SIRT4 regulates cancer cell survival and growth after stress.
South Korea. In Biochem Biophys Res Commun, Feb 2016
Although mitochondrial SIRT4 has been shown to be involved in cellular stress response and tumor suppression, its roles in survival and drug resistance of cancer cells are not well determined.
Sirt4: the glutamine gatekeeper.
Madrid, Spain. In Cancer Cell, 2013
In this issue of Cancer Cell, Jeong and colleagues report that an important component of the DNA damage response is the SIRT4-mediated blockade of glutamine catabolism.