Hypoactivity following perturbed estrogen signaling in the medial amygdala.
In J Clin Invest, Aug 2015
In this issue of the JCI, Xu and colleagues provide extensive evidence that ERα is abundant on neurons expressing single-minded-1 (SIM1) in the medial amygdala (MeA) and that loss of ERα in these cells enhances weight gain in both male and female mice, as the result of reduced physical activity.
Neuropathologic research strategies in holoprosencephaly.
Seattle, United States. In J Child Neurol, 2001
Secondary down-regulation of the OTP gene or of downstream genes such as BRN2 or SIM1 may result in failure of terminal differentiation of magnocellular neurons of the supraoptic and paraventricular hypothalamic nuclei.
Remembrance of things PAS: regulation of development by bHLH-PAS proteins.
Chapel Hill, United States. In Curr Opin Genet Dev, 1999
Recent studies using mouse knockouts of bHLH-PAS genes have provided novel insight into the roles of hypoxia inducible factors in controlling oxygen-regulated development and homeostasis, and the role of Single-minded-1 in regulating development and transcription in the hypothalamus.