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Tumor protein p53 inducible nuclear protein 1

Sip, CacyBP, TP53INP1, TEAP, p53DINP1
This gene encodes a ribonucleoprotein that functions as a general nuclear coactivator, and an RNA splicing modulator. This protein contains two RNA recognition motifs (RRM) at the N-terminus, and multiple hexapeptide repeat domain at the C-terminus that interacts with thyroid hormone receptor-binding protein (TRBP), and is required for transcription activation. Alternatively spliced transcript variants encoding different isoforms (with opposing effects on transcription) have been described for this gene. [provided by RefSeq, Oct 2011] (from NCBI)
Top mentioned proteins: p53, calcyclin, miR, CAN, Siah-1
Papers on Sip
Lower Prevalence of Alzheimer's Disease among Tibetans: Association with Religious and Genetic Factors.
New
Hu et al., Beijing, China. In J Alzheimers Dis, Feb 2016
MALDI-TOF was used to test the genotypes of CLU, TFAM, TP53INP1, IGHV1-67, CR1, ApoE, and BIN1.
A positive feedback loop of p53/miR-19/TP53INP1 modulates pancreatic cancer cell proliferation and apoptosis.
New
Wang et al., Xinxiang, China. In Oncol Rep, Jan 2016
Additionally, p53 is able to activate TP53INP1 transcription by regulating several phenotypes of cancer cells.
Silencing of CD24 enhances the PRIMA-1-induced restoration of mutant p53 in prostate cancer cells.
New
Liu et al., Birmingham, United States. In Clin Cancer Res, Jan 2016
Silencing of CD24 increased the transcriptional activity of p53 target genes, such as CDKNA1, VDR, and TP53INP1, leading to suppression of p53-dependent cell growth, cell cycle arrest, and apoptosis in most TP53-mutant PCa cells.
Expression and regulation of CacyBP/SIP in chronic lymphocytic leukemia cell balances of cell proliferation with apoptosis.
New
Xu et al., Xuzhou, China. In J Cancer Res Clin Oncol, Dec 2015
The calcyclin-binding protein/Siah-1-interacting protein (CacyBP/SIP) plays a pivotal role in tumorigenicity and cell apoptosis.
MiR-155 Knockout in Fibroblasts Improves Cardiac Remodeling by Targeting Tumor Protein p53-Inducible Nuclear Protein 1.
New
Xiao et al., Wuhan, China. In J Cardiovasc Pharmacol Ther, Dec 2015
In addition, downregulation of tumor protein p53-inducible nuclear protein 1 (TP53INP1) by small interfering RNA reverses the effects of miR-155 knockout on cardiac fibroblasts.
The stress protein TP53INP1 plays a tumor suppressive role by regulating metabolic homeostasis.
Review
New
Carrier et al., Marseille, France. In Biochimie, Nov 2015
In the recent years, we have provided evidence that Tumor Protein 53-Induced Nuclear Protein 1 (TP53INP1) is a key stress protein with antioxidant-associated tumor suppressive function.
Copy number gain of hsa-miR-569 at 3q26.2 leads to loss of TP53INP1 and aggressiveness of epithelial cancers.
Impact
Mills et al., Houston, United States. In Cancer Cell, 2015
Downregulation of TP53INP1 expression by miR569 is required for the effects of miR569 on survival and proliferation.
Genetic polymorphisms in apoptosis-related genes and the prognosis of hepatocellular carcinoma.
Jiang et al., Shanghai, China. In Am J Cancer Res, 2014
We genotyped 16 single nucleotide polymorphisms (SNPs) in 10 core genes (TP53, TP53INP1, TP53BP1, CDKN2A, CDKN1A, CDKN1B, MDM2, BAX, CCDN1 and BCL2) in the apoptotic pathway by using DNA from blood samples of 362 HCC patients receiving surgical resection of HCC tumor.
Epigenetic regulation of the DLK1-MEG3 microRNA cluster in human type 2 diabetic islets.
Impact
Kaestner et al., Philadelphia, United States. In Cell Metab, 2014
Using HITS-CLIP for the essential RISC-component Argonaute, we identified disease-relevant targets of the chromosome 14q32 microRNAs, such as IAPP and TP53INP1, that cause increased β cell apoptosis upon overexpression in human islets.
Bacillus thuringiensis toxins: an overview of their biocidal activity.
Review
Caballero et al., Spain. In Toxins (basel), 2013
A less well characterized secretory protein with no amino acid similarity to Vip proteins has shown insecticidal activity against coleopteran pests and is termed Sip (secreted insecticidal protein).
TP53INP1 as new therapeutic target in castration-resistant prostate cancer.
GeneRIF
Rocchi et al., Marseille, France. In Prostate, 2012
TP53INP1 antisense oligonucleotide inhibits proliferation and induces apoptosis in castration-sensitive LNCaP tumor cells.
CacyBP/SIP phosphatase activity in neuroblastoma NB2a and colon cancer HCT116 cells.
GeneRIF
Filipek et al., Warsaw, Poland. In Biochem Cell Biol, 2012
different activity of CacyBP/SIP in neuroblastoma NB2a and colon cancer HCT116 cells might affect the ERK1/2 pathway in the differentiation or proliferation processes
Sipuleucel-T (Provenge) autologous vaccine approved for treatment of men with asymptomatic or minimally symptomatic castrate-resistant metastatic prostate cancer.
Review
Hahn et al., Indianapolis, United States. In Hum Vaccin Immunother, 2012
Sipuleucel-T (Provenge) (Sip-T) is first -in class as a therapeutic autologous vaccine approved for the treatment of men with asymptomatic or minimally symptomatic castrate-resistant metastatic prostate cancer.
Survival of pancreatic beta cells is partly controlled by a TCF7L2-p53-p53INP1-dependent pathway.
GeneRIF
Hansson et al., Malmö, Sweden. In Hum Mol Genet, 2012
Survival of pancreatic beta cells is partly controlled by a TCF7L2-p53-Tp53INP1-dependent pathway.
S100A6 protein negatively regulates CacyBP/SIP-mediated inhibition of gastric cancer cell proliferation and tumorigenesis.
GeneRIF
Wang et al., Xi'an, China. In Plos One, 2011
new insight into the interaction between S100 proteins and CacyBP/SIP
DOR/Tp53inp2 and Tp53inp1 constitute a metazoan gene family encoding dual regulators of autophagy and transcription.
GeneRIF
Zorzano et al., Barcelona, Spain. In Plos One, 2011
TP53INP1 identified two conserved regions in the DOR family that concentrate multiple functions crucial for autophagy and transcription.
S100A6 binding protein and Siah-1 interacting protein (CacyBP/SIP): spotlight on properties and cellular function.
Review
Filipek et al., Warsaw, Poland. In Amino Acids, 2011
The CacyBP/SIP protein (S100A6 binding protein and Siah-1 interacting protein) was originally discovered in Ehrlich ascites tumor cells as a S100A6 (calcyclin) target (Filipek and Wojda in Biochem J 320:585-587, 1996; Filipek and Kuźnicki in J Neurochem 70(5):1793-1798, 1998) and later on as a Siah-1 interacting protein (Matsuzawa and Reed in Mol Cell 7(5):915-926, 2001).
miR-130b Promotes CD133(+) liver tumor-initiating cell growth and self-renewal via tumor protein 53-induced nuclear protein 1.
Impact
Guan et al., Hong Kong, Hong Kong. In Cell Stem Cell, 2011
The increased miR-130b paralleled the reduced TP53INP1, a known miR-130b target.
Mutant mouse models of oxidative stress.
Review
Carrier et al., Marseille, France. In Transgenic Res, 2010
Mice deficient either for the stress factor TP53INP1, which is a target of p53, or for ATM involved in DNA damage sensoring, also show a constitutive oxidative stress.
Critical function for SIP, a ubiquitin E3 ligase component of the beta-catenin degradation pathway, for thymocyte development and G1 checkpoint.
Impact
GeneRIF
Matsuzawa et al., Los Angeles, United States. In Immunity, 2006
SIP (CacyBP)-thymocytes have an impaired pre-TCR checkpoint with failure of TCRbeta gene rearrangement and increased apoptosis, resulting in reduced cellularity of the thymus.
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