar 2014.

Sine oculis-related homeobox 1 homolog

Six1, TIP39, PTH2, Tuberoinfundibular peptide of 39 residues
The protein encoded by this gene is a homeobox protein that is similar to the Drosophila 'sine oculis' gene product. This gene is found in a cluster of related genes on chromosome 14 and is thought to be involved in limb development. Defects in this gene are a cause of autosomal dominant deafness type 23 (DFNA23) and branchiootic syndrome type 3 (BOS3). [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Parathyroid Hormone, BOP, Parathyroid Hormone-Related Protein, CAN, HAD
Papers using Six1 antibodies
Breast development in the first 2 years of life: an association with soy-based infant formulas.
Supplier
Williams Carmen J. et al., In Environmental Health Perspectives, 2007
... Blots were blocked with 5% milk in TBST and then incubated with either Six1 [sine oculis-related homeobox 1 homolog (Drosophila); 1:1,000; Abcam, Cambridge, UK] or β-actin ...
Papers on Six1
MicroRNA-30a regulates zebrafish myogenesis via targeting the transcription factor Six1.
New
Ford et al., In J Cell Sci, 14 Apr 2014
UNLABELLED: Precise spatiotemporal regulation of the SIX1 homeoprotein is required to coordinate vital tissue development, including myogenesis.
Sine oculis homeobox homolog 1 promotes α5β1-mediated invasive migration and metastasis of cervical cancer cells.
New
Gao et al., Wuhan, China. In Biochem Biophys Res Commun, 07 Apr 2014
UNLABELLED: Sine oculis homeobox homolog 1 (SIX1) has been supposed to be correlated with the metastasis and poor prognosis of several malignancies.
MiR-30b regulates migration and invasion of human colorectal cancer via SIX1.
New
Gao et al., In Biochem J, 05 Apr 2014
We validated SIX1, a member of the six-homeodomain family of transcription factorsand an EMT (epithelial-to-mesenchymal transition) promoting gene, as the direct target of miR-30b.
Interstitial deletion 14q22.3-q23.2: Genotype-phenotype correlation.
New
Martínez et al., Madrid, Spain. In Am J Med Genet A, 31 Mar 2014
The 6.5 Mb deletion contains 27 genes, including three genes of the SIX family: SIX1, SIX4, and SIX6.
Six1 promotes epithelial-mesenchymal transition and malignant conversion in human papillomavirus type 16-immortalized human keratinocytes.
New
Creek et al., Columbia, United States. In Carcinogenesis, 26 Mar 2014
UNLABELLED: Six1, a member of the Six family of homeodomain transcription factors, is overexpressed in various human cancers, and SIX1 overexpression is associated with tumor progression and metastasis.
Expression of osteogenic molecules in the caudate nucleus and gray matter and their potential relevance for basal ganglia calcification in hypoparathyroidism.
New
Sreenivas et al., In J Clin Endocrinol Metab, 19 Mar 2014
The mRNA expression of bone-transcription-factors (Runx2/osterix), bone morphogenic-proteins (BMP 2 and 4), osteonectin, osteopontin, osteocalcin, vitamin-D-receptor, calcium-sensing-receptor, Na-phosphate-transporters (PiT1, PiT2), NMDAR2b, carbonic-anhydrase-II (CA-II), PTH1 and PTH2-receptors (PTH1R, PTH2R) and PTH-related-peptide were assessed by RT-PCR.
Sineoculis homeobox homolog 1 protein overexpression as an independent biomarker for pancreatic ductal adenocarcinoma.
New
Lin et al., Yanji, China. In Exp Mol Pathol, 28 Feb 2014
Sineoculis homeobox homolog 1 (SIX1) is a member of the SIX gene family.
Genetics of primary open angle glaucoma.
New
Araie et al., Tokyo, Japan. In Jpn J Ophthalmol, Jan 2014
Several association studies have been conducted for candidate genes, and genome-wide association studies recently identified new susceptibility loci for POAG, namely, S1 RNA binding domain 1 region on chromosome 2p21, the caveolin 1 and caveolin 2 regions on 7q31, transmembrane and coiled-coil domain 1 region on 1q24, cyclin-dependent kinase inhibitor 2B antisense RNA on 9p21, the SIX1 and SIX6 regions on 14q24 and, possibly, the regulatory region of 8q22.
Gene expression-based comparison of the human secretory neuroepithelia of the brain choroid plexus and the ocular ciliary body: potential implications for glaucoma.
New
Bergen et al., Amsterdam, Netherlands. In Fluids Barriers Cns, Dec 2013
Three POAG disease genes were expressed significantly higher in the CPE than the NPE, namely CDH1, CDKN2B and SIX1.
EYA1-SIX1 complex in neurosensory cell fate induction in the mammalian inner ear.
Review
New
Xu et al., New York City, United States. In Hear Res, Mar 2013
The phosphatase-transactivator EYA1 interacts with the homeodomain protein SIX1 to form transcriptional activation complexes, which play essential roles in regulating cell proliferation, survival and induction of sensory and neuronal differentiation programs during inner ear development.
Regulation of Six1 expression by evolutionarily conserved enhancers in tetrapods.
GeneRIF
Kawakami et al., Tochigi, Japan. In Dev Biol, 2012
Studies indicate that the Six1 enhancers provide valuable tools to understand the mechanism of Six1 regulation and to manipulate gene expression in the developing embryo, particularly in the sensory organs.
EYA1 and SIX1 drive the neuronal developmental program in cooperation with the SWI/SNF chromatin-remodeling complex and SOX2 in the mammalian inner ear.
GeneRIF
Xu et al., New York City, United States. In Development, 2012
EYA1 and SIX1 drive the neuronal developmental program in cooperation with the SWI/SNF chromatin-remodeling complex and SOX2 in the mammalian inner ear.
SIX1 induces lymphangiogenesis and metastasis via upregulation of VEGF-C in mouse models of breast cancer.
GeneRIF
Ford et al., Aurora, United States. In J Clin Invest, 2012
A critical role for SIX1 in lymphatic dissemination of breast cancer cells, providing a direct mechanistic explanation for how VEGF-C expression is upregulated in breast cancer.
Mutation screening of the EYA1, SIX1, and SIX5 genes in an East Asian cohort with branchio-oto-renal syndrome.
GeneRIF
Hsu et al., Taipei, Taiwan. In Laryngoscope, 2012
In East Asian populations, a SIX1 mutation has been reported in a Japanese family with branchio-oto (BO) syndrome.
Epigenetic repression of cardiac progenitor gene expression by Ezh2 is required for postnatal cardiac homeostasis.
Impact
GeneRIF
Bruneau et al., San Francisco, United States. In Nat Genet, 2012
Ezh2-mediated repression of Six1 in differentiating cardiac progenitors is essential for stable gene expression and homeostasis in the postnatal heart.
Regulation of calcium sensing receptor trafficking by RAMPs.
Review
Henley et al., Montpellier, France. In Adv Exp Med Biol, 2011
Some years after this initial discovery, it was established that RAMPs can accompany four additional class B G Protein-Coupled Receptors-GPCRs- (PTH1, PTH2, glucagon receptor and VPAC1) to the PM.(1)
Novel potential regulators of maternal adaptations during lactation: tuberoinfundibular peptide 39 and amylin.
Review
Dobolyi, Budapest, Hungary. In J Neuroendocrinol, 2011
TIP39 is the ligand of the parathyroid hormone 2 receptor (PTH2 receptor) is induced in the posterior intralaminar complex of the thalamus (PIL) during lactation.
Hereditary hearing loss and deafness genes in Japan.
Review
Kitamura et al., Tokyo, Japan. In J Med Dent Sci, 2010
Finally, the genes related to the enlargement of vestibular aqueduct of inner ear abnormality, SLC26A4, EYA1 and SIX1 are discussed.
The TIP39-PTH2 receptor system: unique peptidergic cell groups in the brainstem and their interactions with central regulatory mechanisms.
Review
Usdin et al., Budapest, Hungary. In Prog Neurobiol, 2010
Tuberoinfundibular peptide of 39 residues (TIP39) is the recently purified endogenous ligand of the previously orphan G-protein coupled parathyroid hormone 2 receptor (PTH2R).
Expression profiling identifies the cytoskeletal organizer ezrin and the developmental homeoprotein Six-1 as key metastatic regulators.
Impact
GeneRIF
Merlino et al., Bethesda, United States. In Nat Med, 2004
Data show that ezrin and the homeodomain-containing transcription factor Six-1 had essential roles in determining the metastatic fate of rhabdomyosarcoma cells.
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