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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

SIR2 Sir2p

Sir2, SIRT1, Sir2p
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008] (from NCBI)
Top mentioned proteins: V1a, CAN, Histone, p53, AGE
Papers using Sir2 antibodies
Nmnat2 delays axon degeneration in superior cervical ganglia dependent on its NAD synthesis activity.
Supplier
Laudet Vincent, In PLoS ONE, 2009
And then the myc-SIRT1 fragment was introduced into pTRE2 vector (Clontech).
Superoxide dismutases, lung function and bronchial responsiveness in a general population
Supplier
Khachigian Levon M., In PLoS ONE, 2008
... (SOD2) antibody, anti-HuR antibody, ataxia teleangiectasia mutation (ATM) antibody, phospho-ATM antibody (Ser1981), anti-rabbit IgG and SIRT1 activator 3 from Santa Cruz Biotechnology (Santa Cruz, CA); and ...
Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APCCdh1-mediated Skp2 destruction
Supplier
Kyprianou Natasha, In PLoS ONE, 2008
... Rabbit antibodies: Emi1, Millipore; Fbx4, Rockland (Gilbertsville, PA); Fbx7, Fbx31, Novus Biologicals; Flag, Nedd8 and Sirt1, Cell Signaling; hemagglutinin (HA), Sp1 and ...
DNMT1 as a molecular target in a multimodality-resistant phenotype in tumor cells
Supplier
Berghe Wim Vanden et al., In Molecular Cancer, 2007
... Santa Cruz Biotechnology (Santa Cruz, CA), anti-p38, anti-p44/42, anti-cfos, anti-cjun, anti-junB, anti-junD from Active Motif, anti-Sirt1 from Biomol, anti-Stat3 from Upstate, anti-histone-H3 ...
Nutritional control of protein biosynthetic capacity by insulin via Myc in Drosophila.
Supplier
Kapahi Pankaj, In PLoS Genetics, 2007
... UAS-Sir2 transgenic flies were described previously ...
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Papers on Sir2
1,2,3-Triazole-Dithiocarbamate Hybrids, a Group of Novel Cell Active SIRT1 Inhibitors.
New
Liu et al., China. In Cell Physiol Biochem, Feb 2016
BACKGROUND/AIMS: Human SIRT1 is reported to be involved in tumorgenesis, mainly due to its modulating effect on p53 by deacetylation on lysine382.
Programmed Hyperphagia in Offspring of Obese Dams: Altered Expression of Hypothalamic Nutrient Sensors, Neurogenic Factors and Epigenetic Modulators.
New
Ross et al., Torrance, United States. In Appetite, Feb 2016
We determined the protein expression of energy sensors (mTOR, pAMPK), epigenetic factors (DNA methylase, DNMT1; histone deacetylase, SIRT1/HDAC1), neurogenic factors (Hes1, Mash1, Ngn3) and appetite/satiety neuropeptides (AgRP/POMC) in newborn hypothalamus and adult arcuate nucleus (ARC).
Clinicopathological significance of SIRT1 expression in colorectal cancer: a systematic review and meta analysis.
Review
New
Che et al., Dalian, China. In Int J Surg, Feb 2016
PURPOSE: The relationship between SIRT1 and clinicopathological parameters of colorectal cancer (CRC) is controversial.
[Resveratrol increases sirtuin 1 expression in peripheral blood mononuclear cells of premature infants and inhibits the oxidative stress induced by hyperoxia in vivo].
New
Zhai et al., China. In Zhongguo Dang Dai Er Ke Za Zhi, Jan 2016
OBJECTIVE: To explore the effect of resveratrol on the levels of sirtuin 1 (SIRT1) and reactive oxygen species (ROS) in peripheral blood mononuclear cells (PBMCs) of premature infants exposed to hyperoxia.
Sirtuins-mediators of maternal obesity-induced complications in offspring?
Review
New
Saad et al., Sydney, Australia. In Faseb J, Jan 2016
Sirtuins (SIRTs), particularly SIRT1 and SIRT3, are NAD(+)-dependent deacetylases that regulate metabolic balance and stress responses in both central and peripheral tissues, of which dysregulation is a well-established mediator for the development and effects of obesity.
Metformin Restores Parkin-Mediated Mitophagy, Suppressed by Cytosolic p53.
New
Lee et al., Seoul, South Korea. In Int J Mol Sci, Dec 2015
Metformin is known to alleviate hepatosteatosis by inducing 5' adenosine monophosphate (AMP)-kinase-independent, sirtuin 1 (SIRT1)-mediated autophagy.
Potential Modulation of Sirtuins by Oxidative Stress.
Review
New
Denicola et al., Montevideo, Uruguay. In Oxid Med Cell Longev, Dec 2015
Seven isoforms are identified in mammals (SIRT1-7), all of them sharing a conserved catalytic core and showing differential subcellular localization and activities.
Berberine Attenuates Myocardial Ischemia/Reperfusion Injury by Reducing Oxidative Stress and Inflammation Response: Role of Silent Information Regulator 1.
New
Yu et al., Xi'an, China. In Oxid Med Cell Longev, Dec 2015
Activation of silent information regulator 1 (SIRT1) signaling attenuates MI/R injury by reducing oxidative damage and inflammation response.
Emerging Role of Sirtuin 2 in the Regulation of Mammalian Metabolism.
Review
New
Cavadas et al., Coimbra, Portugal. In Trends Pharmacol Sci, Nov 2015
SIRT2, the predominantly cytosolic sirtuin, is among the least understood of the seven mammalian sirtuin isoforms described (SIRT1-7).
Beneficial action of resveratrol: How and why?
Review
New
Eynard et al., Córdoba, Argentina. In Nutrition, Oct 2015
This increases the cytosolic cAMP that activates Epac1/CaMKKβ/AMPK/SIRT1/PGC-1α pathway, which in turn facilitates increased oxidation of fatty acids, mitochondrial biogenesis, mitochondrial respiration, and gluconeogenesis.
The chemical biology of sirtuins.
Review
New
Impact
Zheng et al., Zhenjiang, China. In Chem Soc Rev, Sep 2015
Over the past years since the discovery of its founding member (i.e. the yeast silent information regulator 2 (sir2) protein) in 2000, the sirtuin-catalyzed deacylation reaction has been demonstrated to play an important regulatory role in multiple crucial cellular processes such as transcription, DNA damage repair, and metabolism.
NNMT: A Bad Actor in Fat Makes Good in Liver.
New
Impact
Brenner et al., Iowa City, United States. In Cell Metab, Sep 2015
Though murine NNMT knockdown in fat and liver prevents weight gain on high-fat diet, Hong et al. (2015) now show that high hepatic expression of NNMT improves lipid parameters via SIRT1 stabilization.
Sparse whole-genome sequencing identifies two loci for major depressive disorder.
New
Impact
CONVERGE consortium, In Nature, Aug 2015
Here, using low-coverage whole-genome sequencing of 5,303 Chinese women with recurrent MDD selected to reduce phenotypic heterogeneity, and 5,337 controls screened to exclude MDD, we identified, and subsequently replicated in an independent sample, two loci contributing to risk of MDD on chromosome 10: one near the SIRT1 gene (P = 2.53 × 10(-10)), the other in an intron of the LHPP gene (P = 6.45 × 10(-12)).
SIRT1-Mediated eNAMPT Secretion from Adipose Tissue Regulates Hypothalamic NAD+ and Function in Mice.
New
Impact
Imai et al., Saint Louis, United States. In Cell Metab, Jun 2015
Here we demonstrate that deacetylation of iNAMPT by the mammalian NAD(+)-dependent deacetylase SIRT1 predisposes the protein to secretion in adipocytes.
Resveratrol activates duodenal Sirt1 to reverse insulin resistance in rats through a neuronal network.
New
Impact
Lam et al., Toronto, Canada. In Nat Med, May 2015
One process that is considered a key feature of resveratrol action is the activation of the nicotinamide adenine dinucleotide (NAD(+))-dependent deacetylase sirtuin 1 (SIRT1) in various tissues.
Interactions between SIRT1 and MAPK/ERK regulate neuronal apoptosis induced by traumatic brain injury in vitro and in vivo.
GeneRIF
Fei et al., Xi'an, China. In Exp Neurol, 2012
These results reveal that SIRT1 plays a neuroprotective effect against neuronal apoptosis induced by traumatic brain injury
GATA-binding protein 4 (GATA-4) and T-cell acute leukemia 1 (TAL1) regulate myogenic differentiation and erythropoietin response via cross-talk with Sirtuin1 (Sirt1).
GeneRIF
Noguchi et al., Bethesda, United States. In J Biol Chem, 2012
a novel role for GATA-4 and TAL1 to affect skeletal myogenic differentiation and EPO response via cross-talk with Sirt1.
The acetylase/deacetylase couple CREB-binding protein/Sirtuin 1 controls hypoxia-inducible factor 2 signaling.
GeneRIF
Garcia et al., Dallas, United States. In J Biol Chem, 2012
The acetylase/deacetylase couple CREB-binding protein/Sirtuin 1 controls hypoxia-inducible factor 2 signaling.
Regulation of SIRT1 determines initial step of endometrial receptivity by controlling E-cadherin expression.
GeneRIF
Taketani et al., Tokyo, Japan. In Biochem Biophys Res Commun, 2012
these results revealed the novel mechanism that activation and increased expression of SIRT1 play an important role in uterine receptivity.
Brown remodeling of white adipose tissue by SirT1-dependent deacetylation of Pparγ.
Impact
GeneRIF
Accili et al., New York City, United States. In Cell, 2012
Study reports that SirT1-dependent Ppargamma deacetylation promotes browning of subcutaneous white adipose by regulating ligand-dependent coactivator/corepressor exchange at the Ppargamma transcriptional complex.
More papers using Sir2 antibodies
The p110delta isoform of PI 3-kinase negatively controls RhoA and PTEN
Supplier
Allinquant Bernadette, In PLoS ONE, 2006
... from Invitrogen (Carlsbad, CA); Y-27632 (4-[(1R)-1-aminoethyl]-N-pyridin-4-yl-cyclohehaxe-1-carboxamide), SP600125, TAT-TI-JIP were obtained from Calbiochem (Darmstadt, Germany), rabbit anti-SIRT1 [14], β-catenin (Santa Cruz Biotechnology Inc., Santa Cruz, CA), ...
A single siRNA suppresses fatal encephalitis induced by two different flaviviruses.
Supplier
Xu Aimin, In PLoS ONE, 2005
... Sirt1 Activator 3 (SA3) was from Cayman Chemical (Ann Arbor, MI) ...
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