Genetic polymorphisms in apoptosis-related genes and the prognosis of hepatocellular carcinoma.
Shanghai, China. In Am J Cancer Res, 2014
We genotyped 16 single nucleotide polymorphisms (SNPs) in 10 core genes (TP53, TP53INP1, TP53BP1, CDKN2A, CDKN1A, CDKN1B, MDM2, BAX, CCDN1 and BCL2) in the apoptotic pathway by using DNA from blood samples of 362 HCC patients receiving surgical resection of HCC tumor.
Mutant mouse models of oxidative stress.
Marseille, France. In Transgenic Res, 2010
Mice deficient either for the stress factor TP53INP1, which is a target of p53, or for ATM involved in DNA damage sensoring, also show a constitutive oxidative stress.