Association of 32 type 1 diabetes risk loci in Pakistani patients.
Islamabad, Pakistan. In Diabetes Res Clin Pract, Apr 2015
RESULTS: Our results showed significant association of 10 single nucleotide polymorphisms (SNPs) with T1D at p<0.01, including HLA-DQA1/rs9272346, ERBB3/rs2292239, SIRPG/rs2281808, IL2-KIAA1109/rs4505848, GLIS3/rs7020673, CD226/rs763361, PTPN2/rs478582, IKZF1/rs10272724, BACH2/rs11755527, C6orf173/rs9388489, whereas 5 more SNPs showed their association at 0.01<p<0.05 in Pakistani population.
Association between type 1 diabetes and GWAS SNPs in the southeast US Caucasian population.
Augusta, United States. In Genes Immun, 2011
Analysis of the samples identified 18 SNPs (PTPN22, INS, IFIH1, SH2B3, ERBB3, CTLA4, C14orf181, CTSH, CLEC16A, CD69, ITPR3, C6orf173, SKAP2, PRKCQ, RNLS, IL27, SIRPG and CTRB2) with putative association.
Signal regulatory proteins in the immune system.
Amsterdam, Netherlands. In J Immunol, 2006
Our analysis reveals SIRPs as a diverse multigene family of immune receptors, which includes inhibitory SIRPalpha, activating SIRPbeta, nonsignaling SIRPgamma, and soluble SIRPdelta members.