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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Lipopolysaccharide-induced TNF factor

SIMPLE
Lipopolysaccharide is a potent stimulator of monocytes and macrophages, causing secretion of tumor necrosis factor-alpha (TNF-alpha) and other inflammatory mediators. This gene encodes lipopolysaccharide-induced TNF-alpha factor, which is a DNA-binding protein and can mediate the TNF-alpha expression by direct binding to the promoter region of the TNF-alpha gene. The transcription of this gene is induced by tumor suppresor p53 and has been implicated in the p53-induced apoptotic pathway. Mutations in this gene cause Charcot-Marie-Tooth disease type 1C (CMT1C) and may be involved in the carcinogenesis of extramammary Paget's disease (EMPD). Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, OUT, AGE, ACID
Papers on SIMPLE
Insulin degludec/insulin aspart once daily in Type 2 diabetes: a comparison of simple or stepwise titration algorithms (BOOST(®) : SIMPLE USE).
New
de la Rosa et al., Seoul, South Korea. In Diabet Med, Feb 2016
The Simple algorithm titrated IDegAsp twice weekly based on a single pre-breakfast self-monitored plasma glucose (SMPG) measurement.
PHARMACOLOGICAL REGULATION OF DIGESTION IN THE ANAUTOGENOUS FLESH FLY, Sarcophaga crassipalpis, BY SIMPLE INJECTION OF 6-HYDROXYDOPAMINE.
New
Huybrechts et al., Leuven, Belgium. In Arch Insect Biochem Physiol, Feb 2016
UNASSIGNED: Female anautogenous Sarcophaga flesh flies need a protein meal to start large-scale yolk polypeptides (YPs) production and oocyte maturation.
TREATMENT INTENSIFICATION WITH IDEGASP TWICE DAILY: RANDOMIZED STUDY TO COMPARE A SIMPLE OR A STEP-WISE TITRATION ALGORITHM.
New
Behnke et al., Albany, United States. In Endocr Pract, Jan 2016
OBJECTIVE: This 26-week, multicenter, randomized, open-label, parallel-group, treat-to-target trial in adults with type 2 diabetes compared the efficacy and safety of treatment intensification algorithms with twice-daily (BID) insulin degludec/insulin aspart (IDegAsp).
[PREPUBERTAL MATURE TERATOMA OF THE TESTIS MASQUERADING OF A SIMPLE CYST OF THE TESTIS].
Review
New
Kawauchi et al., In Nihon Hinyokika Gakkai Zasshi, Oct 2015
Although we suspected a simple cyst of the testis or a benign testicular tumor, the left testicle was explored via an inguinal incision in case of malignancy.
SIMPLE, SENSITIVE AND SELECTIVE SPECTROPHOTOMETRIC ASSAY OF NAPROXEN IN PURE, PHARMACEUTICAL PREPARATION AND HUMAN SERUM SAMPLES.
New
Keyhanian et al., In Acta Pol Pharm, Sep 2015
Two simple, rapid and sensitive spectrophotometric methods have been developed for the determination of naproxen in pure, pharmaceutical preparation and human serum samples.
[10 YEARS' EXPERIENCE IN USING DIRECT URETEROINTESTINAL ANASTOMOSIS IN URINARY INTESTINAL DIVERSION AFTER RADICAL AND SIMPLE CYSTECTOMY].
New
Guspanov et al., In Urologiia, Jul 2015
147 patients who underwent urinary intestinal diversion from 2004 to 2014 were selected for the retrospective study.
Cardioverter defibrillator implantation without induction of ventricular fibrillation: a single-blind, non-inferiority, randomised controlled trial (SIMPLE).
New
Impact
Shockless IMPLant Evaluation [SIMPLE] investigators et al., Hamilton, Canada. In Lancet, Mar 2015
BACKGROUND: Defibrillation testing by induction and termination of ventricular fibrillation is widely done at the time of implantation of implantable cardioverter defibrillators (ICDs).
The conditional-recency dissociation is confounded with nominal recency: should unitary models of memory still be devaluated?
Review
Goshen-Gottstein et al., Tel Aviv-Yafo, Israel. In Psychon Bull Rev, 2014
This dissociation challenges temporal context TCM; Howard & Kahana (Journal of Mathematical Psychology, 46, 269-299, 2002) and distinctiveness SIMPLE; Brown, Neath, & Chater (Psychological Review, 114, 539-576, 2007) unitary models of memory and suggests the involvement of a short-term buffer in immediate FR.
Flexibility within the middle ears of vertebrates.
Review
Farr et al., Cambridge, United Kingdom. In J Laryngol Otol, 2013
SIMPLE MODELS: Simple models suggest that flexibility will generally reduce the transmission of sound energy through the middle ear, although in certain theoretical situations flexibility within or between conducting elements might improve transmission.
PIG7, transactivated by AML1, promotes apoptosis and differentiation of leukemia cells with AML1-ETO fusion gene.
GeneRIF
Wang et al., Tianjin, China. In Leukemia, 2012
PIG7 could be transactivated by AML1, which subsequently induces differentiation and apoptosis of leukemia cells, especially those with AML1-ETO fusion gene
Mutations associated with Charcot-Marie-Tooth disease cause SIMPLE protein mislocalization and degradation by the proteasome and aggresome-autophagy pathways.
GeneRIF
Li et al., Atlanta, United States. In J Cell Sci, 2011
Our findings suggest that SIMPLE mutations cause Charcot-Marie-Tooth type 1 C peripheral neuropathy by a combination of loss-of-function and toxic gain-of-function mechanisms
LITAF and TNFSF15, two downstream targets of AMPK, exert inhibitory effects on tumor growth.
GeneRIF
Luo et al., Boston, United States. In Oncogene, 2011
studies for the first time establish the regulatory axis of AMPK-LITAF-TNFSF15 and also suggest that LITAF may function as a tumor suppressor
A new tumor necrosis factor (TNF)-α regulator, lipopolysaccharides-induced TNF-α factor, is associated with obesity and insulin resistance.
GeneRIF
Xu et al., Wuhan, China. In Chin Med J (engl), 2011
LITAF is associated with obesity and insulin resistance, as well as inflammatory cytokine secretion. The results indicate LITAF to be a new mediator between inflammation and the obesity related disorders.
SIMPLE/LITAF expression induces the translocation of the ubiquitin ligase itch towards the lysosomal compartments.
GeneRIF
Brunetti et al., Peterborough, Canada. In Plos One, 2010
Itch protein re-localization is dependent upon the interaction with the PPXY sequences of LITAF, since disruption of these binding motifs completely abrogates Itch re-localization.
Scale-invariant and locally distinctive memory: the SIMPLE approach.
Review
Harvey, Winchester, United Kingdom. In Trends Cogn Sci, 2008
A new formal model of scale-invariant memory and perceptual identification, SIMPLE, accounts for a wide range of data over short and long time scales using the same basic retrieval principles.
Schwann cells and the pathogenesis of inherited motor and sensory neuropathies (Charcot-Marie-Tooth disease).
Review
Suter et al., Zürich, Switzerland. In Glia, 2006
These include the myotubularin-related lipid phosphatase MTMR2 and its regulatory binding partner MTMR13/SBF2, SIMPLE, and potentially also dynamin 2. Mutations affecting the mitochondrial fission factor GDAP1 may indicate an important contribution of mitochondria in myelination or myelin maintenance, whereas the functions of other identified genes, including NDRG1, KIAA1985, and the tyrosyl-tRNA synthase YARS, are not yet clear.
STRYCHNINE: ITS FACILITATING EFFECT ON THE SOLUTION OF A SIMPLE ODDITY PROBLEM BY THE RAT.
Impact
HUDSPETH, In Science, 1964
The learning of a brightness discrimination, discrimination reversal, and a simple oddity problem by rats was facilitated when the rats were given injections of strychnine sulfate after daily training sessions.
IMMUNOLOGICAL TOLERANCE INDUCED IN ANIMALS PREVIOUSLY SENSITIZED TO SIMPLE CHEMICAL COMPOUNDS.
Impact
DEWECK et al., In Science, 1964
Adult guinea pigs develop a delayed hypersensitivity to intradermally injected neoarsphenamine.
CHLORAMPHENICOL IN BLOOD: SIMPLE CHEMICAL ESTIMATIONS IN PATIENTS RECEIVING MULTIPLE ANTIBIOTICS.
Impact
DIAMOND et al., In Science, 1964
A simple method is described which obviates the difficulties of estimating the concentration of chloramphenicol in the blood in the presence of other antibiotics.
A SIMPLE MEMBRANE MANOMETER.
Impact
Gregory et al., In Science, 1925
The abdominal aorta of small mammals is easy of access, and this vessel is well suited for the taking of blood pressure tracings having a good amplitude of pulsation.
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