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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

SIT1 Sit1p

SIT1, SLC6A20, XT3, SHP2-interacting transmembrane adaptor protein
Transport of small hydrophilic substances across cell membranes is mediated by substrate-specific transporter proteins which have been classified into several families of related genes. The protein encoded by this gene is a member of the subgroup of transporter with unidentified substrates within the Na+ and Cl- coupled transporter family. This gene is expressed in kidney, and its alternative splicing generates 2 transcript variants. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, HAD, V1a, AT1, CAN
Papers using SIT1 antibodies
Global analysis of protein localization in budding yeast
Lesuisse Emmanuel et al., In Traffic (Copenhagen, Denmark), 2002
... SIT1-GFP::HIS3Clontech ...
GITR Activation Induces an Opposite Effect on Alloreactive CD4+ and CD8+ T Cells in Graft-Versus-Host Disease
van den Brink Marcel R.M. et al., In The Journal of Experimental Medicine, 1996
... Antimurine CD16/CD32 FcR block (2.4G2), TNFR1 (55R-593), TNF (MP6-XT3), and all of the following fluorochrome labeled and purified antibodies against murine Ag were obtained from BD Biosciences: CD4 (RM4-5), CD8 (53-6.7),
Papers on SIT1
Association Analysis of SLC6A20 Polymorphisms With Hirschsprung Disease.
Shin et al., Seoul, South Korea. In J Pediatr Gastroenterol Nutr, Jan 2016
Recently, our genome-wide association study has identified solute carrier family 6, proline IMINO transporter, member 20 (SLC6A20) as one of the potential risk factors for HSCR development.
Na+-dependent and Na+-independent betaine transport across the apical membrane of rat renal epithelium.
Ilundáin et al., Sevilla, Spain. In Biochim Biophys Acta, Oct 2015
The concentrative system is the Sodium/Imino-acid Transporter 1 (SIT1) because it is Na+- and Cl--dependent, electrogenic and is inhibited by an anti-SIT1 antibody.
Genotypic diversity of multidrug-, quinolone- and extensively drug-resistant Mycobacterium tuberculosis isolates in Thailand.
Chaiprasert et al., Bangkok, Thailand. In Infect Genet Evol, Jun 2015
Spoligotyping identified the Beijing strain (SIT1) as the most predominant genotype (n=139; 72.4%).
Tuberculosis - A global emergency: Tools and methods to monitor, understand, and control the epidemic with specific example of the Beijing lineage.
Rastogi et al., Les Abymes, Guadeloupe. In Tuberculosis (edinb), Jun 2015
Although the proportion of SIT1 pattern vs. other patterns was very high (93%); the proportion of MDR was highest for an emerging genotype SIT190 (p < 0.0001).
Myosin 1b Regulates Amino Acid Transport by Associating Transporters with the Apical Plasma Membrane of Kidney Cells.
Coluccio et al., Boston, United States. In Plos One, 2014
In opossum kidney (OK) 3B/2 epithelial cells, which are derived from PTs, expressed rat Myo1b-GFP colocalized in patched microvilli with expressed mouse V5-tagged SIT1 (SIT1-V5), which mediates neutral amino acid transport in OK cells.
Discrepancies in Drug Susceptibility Test for Tuberculosis Patients Resulted from the Mixed Infection and the Testing System.
Li et al., Tianjin, China. In Biomed Res Int, 2014
The spoligotyping results showed that, of all the 20 paired strains, 11 paired isolates belonged to the Beijing genotype and 6 paired isolates belonged to SIT1634, and that each of the remaining 3 paired isolates had two genotypes, namely, SIT1 and SIT1634.
Trends in molecular epidemiology of drug-resistant tuberculosis in Republic of Karelia, Russian Federation.
Narvskaya et al., Saint Petersburg, Russia. In Bmc Microbiol, 2014
RESULTS: The largest spoligotypes were SIT1 (Beijing family, n = 42) and SIT40 (T family, n = 5).
Drug resistance and molecular epidemiology of Mycobacterium tuberculosis in Mexico: a systematic review.
Garza-González et al., Mexico. In Salud Publica Mex, 2014
SIT1 Beijing genotype has been reported in six states from Mexico.
Predominance of Beijing genotype in extensively drug resistant Mycobacterium tuberculosis isolates from a tertiary care hospital in New Delhi, India.
Myneedu et al., New Delhi, India. In Int J Mycobacteriol, 2013
SIT1/Beijing represented the largest cluster (n=21, 42%), followed by SIT26/CAS1-Delhi (n=10, 20%) and SIT 53/T1 (n=8 isolates; 16%).
Cell volume regulation in mammalian oocytes and preimplantation embryos.
Zhou et al., Ottawa, Canada. In Mol Reprod Dev, 2012
The primary role of these is glycine accumulation via the GLYT1 transporter, with a secondary contribution by betaine accumulation via the SIT1 transporter.
A genome-wide association study of metabolic traits in human urine.
Nauck et al., München, Germany. In Nat Genet, 2011
Variants at three of these loci have previously been linked with important clinical outcomes: SLC7A9 is a risk locus for chronic kidney disease, NAT2 for coronary artery disease and genotype-dependent response to drug toxicity, and SLC6A20 for iminoglycinuria.
The transmembrane adaptor protein SIT inhibits TCR-mediated signaling.
Simeoni et al., Magdeburg, Germany. In Plos One, 2010
SIT as an important modulator of TCR-mediated signaling that regulates T-cell activation, homeostasis and tolerance
A novel function of Aft1 in regulating ferrioxamine B uptake: Aft1 modulates Arn3 ubiquitination in Saccharomyces cerevisiae.
Yun et al., Seoul, South Korea. In Biochem J, 2009
These results suggest that Aft1 interacts with Arn3 and may regulate the ubiquitination of Arn3 in the cytosolic compartment.
Sodium translocation by the iminoglycinuria associated imino transporter (SLC6A20).
Bröer et al., Canberra, Australia. In Mol Membr Biol, 2009
Using homology modeling we identified two highly conserved Na(+)-binding sites and a putative Cl(-)-binding site of SLC6A20.
Kidney amino acid transport.
Camargo et al., Zürich, Switzerland. In Pflugers Arch, 2009
A new finding is that the luminal Na(+)-dependent neutral amino acid transporters of the SLC6 family require an associated protein for their surface expression as shown for the Hartnup transporter B(0)AT1 (SLC6A19) and suggested for the L: -proline transporter SIT1 (IMINO(B), SLC6A20) and for B(0)AT3 (XT2, SLC6A18).
SIT and TRIM determine T cell fate in the thymus.
Simeoni et al., Magdeburg, Germany. In J Immunol, 2008
SIT and T cell receptor-interacting molecule (TRIM) regulate cell fate of developing thymocytes and are essential regulators of central tolerance.
Substrate- and ubiquitin-dependent trafficking of the yeast siderophore transporter Sit1.
Belgareh-Touzé et al., Paris, France. In Traffic, 2008
analysis of substrate- and ubiquitin-dependent trafficking of the yeast siderophore transporter Sit1
Deciphering the mechanisms of intestinal imino (and amino) acid transport: the redemption of SLC36A1.
Anderson et al., Newcastle upon Tyne, United Kingdom. In Biochim Biophys Acta, 2007
However, it is the sodium/imino and amino acid cotransporter SLC6A20 which corresponds to the betaine carrier (identified in hamster, 1960s) and IMINO transporter (identified in rabbit and guinea pig, 1980s).
The SLC6 orphans are forming a family of amino acid transporters.
Bröer, Canberra, Australia. In Neurochem Int, 2006
This was subsequently confirmed by the identification of SLC6A20 as the long-sought IMINO system, a proline transporter found in kidney, intestine and brain.
A suppressor of a HIS4 transcriptional defect encodes a protein with homology to the catalytic subunit of protein phosphatases.
Fink et al., Cambridge, United States. In Cell, 1989
Two of these suppressors, SIT1 and SIT2, are encoded by RPB1 and RPB2, the genes for the two largest subunits of RNA polymerase II.
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