Sirtuins-mediators of maternal obesity-induced complications in offspring?
Sydney, Australia. In Faseb J, Jan 2016
Sirtuins (SIRTs), particularly SIRT1 and SIRT3, are NAD(+)-dependent deacetylases that regulate metabolic balance and stress responses in both central and peripheral tissues, of which dysregulation is a well-established mediator for the development and effects of obesity.
The role of sirtuins in cardiac disease.
Newark, United States. In Am J Physiol Heart Circ Physiol, Nov 2015
Seven sirtuin family proteins (Sirt1-7) have been identified as mammalian SIR2 orthologs, localized in different subcellular compartments, namely, the cytoplasm (Sirt1, 2), the mitochondria (Sirt3, 4, 5), and the nucleus (Sirt1, 2, 6, 7).