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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Embryonal Fyn-associated substrate

Sin
The protein encoded by this gene contains a SH3 domain, which is known to be important in intracellular signal transduction. The protein encoded by a similiar gene in mice was shown to be able to bind to SH3 domain of protein-tyrosine kinases. The function of this gene is unknown. Two alternatively spliced variants have been described. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, V1a, HAD, ACID, iNOS
Papers using Sin antibodies
Riluzole protects against glutamate-induced slowing of neurofilament axonal transport
Supplier
White Anthony R et al., In Molecular Neurodegeneration, 2008
... N'-dimethyl-4,4'-bipyridinium dichloride (paraquat), rotenone, 1-methyl-4-phenylpyridinium (MPP+), sodium azide, sodium arsenite, 3-nitropropionic acid (3-NP) and 3-Morpholinosyndnomine (SIN-1) were from Sigma Aldrich (Sydney, NSW, Australia) and ...
Troglitazone induces GLUT4 translocation in L6 myotubes.
Supplier
Parise Gianni, In PLoS ONE, 2000
... Ang II was from Bachem, myricetin, SIN-1 and nitro-l-arginine-methyl-ester (l-NAME) from Cayman, insulin and 3-nitrotyrosine were ...
Bcl-2 prevents nitric oxide-mediated apoptosis and poly(ADP-ribose) polymerase cleavage
Supplier
Porter Alan G. et al., In Nucleic Acids Research, 1996
... SNP, DETA-NO, SIN-1 and other chemicals were obtained from Sigma Aldrich.
Papers on Sin
Intra-articular delivery of sinomenium encapsulated by chitosan microspheres and photo-crosslinked GelMA hydrogel ameliorates osteoarthritis by effectively regulating autophagy.
New
Fan et al., Hangzhou, China. In Biomaterials, Mar 2016
The present study aimed to investigate the synergistic therapeutic effect of promotion of chondrocyte autophagy via exposure to sinomenium (SIN) encapsulated by chitosan microspheres (CM-SIN) and photo-crosslinked gelatin methacrylate (GelMA) hydrogel, with the goal of evaluating CM-SIN as a treatment for patients with osteoarthritis.
Aged Garlic Extract Inhibits Human Platelet Aggregation by Altering Intracellular Signaling and Platelet Shape Change.
New
Smith et al., Liverpool, United Kingdom. In J Nutr, Feb 2016
Platelet aggregation was induced by ADP in the presence of AGE up to a concentration of 6.25% (vol:vol) alone or in combination with 3-morpholinosydnonimine (Sin-1), a nitric oxide donor.
Multicenter clinical trial of the Nucleus Hybrid S8 cochlear implant: Final outcomes.
New
Turner et al., Seattle, United States. In Laryngoscope, Feb 2016
The majority had improvements with BKB-SIN.
Chronic Granulomatous Disease: clinical, molecular and therapeutic aspects.
Review
New
Finocchi et al., Roma, Italy. In Pediatr Allergy Immunol, Jan 2016
After the failure of the first trials performed with retroviral vectors, some groups have proposed the use of regulated SIN-lentiviral vectors targeting gp91(phox) expression in myeloid cells to increase the safety and efficacy of the GT-protocols.
Embryonal Fyn-associated substrate (EFS) and CASS4: The lesser-known CAS protein family members.
Review
New
Golemis et al., Philadelphia, United States. In Gene, Nov 2015
The CAS (Crk-associated substrate) adaptor protein family consists of four members: CASS1/BCAR1/p130Cas, CASS2/NEDD9/HEF1/Cas-L, CASS3/EFS/Sin and CASS4/HEPL.
[Direct interactions between human mesenchymal stem cells and ovarian cancer cells].
New
Tong et al., Shanghai, China. In Zhonghua Yi Xue Za Zhi, Jul 2015
METHODS: MSC and ovarian cancer cells of SK-OV-3, NIH:OVCAR-3 and SCCOHT-1 were transfected with third-generation lentiviral self-inactivating (SIN) vector containing enhanced green fluorescent protein (eGFP) or mCherry gene.
Pombe's thirteen - control of fission yeast cell division by the septation initiation network.
Review
New
Simanis, Lausanne, Switzerland. In J Cell Sci, May 2015
The septation initiation network (SIN) regulates aspects of cell growth and division in Schizosaccharomyces pombe and is essential for cytokinesis.
Amino acid interaction networks provide a new lens for therapeutic antibody discovery and anti-viral drug optimization.
Review
New
Babcock et al., Cambridge, United States. In Curr Opin Virol, Apr 2015
Calculation of a significant interaction network (SIN) score allows for selection of amino acids that are conserved and constrained within the protein system.
Clinical applications of gene therapy for primary immunodeficiencies.
Review
New
Aiuti et al., Milano, Italy. In Hum Gene Ther, Apr 2015
On the other hand, the occurrence of insertional oncogenesis in SCID-X1, WAS, and chronic granulomatous disease (CGD) RV clinical trials prompted the development of safer vector construct based on self-inactivating (SIN) retroviral or lentiviral vectors (LVs).
Effect of sinomenine on the expression of rheumatoid arthritis fibroblast-like synoviocytes MyD88 and TRAF6.
Chen et al., Changchun, China. In Genet Mol Res, 2014
The effect of sinomenine (SIN) on the toll-like receptor (TLR) signal transduction pathway as well as the expression of myeloid differentiation factor 88 (MyD88) and tumor necrosis factor (TNF) receptor-associated factor-6 (TRAF6) was investigated.
A modified γ-retrovirus vector for X-linked severe combined immunodeficiency.
Impact
Thrasher et al., London, United Kingdom. In N Engl J Med, 2014
METHODS: We enrolled nine boys with SCID-X1 in parallel trials in Europe and the United States to evaluate treatment with a self-inactivating (SIN) γ-retrovirus vector containing deletions in viral enhancer sequences expressing γc (SIN-γc).
The S. pombe cytokinesis NDR kinase Sid2 activates Fin1 NIMA kinase to control mitotic commitment through Pom1/Wee1.
Impact
Hagan et al., Manchester, United Kingdom. In Nat Cell Biol, 2012
The mitotic exit network (MEN) of budding yeast regulates both processes, whereas the fission yeast equivalent, the septum initiation network (SIN), controls only the execution of cytokinesis.
EFS shows biallelic methylation in uveal melanoma with poor prognosis as well as tissue-specific methylation.
GeneRIF
Zeschnigk et al., Essen, Germany. In Bmc Cancer, 2010
Analysis of 16 Uveal melanoma showed full methylation of the EFS CpG island in 8 (50%), no methylation in 5(31%)and partial methylation in 3 (19%)tumors. Kaplan-Meier analysis revealed higher risk of metastatic progression for tumors with EFS methylation.
Regulation of cytokinesis by spindle-pole bodies.
Impact
Khodjakov et al., Albany, United States. In Nat Cell Biol, 2006
In the fission yeast Schizosaccharomyces pombe, cytokinesis is thought to be controlled by the daughter spindle-pole body (SPB) through a regulatory pathway named the septation initiation network (SIN).
Deficiency in expression of the signaling protein Sin/Efs leads to T-lymphocyte activation and mucosal inflammation.
GeneRIF
Alexandropoulos et al., New York City, United States. In Mol Cell Biol, 2005
Sin-deficient mice exhibit exaggerated immune responses characterized by enhanced cytokine secretion and T-cell-dependent antibody production.
Characterization of human RNA polymerase III identifies orthologues for Saccharomyces cerevisiae RNA polymerase III subunits.
GeneRIF
Hernandez et al., Stony Brook, United States. In Mol Cell Biol, 2002
Data describe the purification and identification of RNA polymerase III subunits RPC2 and RPC5.
A high-throughput alphavirus-based expression cloning system for mammalian cells.
Impact
Bachmann et al., Zürich, Switzerland. In Nat Biotechnol, 2001
Complementary DNA (cDNA) libraries were expressed in mammalian cells following infection with recombinant Sindbis virus (SIN replicon particles), a member of the Alphavirus genus.
Activation of the yeast HO gene by release from multiple negative controls.
Impact
Herskowitz et al., In Cell, 1987
We present evidence that some SWI products activate HO by antagonizing negative regulatory activities encoded by the SIN genes.
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