ORAI Channel-Mediated Ca2+ Signals in Vascular and Airway Smooth Muscle.
United States. In Am J Physiol Cell Physiol, Jan 2016
UNASSIGNED: Orai proteins (Orai1-3) form a family of highly Ca(2+) selective plasma membrane channels that are regulated by stromal interacting molecules (STIM1 and STIM2); STIM proteins are Ca(2+) sensors located in the membrane of the endoplasmic reticulum (ER).
STIM and calcium channel complexes in cancer.
Cáceres, Spain. In Biochim Biophys Acta, Nov 2015
The Ca(2+)-selective store-operated current (ICRAC) is mediated by the endoplasmic reticulum (ER) Ca(2+) sensor STIM1 and the store-operated Ca(2+) (SOC) channel Orai1, while other non-selective cation currents (ISOC) involves the participation of members of the canonical transient receptor potential (TRPC) channel family, including TRPC1.
STIMATE reveals a STIM1 transitional state.
Philadelphia, United States. In Nat Cell Biol, Oct 2015
Decreases in endoplasmic reticulum calcium content are sensed by resident STIM proteins, which can activate plasma membrane Orai channels to facilitate Ca(2+) entry.
STIM proteins: dynamic calcium signal transducers.
Philadelphia, United States. In Nat Rev Mol Cell Biol, 2012
Studies indicate that in vertebrates, stromal interaction molecule proteins STIM1 and STIM2 are expressed ubiquitously throughout cell types.