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Signal transducing adaptor family member 2

Signal-transducing adaptor protein-2, STAP-2
This gene encodes the substrate of breast tumor kinase, an Src-type non-receptor tyrosine kinase. The encoded protein possesses domains and several tyrosine phosphorylation sites characteristic of adaptor proteins that mediate the interactions linking proteins involved in signal transduction pathways. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Hgb, Src, STAT3, STAT5, MyD88
Papers on Signal-transducing adaptor protein-2
CCR7 is involved in BCR-ABL/STAP-2-mediated cell growth in hematopoietic Ba/F3 cells.
New
Matsuda et al., Sapporo, Japan. In Biochem Biophys Res Commun, Sep 2015
We previously reported that in murine hematopoietic Ba/F3 cells, signal transducing adaptor protein-2 (STAP-2) binds to BCR-ABL and up-regulates BCR-ABL phosphorylation, leading to enhanced activation of its downstream signaling molecules.
STAP-2 Protein Expression in B16F10 Melanoma Cells Positively Regulates Protein Levels of Tyrosinase, Which Determines Organs to Infiltrate in the Body.
New
Matsuda et al., Sapporo, Japan. In J Biol Chem, Aug 2015
In this report, we show that signal transducing adaptor protein 2 (STAP-2) is involved in cell migration, proliferation, and melanogenesis as well as chemokine receptor expression and tumorigenesis in B16F10 melanoma cells.
Signal-transducing adaptor protein-2 regulates macrophage migration into inflammatory sites during dextran sodium sulfate induced colitis.
Kanakura et al., Ōsaka, Japan. In Eur J Immunol, 2014
Signal-transducing adaptor protein-2 (STAP-2) was cloned as a c-fms/M-CSF receptor interacting protein.
Signal-transducing adaptor protein-2 controls the IgE-mediated, mast cell-mediated anaphylactic responses.
Matsuda et al., Sapporo, Japan. In J Immunol, 2014
Signal-transducing adaptor protein-2 (STAP-2) is a recently identified adaptor protein that regulates immune and inflammatory responses through interactions with a variety of signaling and transcriptional molecules.
Adaptor protein STAP-2 modulates cellular signaling in immune systems.
Review
Sekine, In Biol Pharm Bull, 2013
Signal-transducing adaptor protein-2 (STAP-2) is a recently identified adaptor protein that contains a pleckstrin homology (PH), Src homology 2 (SH2)-like domains, and proline-rich regions in its C-terminal.
Estrogen-related genome-based expression profiling study of uterosacral ligaments in women with pelvic organ prolapse.
Kim et al., Seoul, South Korea. In Int Urogynecol J, 2013
We found that estrogen receptor-related receptor-α (ERRα) was downregulated and that the expression of death-associated protein kinase 2 (DAPK 2), signal-transducing adaptor protein-2 (STAP-2), and interleukin (IL)-15 were upregulated.
STAP-2 interacts with and modulates BCR-ABL-mediated tumorigenesis.
Matsuda et al., Sapporo, Japan. In Oncogene, 2012
In this report, we show that the signal-transducing adaptor protein-2 (STAP-2) is involved in BCR-ABL activity.
Signal-transducing adaptor protein-2 modulates Fas-mediated T cell apoptosis by interacting with caspase-8.
GeneRIF
Matsuda et al., Sapporo, Japan. In J Immunol, 2012
STAP-2 is a novel participant in the regulation of T cell apoptosis after stimulation
Involvement of STAP-2 in Brk-mediated phosphorylation and activation of STAT5 in breast cancer cells.
Matsuda et al., Sapporo, Japan. In Cancer Sci, 2011
In a previous study, we found that STAP-2 upregulated Brk-mediated activation of signal transducer and activator of transcription (STAT) 3 in breast cancer cells.
Interactions of STAP-2 with Brk and STAT3 participate in cell growth of human breast cancer cells.
GeneRIF
Matsuda et al., Sapporo, Japan. In J Biol Chem, 2011
Interactions of STAP-2 with Brk and STAT3 participate in cell growth of human breast cancer cells.
Epigenetic modification of retinoic acid-treated human embryonic stem cells.
Shin et al., Seoul, South Korea. In Bmb Rep, 2010
Combined analysis of methylation and expression data revealed that 19 genes (STAP2, VAMP8, C10orf26, WFIKKN1, ELF3, C1QTNF6, C10orf10, MRGPRF, ARSE, LSAMP, CENTD3, LDB2, POU5F1, GSPT2, THY1, ZNF574, MSX1, SCMH1, and RARB) were highly correlated with each other.
[Novel adaptor protein, STAP-2 functions as a signal modulator in immune system].
Review
GeneRIF
Sekine, Japan. In Yakugaku Zasshi, 2010
has a crucial role in immune systems by controlling cytokine signal transduction.
Signal-transducing adaptor protein-2 regulates stromal cell-derived factor-1 alpha-induced chemotaxis in T cells.
GeneRIF
Matsuda et al., Sapporo, Japan. In J Immunol, 2010
STAP-2 expression in Jurkat T cells affects migration following stromal cell-derived factor-1alpha (SDF-1alpha) treatment; STAP-2 association with Vav1, the guanine-nucleotide exchanging factor for Rac1, enhances downstream Vav1/Rac1 signaling.
The protein content of an adaptor protein, STAP-2 is controlled by E3 ubiquitin ligase Cbl.
GeneRIF
Matsuda et al., Sapporo, Japan. In Biochem Biophys Res Commun, 2009
These results indicate that Cbl regulates STAP-2 protein levels and Brk/STAP-2-mediated STAT3 activation.
STAP-2 is phosphorylated at tyrosine-250 by Brk and modulates Brk-mediated STAT3 activation.
GeneRIF
Matsuda et al., Sapporo, Japan. In Biochem Biophys Res Commun, 2009
STAP-2 is phosphorylated at Tyr250 by Brk, and plays an important role in Brk-mediated STAT3 activation.
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