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Stromal interaction molecule 1

Sim, STIM1, stromal interaction molecule 1, SIM2
This gene encodes a type 1 transmembrane protein that mediates Ca2+ influx after depletion of intracellular Ca2+ stores by gating of store-operated Ca2+ influx channels (SOCs). It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region, as well as early hematopoiesis, by mediating attachment to stromal cells. This gene is oriented in a head-to-tail configuration with the ribonucleotide reductase 1 gene (RRM1), with the 3' end of this gene situated 1.6 kb from the 5' end of the RRM1 gene.[provided by RefSeq, Jan 2009] (from NCBI)
Top mentioned proteins: Orai1, HIF-1alpha, V1a, CAN, STIM2
Papers using Sim antibodies
Ca2+ store depletion causes STIM1 to accumulate in ER regions closely associated with the plasma membrane
Supplier
Lewis Richard S. et al., In The Journal of Cell Biology, 1994
... inserting EGFP or HRP at amino acid 39, just after the signal sequence of human STIM1 in pCMV6-XL5 (Origene).
Coupling Ca2+ store release to Icrac channel activation in B lymphocytes requires the activity of Lyn and Syk kinases
Supplier
Korenbrot Juan I. et al., In The Journal of Cell Biology, 1992
... The STIM1 antibody was purchased from BD Biosciences.
Papers on Sim
A stromal interaction molecule1 variant up-regulates matrix metalloproteinase-2 expression by strengthening nucleoplasmic Ca(2+) signaling.
New
Hu et al., China. In Biochim Biophys Acta, Feb 2016
UNASSIGNED: Very recent studies hold promise to reveal the role of stromal interaction molecule 1 (STIM1) in non-store-operated Ca(2+) entry.
RefSOFI for Mapping Nanoscale Organization of Protein-Protein Interactions in Living Cells.
New
Zhang et al., San Diego, United States. In Cell Rep, Feb 2016
Using this strategy, termed reconstituted fluorescence-based SOFI (refSOFI), we investigated the interaction between the endoplasmic reticulum (ER) Ca(2+) sensor STIM1 and the pore-forming channel subunit ORAI1, a crucial process in store-operated Ca(2+) entry (SOCE).
Epithelial- mesenchymal transition, IP3 receptors and ER-PM junctions: translocation of Ca2+ signalling complexes and regulation of migration.
New
Tepikin et al., Liverpool, United Kingdom. In Biochem J, Feb 2016
We observed a dramatic redistribution of IP3Rs and STIM1-competent ER-PM junctions when pancreatic ductal adenocarcinoma (PDAC) cells disconnect from their neighbours and undergo individual migration.
S. cerevisiae Mre11 recruits conjugated SUMO moieties to facilitate the assembly and function of the Mre11-Rad50-Xrs2 complex.
New
Wang et al., Taipei, Taiwan. In Nucleic Acids Res, Feb 2016
Mre11 has two evolutionarily-conserved SUMO-interacting motifs, Mre11(SIM1) and Mre11(SIM2), which reside on the outermost surface of Mre11.
ORAI Channel-Mediated Ca2+ Signals in Vascular and Airway Smooth Muscle.
Review
New
Trebak et al., United States. In Am J Physiol Cell Physiol, Jan 2016
UNASSIGNED: Orai proteins (Orai1-3) form a family of highly Ca(2+) selective plasma membrane channels that are regulated by stromal interacting molecules (STIM1 and STIM2); STIM proteins are Ca(2+) sensors located in the membrane of the endoplasmic reticulum (ER).
The Shine-Dalgarno sequence of riboswitch-regulated single mRNAs shows ligand-dependent accessibility bursts.
New
Walter et al., Ann Arbor, United States. In Nat Commun, Dec 2015
Here we develop Single Molecule Kinetic Analysis of RNA Transient Structure (SiM-KARTS) to investigate the ligand-dependent accessibility of the SD sequence of an mRNA hosting the 7-aminomethyl-7-deazaguanine (preQ1)-sensing riboswitch.
Diseases caused by mutations in ORAI1 and STIM1.
Review
New
Feske et al., New York City, United States. In Ann N Y Acad Sci, Nov 2015
Loss- and gain-of-function gene mutations in ORAI1 and STIM1 in human patients cause distinct disease syndromes.
Kaposi Sarcoma of Childhood: Inborn or Acquired Immunodeficiency to Oncogenic HHV-8.
Review
New
Casanova et al., Paris, France. In Pediatr Blood Cancer, Nov 2015
Recent studies have shown that classic KS of childhood can result from rare single-gene inborn errors of immunity, with mutations in WAS, IFNGR1, STIM1, and TNFRSF4.
STIM and calcium channel complexes in cancer.
Review
New
Rosado et al., Cáceres, Spain. In Biochim Biophys Acta, Nov 2015
The Ca(2+)-selective store-operated current (ICRAC) is mediated by the endoplasmic reticulum (ER) Ca(2+) sensor STIM1 and the store-operated Ca(2+) (SOC) channel Orai1, while other non-selective cation currents (ISOC) involves the participation of members of the canonical transient receptor potential (TRPC) channel family, including TRPC1.
STIMATE reveals a STIM1 transitional state.
New
Impact
Soboloff et al., Philadelphia, United States. In Nat Cell Biol, Oct 2015
Decreases in endoplasmic reticulum calcium content are sensed by resident STIM proteins, which can activate plasma membrane Orai channels to facilitate Ca(2+) entry.
Proteomic mapping of ER-PM junctions identifies STIMATE as a regulator of Ca²⁺ influx.
New
Impact
Zhou et al., Houston, United States. In Nat Cell Biol, Oct 2015
Store-operated Ca(2+) entry mediated by dynamic STIM1-ORAI1 coupling represents a classical molecular event occurring at ER-PM junctions, but the protein composition and how previously unrecognized protein regulators facilitate this process remain ill-defined.
Optogenetic control of endogenous Ca(2+) channels in vivo.
New
Impact
Heo et al., Taejŏn, South Korea. In Nat Biotechnol, Oct 2015
Using OptoSTIM1, which combines a plant photoreceptor and the CRAC channel regulator STIM1 (ref.
The Role of the Neuroprotective Factor Npas4 in Cerebral Ischemia.
Review
Lewis et al., Adelaide, Australia. In Int J Mol Sci, 2014
Neuronal Per-Arnt-Sim domain protein 4 (Npas4) is an activity-dependent transcription factor whose expression is induced in various brain insults, including cerebral ischemia.
The aryl hydrocarbon receptor in barrier organ physiology, immunology, and toxicology.
Review
Impact
Rannug et al., Düsseldorf, Germany. In Pharmacol Rev, 2014
The aryl hydrocarbon receptor (AhR) is an evolutionarily old transcription factor belonging to the Per-ARNT-Sim-basic helix-loop-helix protein family.
Interactive features of proteins composing eukaryotic circadian clocks.
Review
Impact
Young et al., Ithaca, United States. In Annu Rev Biochem, 2013
A series of clock protein structures demonstrate that the PAS (Per/Arnt/Sim) domain has been used with great variation to formulate the transcriptional activators and repressors of the clock.
STIM1 is necessary for store-operated calcium entry in turning growth cones.
GeneRIF
Foa et al., Hobart, Australia. In J Neurochem, 2012
STIM1 is essential for correct growth cone navigation and plays multiple roles in growth cone motility, including activation of store-operated calcium entry (SOCE).
STIM proteins: dynamic calcium signal transducers.
Impact
GeneRIF
Gill et al., Philadelphia, United States. In Nat Rev Mol Cell Biol, 2012
Studies indicate that in vertebrates, stromal interaction molecule proteins STIM1 and STIM2 are expressed ubiquitously throughout cell types.
Polyamines regulate intestinal epithelial restitution through TRPC1-mediated Ca²+ signaling by differentially modulating STIM1 and STIM2.
GeneRIF
Wang et al., Baltimore, United States. In Am J Physiol Cell Physiol, 2012
It was shown that polyamines regulate intestinal epithelial restitution through TRPC1-mediated Ca2+ signaling by altering the ratio of STIM1 to STIM2. Overexpression of ornithine decarboxylase resulted in increased STIM1 but decreased STIM2 expression.
STIM1-Ca(2+) signaling is required for the hypertrophic growth of skeletal muscle in mice.
GeneRIF
Rosenberg et al., Durham, United States. In Mol Cell Biol, 2012
model proposed wherein STIM1-mediated store-operated calcium entry governs the Ca(2 ) signaling required for cellular processes that are necessary for neonatal muscle growth and differentiation
Surf4 modulates STIM1-dependent calcium entry.
GeneRIF
Baba et al., Yokohama, Japan. In Biochem Biophys Res Commun, 2012
These findings suggest the modulatory function of Surf4 for STIM1-mediated store-operated Ca(2+) entry.
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