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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Zinc finger E-box binding homeobox 2

SIP1, ZFHX1B, ZEB2, Gemin2
The protein encoded by this gene is a member of the Zfh1 family of 2-handed zinc finger/homeodomain proteins. It is located in the nucleus and functions as a DNA-binding transcriptional repressor that interacts with activated SMADs. Mutations in this gene are associated with Hirschsprung disease/Mowat-Wilson syndrome. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jan 2010] (from NCBI)
Top mentioned proteins: ZEB1, E-cadherin, miR, SNAIL, Slug
Papers using SIP1 antibodies
Association of arsenic-induced malignant transformation with DNA hypomethylation and aberrant gene expression.
Supplier
Yang Chengfeng et al., In Environmental Health Perspectives, 1996
... (Cell Signaling Technology, Beverly, MA, USA); anti-ZEB1 (Santa Cruz Biotechnology, Inc., Santa Cruz, CA, USA); anti-ZEB2 (Novus Biologicals, Littleton, CO, USA); and ...
Papers on SIP1
miR-200/ZEB axis regulates sensitivity to nintedanib in non-small cell lung cancer cells.
New
Gemma et al., Tokyo, Japan. In Int J Oncol, Feb 2016
PC-1R cells also showed decreased expression of miR-200b, miR-141 and miR-429 and increased expression of ZEB1 and ZEB2.
Early Infantile Epileptic Encephalopathy with a de novo variant in ZEB2 identified by exome sequencing.
New
Graham et al., Los Angeles, United States. In Eur J Med Genet, Jan 2016
We present a case of EIEE associated with a de novo missense variant in ZEB2.
[Expressions of ZEB2 and C-myc in epithelial ovarian cancer and their clinical significance].
New
Guo et al., Guangzhou, China. In Nan Fang Yi Ke Da Xue Xue Bao, Jan 2016
OBJECTIVE: To investigate the expression patterns of ZEB2 and C-myc in epithelial ovarian cancer (EOC) and the associations between their expressions and the pathological features of EOC.
A Histone Deacetylase Inhibitor Suppresses Epithelial-Mesenchymal Transition and Attenuates Chemoresistance in Biliary Tract Cancer.
New
Mori et al., Suita, Japan. In Plos One, Dec 2015
We also showed that vorinostat attenuates the binding affinity of SMAD4 to the CDH1-related transcription factors SNAI1, SNAI2, ZEB1, ZEB2, and TWIST.
Zeb2: A multifunctional regulator of nervous system development.
Review
New
O'Keeffe et al., Cork, Ireland. In Prog Neurobiol, Sep 2015
The complex nature of the Zeb2, both at its genetic and protein levels, underlie its multifunctional properties, with Zeb2 capable of acting individually or as part of a transcriptional complex to repress, and occasionally activate, target gene expression.
[Application of gene microarray to screen differential expression genes of Modic changes at vertebral endplates].
New
Cao et al., Linhai, China. In Zhonghua Yi Xue Za Zhi, Sep 2015
The qRT-PCR analysis of 2 up-regulated genes (CXCL14, KCNMA1) and 4 under-regulated genes (MARCKS, ZEB2, PSMF1, and CNN2) mRNA expression levels validated the results from the microarray analysis.
Hirschsprung's disease in children with Mowat-Wilson syndrome.
Review
New
Puri et al., Dublin, Ireland. In Pediatr Surg Int, Aug 2015
BACKGROUND: Hirschsprung's disease (HSCR) is cited as a classical component in the constellation of features found in children with Mowat-Wilson syndrome (MWS), which is caused by a mutation of the ZEB2 gene.
Dysfunction of the Reciprocal Feedback Loop between GATA3- and ZEB2-Nucleated Repression Programs Contributes to Breast Cancer Metastasis.
New
Impact
Shang et al., Beijing, China. In Cancer Cell, Jul 2015
Genome-wide analysis of the GATA3/G9A/NuRD(MTA3) targets identified a cohort of genes including ZEB2 that are critically involved in epithelial-to-mesenchymal transition and cell invasion.
A long noncoding RNA activated by TGF-β promotes the invasion-metastasis cascade in hepatocellular carcinoma.
Impact
Sun et al., Shanghai, China. In Cancer Cell, 2014
lncRNA-ATB upregulated ZEB1 and ZEB2 by competitively binding the miR-200 family and then induced EMT and invasion.
Functional Role of the microRNA-200 Family in Breast Morphogenesis and Neoplasia.
Review
Gudjonsson et al., Reykjavík, Iceland. In Genes (basel), 2013
The miR-200 family regulates epithelial morphogenesis and EMT through a negative feedback loop with the ZEB1 and ZEB2 transcription factors.
Transcription regulation of E-cadherin by zinc finger E-box binding homeobox proteins in solid tumors.
Review
Chan et al., Hong Kong, Hong Kong. In Biomed Res Int, 2013
The vertebrate zinc finger E-box binding homeobox (ZEB) protein family comprises 2 major members: ZEB1 and ZEB2.
Interactions between E-cadherin and microRNA deregulation in head and neck cancers: the potential interplay.
Review
Chan et al., Hong Kong, Hong Kong. In Biomed Res Int, 2013
Increasing evidence suggested that microRNA mediated E-cadherin expression in the head and neck cancers by directly/indirectly targeting the transcription suppressors of E-cadherin, ZEB1 and ZEB2.
A switch in the expression of embryonic EMT-inducers drives the development of malignant melanoma.
Impact
Tulchinsky et al., Lyon, France. In Cancer Cell, 2013
SNAIL2 and ZEB2 transcription factors are expressed in normal melanocytes and behave as tumor-suppressor proteins by activating an MITF-dependent melanocyte differentiation program.
Ophthalmologic abnormalities in Mowat-Wilson syndrome and a mutation in ZEB2.
GeneRIF
Traboulsi et al., Cleveland, United States. In Ophthalmic Genet, 2012
We report a 9-year-old female with this syndrome who has severe ocular abnormalities including bilateral microphthalmia, cataract, and retinal aplasia.
Onecut transcription factors act upstream of Isl1 to regulate spinal motoneuron diversification.
GeneRIF
Clotman et al., Brussels, Belgium. In Development, 2012
Sip1 (Zeb2) is a novel developmental regulator of visceral motoneuron differentiation.
Solution structure of the core SMN-Gemin2 complex.
GeneRIF
Van Duyne et al., Philadelphia, United States. In Biochem J, 2012
several conserved SMN residues, including the sites of two SMA patient mutations, are not required for binding to Gemin2. Instead, they form a conserved SMN/Gemin2 surface that may be functionally important for snRNP assembly.
miR-200c is aberrantly expressed in leiomyomas in an ethnic-dependent manner and targets ZEBs, VEGFA, TIMP2, and FBLN5.
GeneRIF
Chegini et al., Gainesville, United States. In Endocr Relat Cancer, 2012
Altered expression of miR-200c may have a significant impact on the outcome of leiomyomas growth, maintenance of their mesenchymal and fibrotic characteristics, and possibly their associated symptoms.
The transcription factor Zeb2 regulates signaling in mast cells.
GeneRIF
Siraganian et al., Bethesda, United States. In J Immunol, 2012
The results indicate that the transcription factor Zeb2 controls the expression of molecules thereby regulating signaling in mast cells.
In vivo identification of tumor- suppressive PTEN ceRNAs in an oncogenic BRAF-induced mouse model of melanoma.
Impact
GeneRIF
Pandolfi et al., Boston, United States. In Cell, 2011
Study genetically identifies multiple putative microRNA decoys for PTEN, validates ZEB2 mRNA as a bona fide PTEN ceRNA, and demonstrates that abrogated ZEB2 expression cooperates with BRAF(V600E) to promote melanomagenesis.
SIP1 mediates cell-fate decisions between neuroectoderm and mesendoderm in human pluripotent stem cells.
Impact
GeneRIF
Vallier et al., Cambridge, United Kingdom. In Cell Stem Cell, 2010
demonstrate that Smad-interacting protein 1 (SIP1) limits the mesendoderm-inducing effects of Activin-Nodal signaling without inhibiting the pluripotency-maintaining effects exerted by SMAD2/3.
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