DNMT1 as a molecular target in a multimodality-resistant phenotype in tumor cellsmore suppliers
In Molecular Cancer, 2007
... Santa Cruz Biotechnology (Santa Cruz, CA), anti-p38, anti-p44/42, anti-cfos, anti-cjun, anti-junB, anti-junD from Active Motif, anti-Sirt1 from Biomol, anti-Stat3 from Upstate, anti-histone-H3 ...
Programmed Hyperphagia in Offspring of Obese Dams: Altered Expression of Hypothalamic Nutrient Sensors, Neurogenic Factors and Epigenetic Modulators.
Torrance, United States. In Appetite, Feb 2016
We determined the protein expression of energy sensors (mTOR, pAMPK), epigenetic factors (DNA methylase, DNMT1; histone deacetylase, SIRT1/HDAC1), neurogenic factors (Hes1, Mash1, Ngn3) and appetite/satiety neuropeptides (AgRP/POMC) in newborn hypothalamus and adult arcuate nucleus (ARC).
Sirtuins-mediators of maternal obesity-induced complications in offspring?
Sydney, Australia. In Faseb J, Jan 2016
Sirtuins (SIRTs), particularly SIRT1 and SIRT3, are NAD(+)-dependent deacetylases that regulate metabolic balance and stress responses in both central and peripheral tissues, of which dysregulation is a well-established mediator for the development and effects of obesity.
Potential Modulation of Sirtuins by Oxidative Stress.
Montevideo, Uruguay. In Oxid Med Cell Longev, Dec 2015
Seven isoforms are identified in mammals (SIRT1-7), all of them sharing a conserved catalytic core and showing differential subcellular localization and activities.
Beneficial action of resveratrol: How and why?
Córdoba, Argentina. In Nutrition, Oct 2015
This increases the cytosolic cAMP that activates Epac1/CaMKKβ/AMPK/SIRT1/PGC-1α pathway, which in turn facilitates increased oxidation of fatty acids, mitochondrial biogenesis, mitochondrial respiration, and gluconeogenesis.
The chemical biology of sirtuins.
Zhenjiang, China. In Chem Soc Rev, Sep 2015
Over the past years since the discovery of its founding member (i.e. the yeast silent information regulator 2 (sir2) protein) in 2000, the sirtuin-catalyzed deacylation reaction has been demonstrated to play an important regulatory role in multiple crucial cellular processes such as transcription, DNA damage repair, and metabolism.
NNMT: A Bad Actor in Fat Makes Good in Liver.
Iowa City, United States. In Cell Metab, Sep 2015
Though murine NNMT knockdown in fat and liver prevents weight gain on high-fat diet, Hong et al. (2015) now show that high hepatic expression of NNMT improves lipid parameters via SIRT1 stabilization.
Sparse whole-genome sequencing identifies two loci for major depressive disorder.
More papers using
In Nature, Aug 2015
Here, using low-coverage whole-genome sequencing of 5,303 Chinese women with recurrent MDD selected to reduce phenotypic heterogeneity, and 5,337 controls screened to exclude MDD, we identified, and subsequently replicated in an independent sample, two loci contributing to risk of MDD on chromosome 10: one near the SIRT1 gene (P = 2.53 × 10(-10)), the other in an intron of the LHPP gene (P = 6.45 × 10(-12)).
The p110delta isoform of PI 3-kinase negatively controls RhoA and PTEN
In PLoS ONE, 2006
... from Invitrogen (Carlsbad, CA); Y-27632 (4-[(1R)-1-aminoethyl]-N-pyridin-4-yl-cyclohehaxe-1-carboxamide), SP600125, TAT-TI-JIP were obtained from Calbiochem (Darmstadt, Germany), rabbit anti-SIRT1 , β-catenin (Santa Cruz Biotechnology Inc., Santa Cruz, CA), ...